ASSET identified 5 substance-specific loci for CUD (Supplemental Table 13 and 14), with lead signals at rs11913634 (FAM19A5; p=1.20e-15), rs8104317 (CACNA1A; p=1.17e-13), rs72818514 (ATP10B; p=1.57e-09), and rs11715758 (GNAI2/HYAL3; p=4.84e-08; Supplemental Figure 3D) and rs11778040 (p=1.77e-09; annotated to the GULOP pseudogene). rs11778040 mapped to the previously discovered signal for CUD near CHRNA2 and EPHX215 and is an eQTL for CHRNA2, EPHX2, and CCDC25. CUD-specific signals showed no significant gene-based enrichment.
