In the EUR data, DSM-NicDep was strongly correlated with the other measures of nicotine dependence (r gs with FTND and ICD-TUD ranged from 0.81 to 1.01). The genetic correlations between DSM-NicDep and published GWASs of substance use disorders were of moderate-to-high magnitude: CanUD, PAU, and OUD (r g = 0.64–0.84). Overall, DSM-NicDep was significantly correlated with 23 of the 26 phenotypes tested (Figure 1 and Supplemental Table 5). Compared to the other tobacco-related phenotypes, DSM-NicDep showed the strongest correlations with many traits, albeit with wider confidence intervals (CIs) due to smaller sample sizes. When correcting for 24 comparisons, the genetic correlations between DSM-NicDep and SmkInit, cannabis ever-use, CanUD, PAU, and the Townsend Deprivation Index were significantly larger (p < 0.002) than the corresponding genetic correlations between FTND and these phenotypes.
