The estimated ACME of rs11031684 through CPD and max CPD were −0.525 (P = 0.04) and −0.619 (P = 0.07), respectively, suggesting that some of the effects of rs11031684 is mediated through CPD. Additionally, we found that rs11031684 was nominally associated with CPD (P = 0.0084) and max CPD (P = 0.0062). The estimated ACME of rs2304808 through CPD and max CPD were 0.231 (P = 0.22) and 0.304 (P = 0.24), respectively, suggesting that the effect of rs2304808 is not mediated through CPD or max CPD.
