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Chunk #30 — Discussion

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Genome-wide association study of obsessive-compulsive disorder.
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the possibility that our findings at BTBD3, FAIM2 and ADCY8 are genes involved in the pathogenesis of OCD. In the case-control sample, the two most significant p-values were located within DLGAP1, a member of the same gene family as DLGAP3, which is also expressed in the neuronal postsynaptic density complex and which has been implicated in a mouse model of OCD,33 making these results intriguing. Future exploration and attempts to replicate these findings with additional independent samples is warranted.