Baseline data were gathered using a variation of the Renard Diagnostic Interview, and at follow-up using questions from the Semi-Structured Assessment for the Genetics of Alcoholism interview (SSAGA) (Hesselbrock et al., 1999; Robins et al., 1981). The latter has one-week retest reliabilities for SUDs and AUDs of ~.75 (Hesselbrock et al., 1999). Follow-up information was gathered from subjects and resource persons (spouses or first-degree relatives) who gave information using an interview similar to the probands’, with the higher figure for an item from either informant used if the two sources disagreed. Follow-up data included the prior five-year interval use of alcohol, illicit drugs and cigarettes, as well as personal and FHs of DSM-IV substance-related and independent major depressive and anxiety disorders (American Psychiatric Association, 1994). The Family History Assessment Module (FHAM) was used to gather information regarding lifetime AUDs and SUDs in the proband's biological parents (Rice et al., 1995).
