slices an induction protocol that depolarizes DA neurons led to LTP, thus obeying a Hebbien induction rule, this protocol was inefficient after cocaine treatment. Conversely a slight hyperpolarization of the DA neurons during afferent stimulation (i.e. “anti-Hebbian” coincidence) induced a strengthening of AMPAR-transmission only in slices from mice that had received cocaine. Thus, cocaine administration not only causes a lasting change in the basal properties of excitatory synapses but may also inverses of the rules of activity-dependent synaptic plasticity.
