In the MAGMA gene-based analysis of the EUR data, three genes were significant after multiple testing corrections: CHRNA5, CHRNA3, and IREB2 (Supplemental Table 4). The following three gene sets were significantly associated: “GOBP_TRANSCRIPTION_BY_RNA_POLYMERASE_III,” “GOMF_PRE_MRNA_5_SPLICE_SITE_BINDING,” and “REACTOME_HIGHLY_CALCIUM_PERMEABLE_NICOTINIC_ACETYLCHOLINE_RECEPTORS.” None of the 30 tissue types from GTEx v8 were significant.
