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Chunk #1 — METHODS AND MATERIALS — Subjects and Diagnostic Procedures

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Genome-wide association study of nicotine dependence in American populations: identification of novel risk loci in both African-Americans and European-Americans.
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domains assessed by this instrument are how soon the subject smokes his first cigarette after awakening; whether the subject finds it difficult to refrain from smoking in places where it is forbidden; which cigarette the subject would least like to give up (e.g., the first cigarette in the morning); how many cigarettes the subject smokes per day; and whether the subject smokes even if ill enough to be confined to his bed [paraphrased from reference (7)].