The variance explained by all independently associated SNPs in CADM2 taken together ranged from 0.07% for regular alcohol use to 3.02% for regular cannabis use (M = 1.05%, SD = 1.09%, Mdn = 0.45%). The sample sizes included in the analyses ranged from 2,094 to 362,018 individuals (see Table 2). It does not seem to be the case that phenotypes from a particular sample or specific category have higher R 2 than the others. Also, there does not seem to be an effect of the number of SNPs in the analysis on the size of R 2 (r = −0.27, p > 0.05).
