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Chunk #4 — Results — ACC Lesions Impair the Ability to Inhibit and Redirect Behavior.

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Anterior cingulate cortex is necessary for adaptation of action plans.
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In addition to lesioned rats performing worse on STOP-change trials, they were also slower on STOP-change trials compared to GO trials. Fig. 1D plots the difference between movement times on STOP-change and GO trials and its relationship with the percentage of correct responses over sessions. Distributions for percent correct (t(719) = −2.9087, P = 0.0037) and movement times (t(719) = −2.877, P = 0.0041) were more strongly shifted after lesions when compared to controls, demonstrating that lesioned rats were worse on STOP-change trials compared to GO trials and took longer to alter action plans on STOP-change trials across sessions. Furthermore, there was a significant correlation between the movement time and percent correct indices for both groups (control: r = −0.3069, P < 0.05; lesion: r = −0.175, P < 0.05) indicating that, in sessions where rats performed poorly, they took longer to adapt their action plan.