The correlation of genetic and environmental factors with human disease is vital to the development of diagnostic and therapeutic techniques. Large-scale genotype studies that provide the data for such analysis run the gamut from genome-wide association surveys, medical sequencing, molecular diagnostic assays and surveys of association between genotype and nonclinical traits. Within Entrez, dbGaP (35) (www.ncbi.nlm.nih.gov/gap/) archives, distributes and supports submission of data that correlate genomic characteristics with observable traits. This database is an approved NIH repository for NIH-funded genome-wide association study results (grants.nih.gov/grants/gwas/index.htm). The dbGaP collection has grown rapidly in the past year, from ∼25 studies to now >160, each of which can be browsed by name or disease.
