guidelines that were followed carefully and consistently for all patients (Figure 2). Same as the previous studies (Brandstack, Kurki, Laalo, Kauko, & Tenovuo, 2016; Huang et al., 2005; Lebel et al., 2010), fibers that were clearly not part of the anatomical connectivity of the tracking were manually removed with exclusion ROIs to include only fibers within the desired tract. Calculation of FA was made by averaging all voxels for each region over the entire tracking. Tractography was performed by one operator (Y.O.). In order to assess validity of ROI procedure, another operator (K.T.) who was blinded subjects' diagnosis, age, gender, and handedness analyzed five subjects in the SZ group and five subjects in the HC group, and interoperator reliabilities for FA values were examined. Intraclass correlation coefficients of FA value of seven segments (orbital frontal, anterior frontal, superior frontal, superior parietal, posterior parietal, temporal, and occipital) were 0.903, 0.956, 0.976, 0.976, 0.726, 0.953, and 0.740, respectively.
