Next, we considered the replication attempts in East Asian populations. Out of 225 replication attempts, 103 were successful at a P<0.05 threshold (45.8%). This replicability departs significantly from the null expectation (103 vs. 11.3 expected, P<10−16) and is robust across replication thresholds (e.g. 49 observed vs. 0.23 expected for P<0.001 and 19 observed vs. 2.3×10−5 expected for P<10−7). Nevertheless, that figure is smaller than for Europeans, which can be expected since East Asian GWAS tend to have smaller sample sizes and, thus, less power [15]. We tested this hypothesis by calculating replicability rates after controlling for statistical power. First, we focused on the 81 attempts with ≥80% power to replicate the Odds Ratio (OR) found in Europeans (Table S5 and Materials and Methods). For that subset, replicability increases dramatically to 76.5% (62 out of 81 attempts are successful with a P<0.05 threshold). Second, we calculated that at most 132 positive replications would be expected out of statistical power (59% on average for the 225 attempts in East Asians, Table S5). The 103 observed replications thus correspond to an effective replicability
