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Chunk #22 — Results — Phenotypic analyses — Biometric model fitting

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Most of the genetic covariation between major depressive and alcohol use disorders is explained by trait measures of negative emotionality and behavioral control.
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Results from the bivariate biometric models are displayed in Table 3. These models fit very well (root mean square error of approximation <0.02). Notably, additive genetic factors explained nearly all of the covariation between CON and AUD (0.96) and a substantial proportion of the covariation between CON and MDD (0.83). Genetic contributions to the covariation between SR and the two disorders were less substantial (AUD: proportion A = 0.56, MDD: proportion A = 0.59). Genetic and environmental correlations were also estimated between the psychiatric and personality measures. Whereas SR demonstrated genetic and environmental overlap with psychiatric outcomes, CON demonstrated only genetic overlap.