We identified 10 loci reaching genome-wide significance (P < 5 × 10−8) for ‘age at first tooth’ and a further 11 loci for ‘number of teeth’, giving a total of 15 independent loci (Fig. 1). The full GWAS results corresponding to Figure 1 are available from the Human Molecular Genetics website. Table 1 shows the top-ranking SNPs for each phenotype at each locus. Eight of these loci are novel associations; the top SNPs at these loci are rs17563 (BMP4), rs10740993 (CACNB2), rs4937076 (CDON), rs1799922 (CALU/OPN1SW), rs997154 (AJUBA/C14orf93), rs7924176 (ADK), rs412000 (TEX14/RAD51C) and rs9316505 (DLEU7). Four of the loci identified confirm previously reported genes/regions (6) (KCNJ2, MSRB3, IGF2BP1 and EDA). Furthermore, we detected genome-wide significance for the variant rs17101923 in the HMGA2 region (‘number of teeth’ P = 1.1 × 10−10, Table 1), rs10932688 in the 2q35 region and the rs6568401 variant in the 6q21 region, which were identified at suggestive levels of significance in a previous study (6). We also note that SNPs at the RAD51L1 locus reported as genome-wide significant for association with ‘number of teeth’ in Pillas et
