In the discovery GWAS, 59 SNPs (41 in AAs, 16 in EAs, and 2 in the meta-analysis) surpassed the suggestive threshold (p < 5.0 × 10−6) and were tested in the replication phase (Table S1). Results for the GWS SLC25A16 SNP in the replication sample were unavailable due to a very small minor allele count. The finding with the GNAO1 SNP that was nearly GWS in the discovery sample was replicated (p = 0.0065) and nearly GWS in the combined sample (p = 1.09 × 10−7, OR = 2.66, Table 2). In contrast, the association with the LRP1B-KYNU SNP that was GWS in the discovery sample was not confirmed in the replication sample but was still highly significant in the combined sample (p = 3.13 × 10−7). The associations with the KCNA4 and CPLV SNPs were slightly more significant when combined with the replication datasets (p = 2.99 × 10−7 and p = 3.05 × 10−7, respectively), noting that the CPVL SNP was significant in the AA replication sample (p = 0.0024) and the effect direction was the same across
