The APPRIS web site allows the user to search genes and transcripts and displays six panels of annotations. The first panel shows all the GENCODE/Ensembl-coding variants and highlights the main functional variant. The second panel shows the APPRIS annotations in detail and includes information such as the number of functional residues detected by firestar, the Matador3D homologous structure score or the number of vertebrate species that align in CORSAIR. The next two panels map the APPRIS annotations onto the amino acid sequences of all coding variants and make the annotations visible in the genome regions provided by the UCSC Genome Browser (39). Finally, there are panels that allow the user to compare and contrast proteomic (37,40) and RNAseq (4) evidence tracks against the APPRIS annotation tracks in the UCSC Browser (see Supplementary Data for more details).
