the clinical symptoms of AD (Snowdon et al., 1997). Aβ accumulation and other AD changes are also recognized in elderly patients without apparent dementia (Funato et al., 1998; Schneider et al., 2007), which implies a strong relationship between AD neuropathology and the aging processes. Many reports have described that a majority of sporadic dementia patients have a mixture of AD and CVD pathology (Neuropathology Group of Medical Research Council Cognitive Function and Aging Study (MRC CFAS), 2001; Toledo et al., 2013). Hemorrhage, infarctions, and vascular changes are not specific indicators for VaD.
