Kaplan-Meier curves were used to estimate the survival function of AOO of AUD. A Cox proportional hazards model was used to test the relationship of AOO with PRSs adjusted for sex, relatedness, and case/comparison family status in the original model. Other variables added into the model for specific analyses included comorbid disorders, age of first drink, and peer drinking. The proportional hazards assumption was tested in these analyses and was not violated.
