APPRIS has been designed to be portable, modular and flexible and it can be accessed as web services. These services can retrieve the results of the execution of APPRIS methods and other useful information for genes/transcripts. Plain text, JSON/GTF format or BED format (which facilitates the visualization of annotation tracks across genomic regions) outputs are available. In addition, APPRIS supports the downloading of data through the highly customizable BioMart (41) data mining tool.