Chunk #11 — Methods and Materials — Construction of PRSs

Source

High Polygenic Risk Scores Are Associated With Early Age of Onset of Alcohol Use Disorder in Adolescents and Young Adults at Risk.

Embedded

yes

Text

Time-dependent ROC curves were created to examine predictive value for the diagnosis of any AUD or severe AUD at a given age (and an integrated value for the age range 15–27). Area under the curve (AUC) was calculated to assess the performance of the model. All statistical analyses (except calculation of PRS) were run using SAS/STAT 15.1 (51).