neuroticism44 and depression46. The phenome-wide scan of rs9291211 in the UK Biobank showed an effect of this SNP on a wide range of complex traits, some with an easy-to-conceptualize relationship to OD such as alcohol consumption, neuroticism, depression, and anxious feelings. Considering traits related to mental and behavioral disorders attributable to use of alcohol, cannabis, and tobacco, we observed that rs9291211 is associated with alcohol consumption and tobacco smoking and not with dependence-relevant phenotypes. This support that this variant may have pleiotropic effects across consumption of multiple substancs. In our phenome-wide analysis, the strongest results were observed with respect to dietary habits: rs9291211*A was positively associated with reduced OE risk in the PGC-SUD cohorts and with increased propensity to use dietary supplements, such as vitamin and mineral supplements in the UK Biobank. A recent GWAS identified several loci associated with dietary habits and indicated a causal relationship between educational attainment and healthy eating47. With respect to rs9291211, we also observed a nominally significant association with traits related to educational attainment (e.g., UK Biobank Field ID: 6138 Qualification [College or University degree], p=0.033). Accordingly, we hypothesize that rs9291211 could be involved in the individual variability to consume chemicals ranging from dietary
