Chunk #42 — ONLINE METHODS — Statistical analysis

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Large-scale genotyping identifies 41 new loci associated with breast cancer risk.

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λ1,000=1+500(λ-1)∑k(1nk+1mk)-1 where nk and mk are the number of cases and controls, respectively, for study k. Heterogeneity in the per-allele OR by ER status, age at diagnosis, family history and tumor invasiveness (DCIS versus invasive) were evaluated using a case-only analysis.