It remains unclear whether the finding at rs6131295, which exceeded genome-wide significance with p=3.84×10-8 in the trio sample, is a false positive or not. Certainly the decrease in significance of the p-value to 3.62×10-5 when the trio data is meta-analyzed with the much larger case-control sample data suggests so. On the other hand, our attempts to determine whether this finding was spurious did not find any evidence of such, as detailed here: 1) The intensity plot for this SNP has three tight, separated, clusters (Figure S10a); 2) There were no missing genotypes in the trio sample and there were no Mendelian errors; 3) Two nearby directly genotyped SNPs with low r2 values (0.2-0.4) had p-values within the 10-2 range, demonstrating very low statistical significance (Figure S10b); and 4) Imputation of the trio sample provided additional results that are not inconsistent with a true positive finding. Of the 40 regional SNPs examined, those with large r2 values (>0.90) and similar minor allele frequencies to rs6131295 had strong p-values in the range of 10-6 and 10-7 (Table S7 and Figure S11). Moreover,
