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Chunk #21 — RESULTS — STUDY 1 — Subjective Anxiety and Alcohol Craving Responses

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Effects of adrenal sensitivity, stress- and cue-induced craving, and anxiety on subsequent alcohol relapse and treatment outcomes.
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As expected, stress and alcohol cue exposure significantly increased both subjective anxiety (condition: F1,140=100.19; P<.001) and alcohol craving (condition: F1,140=53.56; P<.001) relative to the neutral, relaxing condition. Alcohol-dependent patients showed higher anxiety (group: F1,70=7.53; P=.008) and alcohol craving (group: F1,70=9.96; P=.002) relative to controls. A significant group × condition interaction for anxiety (F2,140=24.17; P<.001) indicated that greater anxiety was seen in the alcohol-dependent group vs the control group for the alcohol cue (P<.001) and the neutral, relaxing condition (P<.03), but similar anxiety increases were observed with stress exposure for both groups (P<.18). Also, anxiety increased immediately following imagery and then decreased postimagery over the recovery times (time: F6,490=43.86; P<.001) and this effect was more pronounced in the stress and cue conditions relative to the neutral, relaxing condition (condition × time: F14,975=18.3; P<.001). For alcohol craving, a significant group × condition interaction (F2,140=26.78; P<.001) indicated significantly higher alcohol craving in the alcohol-dependent group vs the control group for the stress (P<.001) and alcohol cue condition (P<.001), but no differences between groups and minimal craving were observed in the neutral condition. Alcohol