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Chunk #12 — Results

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High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at Risk.
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By the end of the follow-up period, 1544 of 2794 subjects were unaffected, and 606 were diagnosed with mild AUD, 365 with moderate AUD, and 279 with severe AUD. In total, 45% of subjects were diagnosed with AUD during the assessment period [for additional detail on outcomes, see (38)]. Table 1 shows the distribution of subjects in various clinical categories.Table 1Description of the Sample by Clinical/Demographic VariablesVariableEuropean Ancestry, n = 559 FamiliesAfrican Ancestry, n = 218 FamiliesTotalnColumn%aRow%bnColumn%aRow%bn (%)Sex Female95350.91%66.74%47551.52%33.26%1428 (51.11%) Male91949.09%67.28%44748.48%32.72%1366 (48.89%) Total1872100.00%67.00%922100.00%33.00%2794 (100.00%)Comorbidity Internalizing only894.75%80.18%222.39%19.82%111 (3.97%) Externalizing only50827.14%59.42%34737.64%40.58%855 (30.60%) Both1709.08%66.93%849.11%33.07%254 (9.09%) Neither110559.03%70.20%46950.87%29.80%1574 (56.34%) Total1872100.00%67.00%922100.00%33.00%2794 (100.00%)Peer Drinking Peer drinking85845.83%70.04%36739.80%29.96%1225 (43.84%) No peer drinking101254.06%64.58%55560.20%35.42%1567 (56.08%) Not available20.11%100.00%00.00%0.00%2 (0.07%) Total1872100.00%67.00%922100.00%33.00%2794 (100.00%)Case/Comparison Status Subjects from case families155983.28%64.24%86894.14%35.76%2427 (86.86%) Subjects from comparison families31316.72%85.29%545.86%14.71%367 (13.14%) Total1872100.00%67.00%922100.00%33.00%2794 (100.00%)Age of First Drink Has onset age of first drink167489.42%67.61%80286.98%32.39%2476 (88.62%) No first drink reported19810.58%62.26%12013.02%37.74%318 (11.38%) Total1872100.00%67.00%922100.00%33.00%2794 (100.00%)AUD Diagnosis Mild42322.60%69.80%18319.85%30.20%606 (21.69%) Moderate27914.90%76.44%869.33%23.56%365 (13.06%) Severe22311.91%79.93%566.07%20.07%279 (9.99%) No AUD94750.59%61.33%59764.75%38.67%1544 (55.26%) Total1872100.00%67.00%922100.00%33.00%2794 (100.00%)AUD, alcohol use disorder.aColumn% = % of total in that column.bRow% = % of total in that row.