Several of the top associations in the combined trio-case-control meta-analysis are in or near genes that have been implicated in other studies of psychiatric disorders, including ADCY859, 71, 72, ARHGAP1847 and JMJD2C 62 in bipolar disorder, schizophrenia and autism spectrum disorders, respectively. Enrichment for eQTLs was observed among the top associated GWAS SNPs (N=5,321; p<0.01), with empirical p-values of 0.001 for frontal cortex, 0.003 for parietal tissue and 0.033 for cerebellum. Marked enrichment was also observed for methylation QTLs (p<0.001). This is consistent with the finding by Nicolae et al. (2010),54 who reported that disease-associated SNPs from GWAS were significantly more likely to be eQTL, than other random sets of SNPs with similar minor-allele-frequencies (MAF).
