In summary, although no SNPs were identified to be associated with OCD at a genome-wide significant level in the combined trio-case-control sample, a highly significant enrichment of methylation-QTLs (p<0.001) and frontal lobe eQTLs (p=0.001) was observed within the top-ranked SNPs (p<0.01). This suggests that these top signals may have a broad role in gene expression in the brain, and possibly in the etiology of OCD. In the trio sample, we observed a genome-wide significant result for rs6131295, which is located near BTBD3, and is an eQTL for BTBD3, DHRS11 and ISM1. The expression of these latter two genes are highly correlated with other top hits, many of which are related to glutamatergic neurotransmission and signaling. So, while no genome-wide significant associations were found in the entire sample, the convergence of results from both the trio and combined trio-case-control analyses suggest the possibility that our findings at BTBD3, FAIM2 and ADCY8 are genes involved in the pathogenesis of OCD. In the case-control sample, the two most significant p-values were located within DLGAP1, a member of the same gene family as DLGAP3,
