with a true positive finding. Of the 40 regional SNPs examined, those with large r2 values (>0.90) and similar minor allele frequencies to rs6131295 had strong p-values in the range of 10-6 and 10-7 (Table S7 and Figure S11). Moreover, the surrounding SNPs in low r2 with rs6131295 all have an opposite direction of risk effect, which may partially explain why they have much less significant p-values. Although these imputed data and the above noted facts cannot prove that rs6131295 is a true positive, they do not support the hypothesis that it is a false positive. Replication with additional samples will be required to provide further clarification.
