variant in the 6q21 region, which were identified at suggestive levels of significance in a previous study (6). We also note that SNPs at the RAD51L1 locus reported as genome-wide significant for association with ‘number of teeth’ in Pillas et al. (6) did not meet the 5 × 10−8 threshold in this study, although there was still suggestive evidence for association at this locus [‘Age at first tooth’ (rs17105278): P = 2.1 × 10−6; ‘Number of teeth’(rs1956529): P = 6.4 × 10−7]. Table 1.Fifteen loci identified at genome-wide significance in meta-analysis of ‘age at first tooth’ or ‘number of teeth’ in ALSPAC and NFBC1966MarkerGene region/locusChromosomeBase positionA1/A2Effect ALSPACSE ALSPAC% var alspacP-value ALSPACEffect NFBCSE NFBC% var nfbcP-value NFBCEffect metaSE metaP-value metaAge at first tooth rs109326882q352217 571 726G/C−0.1070.0480.052.7 × 10−2−0.1060.0370.134.0 × 10−3−0.1060.0292.9 × 10−4 rs65684016q216106 295 511C/T−0.2280.0490.333.1 × 10−6−0.1680.0370.377.1 × 10−6−0.1900.0301.5 × 10−10 rs1799922CALU/OPN1SW7128 202 431T/G−0.1480.0440.167.8 × 10−4−0.1350.0370.233.2 × 10−4−0.1400.0298.8 × 10−7 rs10740993CACNB21018 482 488C/T−0.1750.0430.244.7 × 10−5−0.1180.0350.196.7 × 10−4−0.1410.02711.9 × 10−7 rs7924176ADK VCL AP3M11075 965 795A/G−0.2610.0430.581.2 × 10−9−0.0810.0370.062.5 × 10−2−0.1670.0281.8 × 10−8 rs4937076CDON11125 331 912A/G−0.1860.0430.271.8 × 10−5−0.1270.0350.213.3 × 10−4−0.1500.0274.0 × 10−8 rs12229918MSRB31264 048 325C/G−0.2730.0440.607.3 × 10−10−0.1760.0390.375.3 × 10−6−0.2180.0297.3 × 10−14 rs17101923HMGA21264 624 469G/T−0.2820.0530.449.99 × 10−8−0.1700.0410.303.5 × 10−5−0.2120.0336.3 × 10−11 rs9316505DLEU71350 288 599A/G−0.1220.0430.104.8 ×
