Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling.

paper Cited Public

Authors: Lüscher, Christian; Malenka, Robert C
Year: 2011
Journal: Neuron
PMID: 21338877
DOI: 10.1016/j.neuron.2011.01.017
PMCID: PMC4046255

Figure 1

The mesocorticolimbic dopamine system as target of addictive drugsOn a saggital slice, the vental tegmental area (VTA), the nucleus accumbens (NAc) and the prefrontal cortex (PFC) can be visualized. The projection neurons are mostly dopaminergic, and under inhibitory control of local GABA neurons (i.e. interneurons). Enlaged schematics to illustrate three cellular mechanims, by which addictive drugs increase mesolimbic DA levels. Nicotine can directly depolarize DA neurons, while opioids, GHB, benzodiazepines and cannabinoids act indirectly via pre- and postsynaptic inhibition of interneurons (i.e. disinhibition). Cocaine, amphetamines and ecstasy target the dopamine transporter (DAT) on axon terminals as well as on dendrites of DA neurons. While cocaine act as an inhibitor of the DAT, promote amphetamines and ecstasy non-vesicular release. In both cases DA levels in the VTA, NAc and PFC increase.

Figure 2

Drug-evoked synaptic plasticity in excitatory synapses onto VTA DA neuronsThe schematics are drawn from a postembedding EM micrograph of a drug-naive mouse (courtesy Rafael Lujan, Albacete). Note that these asymetrical synapses are made directly onto the shaft of the dendrite (aspiny shaft synapse). In naïve animals NMDARs and AMPARs are present, the latter all containing GluA2. After one dose of cocaine, some GluA2 containing AMPARs are exchanged for GluA2 lacking ones through mechanisms involving endo- and exocytosis. After a week of a passive injection (months after self-administration) the baseline composition is restored through mGluR1 activation, mTOR signaling and de novo synthesis of GluA2 from prefabricated mRNA. Throughout the whole process the total number of receptors remains constant.

Figure 3

Drug-evoked synaptic plasticity in excitatory synapses onto medium spiny neurons in the NAcThe schematics are drawn from postembedding EM micrograph of a drug-naive mouse (courtesy Rafael Lujan, Albacete). Note that these neurons have prominent spines. In naive animals NMDARs and GluA2-containing AMPARs are present. After several dose of cocaine (or a challenge dose that terminates withdrawal), some AMPARs are endoytosed and the synapse depressed. After weeks of withdrawal, GluA-lacking AMPARs appear, which lead to a potentation of this synapse.

Figure 4

Emerging model of mesolimbic circuit known to be affected by drug-evoked synaptic plasticityFor simplicity several projections have been omitted to highlight the synapses that undergo drug-evoked adaptations. For further explanation see text. Dopamine neurons (red) GABA neurons (green) and glutamate neurons (blue).

#	Section	Preview
0	From acute drug effects to persistent synaptic adaptations	Addictive drugs mediate their reinforcing properties by targeting the mesocorticolimbic dopamine…
1	From acute drug effects to persistent synaptic adaptations	al., 2004) and benzodiazepines (Tan et al., 2010) primarily target GABAergic interneurons in the VTA…
2	From acute drug effects to persistent synaptic adaptations	as in the NAc and PFC. Important mechanistic differences exist between the individual members of…
3	From acute drug effects to persistent synaptic adaptations	These initial actions of addictive drugs have been extensively studied and remain important targets…
4	From acute drug effects to persistent synaptic adaptations	plasticity, the neural circuit adaptations that underlie drug-induced behavioral changes will…
5	From acute drug effects to persistent synaptic adaptations	Focusing on the mesocorticolimbic DA system makes sense not only because it is well established to…
6	From acute drug effects to persistent synaptic adaptations	point to important avenues of future research. We will also exhibit the strong bias that changes in…
7	Molecular mechanisms of drug-evoked plasticity — VTA — Excitatory transmission	In the 90’s, based primarily on pharmacological manipulations and biochemical assays as well as…
8	Molecular mechanisms of drug-evoked plasticity — VTA — Excitatory transmission	measure of synaptic strength, the authors measured the ratio of the AMPA receptor-mediated ESPC…
9	Molecular mechanisms of drug-evoked plasticity — VTA — Excitatory transmission	occurs following administration of other addictive drugs, including morphine, nicotine, ethanol, and…
10	Molecular mechanisms of drug-evoked plasticity — VTA — Excitatory transmission	Several results suggest that activation of VTA DA neurons alone is sufficient to elicit this form of…
11	Molecular mechanisms of drug-evoked plasticity — VTA — Excitatory transmission	to cocaine (Brown et al., 2010). An additional induction requirement for this drug-evoked synaptic…
12	Molecular mechanisms of drug-evoked plasticity — VTA — Excitatory transmission	The expression mechanisms of the drug-evoked plasticity at excitatory synapses on VTA DA neurons…
13	Molecular mechanisms of drug-evoked plasticity — VTA — Excitatory transmission	microscopy level did show an increase of GluA1 after morphine treatment (Lane et al., 2008) and that…
14	Molecular mechanisms of drug-evoked plasticity — VTA — Excitatory transmission	slices an induction protocol that depolarizes DA neurons led to LTP, thus obeying a Hebbien…
15	Molecular mechanisms of drug-evoked plasticity — VTA — Excitatory transmission	As mentioned above drug-evoked synaptic plasticity at this synapse persists for about a week after a…
16	Molecular mechanisms of drug-evoked plasticity — VTA — Excitatory transmission	in the VTA significantly prolongs the persistence of cocaine-evoked plasticity (Mameli et al.,…
17	Molecular mechanisms of drug-evoked plasticity — VTA — Excitatory transmission	Although the drug-evoked synaptic plasticity in VTA DA neurons is robust, recent studies have…
18	Molecular mechanisms of drug-evoked plasticity — VTA — Excitatory transmission	aversive stimulus (Lammel and Malenka, 2010). The exclusively DAergic nature of VTA projection…
19	Molecular mechanisms of drug-evoked plasticity — VTA — Excitatory transmission	An additional important question is whether the drug-evoked synaptic plasticity in VTA DA neurons is…

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In this knowledge base

Title	Year	PMID
The genetic epidemiology of substance use disorder: A review.	2017	28938182
Sorting nexin 27 regulation of G protein-gated inwardly rectifying K⁺ channels attenuates in vivo cocaine response.	2014	24811384
ELK1 transcription factor linked to dysregulated striatal mu opioid receptor signaling network and OPRM1 polymorphism in human heroin abusers.	2013	23702428

External

Title	Authors	Journal	Year	Link
A prefrontal cortex-nucleus accumbens circuit attenuates cocaine-conditioned place preference memories.	Wu X et al.	—	2026	→
Change in brain molecular landscapes following electrical stimulation of the nucleus accumbens.	Cai C et al.	—	2026	→
Chronic morphine differentially impacts glutamatergic synaptic plasticity in the ventral tegmental area of adult versus adolescent mice.	Edwards JG et al.	—	2026	→
Disruption of <i>chrna5</i> blunts aversion and adaptive transcriptomic responses to nicotine and alcohol.	Goel T et al.	—	2026	→
Distinct interneuronal dynamics selectively gate target-specific cortical projections in drug seeking.	Jeong M et al.	—	2026	→
Emerging Roles of GluN3B NMDA Receptor Subunit in the Central Nervous System.	Huang Y et al.	—	2026	→
Histone Deacetylase 5 in Prelimbic Prefrontal Cortex Limits Context-Associated Cocaine Seeking.	Barry SM et al.	—	2026	→
Ibogaine: Therapeutic Potential, Cardiac Safety, and Translational Perspectives in the Treatment of Substance Use Disorders-A Scoping Review.	Esperança MP et al.	—	2026	→
Purinergic P2X7 receptor signaling in anxiety: Roles of stress-related neuroinflammatory mechanisms and therapeutic horizons.	Kaur S et al.	—	2026	→
Sleep regulates drug seeking and relapse - a perspective.	Liu YZ et al.	—	2026	→
Transcriptional regulation of ventral hippocampus-nucleus accumbens circuit excitability drives cocaine seeking.	Eagle AL et al.	—	2026	→
Transcription factors implicated in substance use disorder, from immediate early genes to altered gene expression.	Orr E et al.	—	2026	→
Astrocytes Control Cocaine-Induced Synaptic Plasticity and Reward Through the Matricellular Protein Hevin.	Mongrédien R et al.	—	2025	→
Astrocytes Mediate Psychostimulant-Induced Alterations of Spike-Timing Dependent Synaptic Plasticity.	Alberquilla S et al.	—	2025	→
Astrocytic G Protein-Coupled Receptors in Drug Addiction.	Zinsmaier AK et al.	—	2025	→
Astroglial CB<sub>1</sub> Reveal Sex-Specific Synaptic Effects of Amphetamine.	Mariani Y et al.	—	2025	→
Brain-Behavior Relationships: Neural Mechanisms of Impulsivity and Compulsivity in Neuropsychiatric Disorders.	Maerean N et al.	—	2025	→
Cocaine-Induced Remodeling of the Rat Brain Peptidome: Quantitative Mass Spectrometry Reveals Anatomically Specific Patterns of Cocaine-Regulated Peptide Changes.	Lu G et al.	—	2025	→
Comparative effects of arecoline, caffeine, and nicotine on transcription level in the nucleus accumbens of mice.	Huang S et al.	—	2025	→
Complex opioid-driven modulation of glutamatergic and cholinergic neurotransmission in a GABAergic brain nucleus associated with emotion, reward, and addiction.	Chittajallu R et al.	—	2025	→
Connectome Analysis of the Nucleus Accumbens: Refining Radiosurgical Targeting for Addictive Disorders.	Chang JE et al.	—	2025	→
Default mode network-basal ganglia network connectivity predicts the transition to postherpetic neuralgia.	Wu Y et al.	—	2025	→
Drug-Related Engrams and Their Role in the Persistence and Recurrence of Drug-Related Behaviors.	Cutler M et al.	—	2025	→
Effects of naltrexone on gabapentin reward and buprenorphine combinations in male mice.	LaCrosse AL et al.	—	2025	→
Emerging Interventions in Behavioral Addictions: A Narrative Review of Psychedelics and Neuromodulation.	Ulisse K et al.	—	2025	→
GABA<sub>B</sub> Receptor: Structure, Biological Functions, and Therapy for Diseases.	Xie W et al.	—	2025	→
Ibogaine's potential role in supporting reward system recovery across diagnostic boundaries.	Nicolas M	—	2025	→
Maladaptation diseases as disorders of intraorganismal individuation.	Lissek T	—	2025	→
Mechanisms of glucagon-like-peptide 1 in the brain beyond metabolic effects.	Kim KS et al.	—	2025	→
Medial prefrontal cortex circuit dynamics involved in stage-specific addiction.	Zhao D et al.	—	2025	→
Monoamine depletion and oxidative imbalance underlie ketamine-induced motor deficits in adolescent rats.	Kobayashi NHC et al.	—	2025	→
Multifunctional Neural Probes Enable Bidirectional Electrical, Optical, and Chemical Recording and Stimulation In Vivo.	Driscoll N et al.	—	2025	→
Neural basis of adolescent THC-induced potentiation of opioid responses later in life.	Hubbard E et al.	—	2025	→
Neural modulation by nicotine aerosols and the role of flavor additives: insights from local field potentials in mice.	Sun J et al.	—	2025	→
Nuclear Calcium Signaling in D<sub>1</sub> Receptor-Expressing Neurons of the Nucleus Accumbens Regulates Molecular, Cellular, and Behavioral Adaptations to Cocaine.	Saint-Jour E et al.	—	2025	→
Nucleus Accumbens: A Therapeutic Target for Radiomodulation for the Treatment of Alcohol Use Disorder.	Amurthur R et al.	—	2025	→
Prescription Opioid Misuse, Comorbid Substance Use, and Suicidal Behaviors Among US Young Adults: Findings from 2015-2019 National Survey on Drug Use and Health.	Oh S et al.	—	2025	→
Psilocybin reduces heroin seeking behavior and modulates inflammatory gene expression in the nucleus accumbens and prefrontal cortex of male rats.	Floris G et al.	—	2025	→
Psychedelics as pharmacotherapeutics for substance use disorders: A scoping review on clinical trials and perspectives on underlying neurobiology.	Wittenkeller L et al.	—	2025	→
Psychedelics Reverse the Polarity of Long-Term Synaptic Plasticity in Cortical-Projecting Claustrum Neurons.	Anderson TL et al.	—	2025	→
Repeated cocaine exposure and prolonged withdrawal induce spatial memory impairment and dysregulate the glutamatergic synapse composition in the dorsal hippocampus of male rats.	Mottarlini F et al.	—	2025	→
Reward-associated cues reduce H-current amplitude in midbrain dopamine neurons.	Calo-Guadalupe CG et al.	—	2025	→
Striatal transcriptomic alterations immediately after short-term abstinence from methamphetamine self-administration in rats.	Jang WJ et al.	—	2025	→
Structural neural plasticity evoked by rapid-acting antidepressant interventions.	Liao C et al.	—	2025	→
Synaptic Plasticity Linked to Ionotropic Glutamate Receptors After Nicotine Exposure.	Kazmi A et al.	—	2025	→
The how and why of sleep: Motor theory and catecholamine hypothesis.	Ma C et al.	—	2025	→
The neurobiology of overeating.	Stuber GD et al.	—	2025	→
The neuroplastic brain: current breakthroughs and emerging frontiers.	Gazerani P	—	2025	→
The Orbitofrontal Cortex to Striatal Cholinergic Interneuron Circuit Controls Cognitive Flexibility Shaping Alcohol-Seeking Behavior.	Li J et al.	—	2025	→
Trans-synaptic modulation of cholinergic circuits tunes opioid reinforcement.	Zucca S et al.	—	2025	→
Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses.	Oriol L et al.	—	2025	→
Voluntary wheel running during adolescence prevents the increase in ethanol intake induced by social defeat in male mice.	Reguilón MD et al.	—	2025	→
When bariatric surgery reduces food addiction: a prospective study.	Ban XY et al.	—	2025	→
3'-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome.	Qi Y et al.	—	2024	→
Activation of nucleus accumbens projections to the ventral tegmental area alters molecular signaling and neurotransmission in the reward system.	Khayat A et al.	—	2024	→
Activation of RMTg projections to the VTA reverse cocaine-induced molecular adaptation in the reward system.	Khayat A et al.	—	2024	→
Acupuncture in the treatment of cocaine addiction: how does it work?	Sun L et al.	—	2024	→
A discrete subpopulation of PFC-LHb neurons govern cocaine place preference.	Abdel-Hay N et al.	—	2024	→
Analysis of the <i>BDNF</i> Gene rs6265 Polymorphism in a Group of Women with Alcohol Use Disorder, Taking into Account Personality Traits.	Boroń A et al.	—	2024	→
Behavioral video coding analysis of chronic morphine administration in rats.	Yin J et al.	—	2024	→
BLA DBS improves anxiety and fear by correcting weakened synaptic transmission from BLA to adBNST and CeL in a mouse model of foot shock.	Gao Y et al.	—	2024	→
Cajal, the neuronal theory and the idea of brain plasticity.	Rozo JA et al.	—	2024	→
Calcium-permeable AMPA and kainate receptors of GABAergic neurons.	Zinchenko VP et al.	—	2024	→
Cellular and circuit architecture of the lateral septum for reward processing.	Chen G et al.	—	2024	→
Complex opioid driven modulation of glutamatergic and cholinergic neurotransmission in a GABAergic brain nucleus associated with emotion, reward and addiction	Chittajallu R et al.	—	2024	—
Conditional deletion of the AMPA-GluA1 and NMDA-GluN1 receptor subunit genes in midbrain D1 neurons does not alter cocaine reward in mice.	Borruto AM et al.	—	2024	→
Cortical plasticity differences in substance use disorders.	Liu QM et al.	—	2024	→
Dopaminergic and Glutamatergic Mechanisms in Addiction: Assessing the Therapeutic Promise of Memantine and Galantamine for Maintenance Treatment: A Review.	Jamali Q et al.	—	2024	→
Elucidating the molecular symphony: unweaving the transcriptional & epigenetic pathways underlying neuroplasticity in opioid dependence and withdrawal.	Wani SN et al.	—	2024	→
Exploring habenular structural connectivity in Parkinson's disease: insights from 7 T MRI study.	Samanci B et al.	—	2024	→
Focused Ultrasound Combined With Microbubbles Attenuate Symptoms in Heroin-Addicted Mice.	Feng Y et al.	—	2024	→
Harnessing the sensing and stimulation function of deep brain-machine interfaces: a new dawn for overcoming substance use disorders.	Chen D et al.	—	2024	→
Learning to become addicted, one synapse at a time.	Attardo A et al.	—	2024	→
Long-term disruption of tissue levels of glutamate and glutamatergic neurotransmission neuromodulators, taurine and kynurenic acid induced by amphetamine.	Taracha E et al.	—	2024	→
<i>Tmod2</i> Is a Regulator of Cocaine Responses through Control of Striatal and Cortical Excitability and Drug-Induced Plasticity.	Mitra A et al.	—	2024	→
Mechanistic and structural studies reveal NRAP-1-dependent coincident activation of NMDARs.	Goodell DJ et al.	—	2024	→
Modulating reward and aversion: Insights into addiction from the paraventricular nucleus.	Huang S et al.	—	2024	→
Modulation of mGlu5 reduces rewarding associative properties of nicotine via changes in mesolimbic plasticity: Relevance to comorbid cigarette smoking in psychosis.	Peeters LD et al.	—	2024	→
Molecular and circuit determinants in the globus pallidus mediating control of cocaine-induced behavioral plasticity.	Tian G et al.	—	2024	→
Morphine-Driven m6A Epitranscriptomic Neuroadaptations in Primary Cortical Cultures.	Dabrowski KR et al.	—	2024	→
Neuromarkers in addiction: definitions, development strategies, and recent advances.	Harp NR et al.	—	2024	→
Opioid drugs drive electrical insulation of reward circuitry.	—	—	2024	→
PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury.	Wagner J et al.	—	2024	→
Representational maps in the brain: concepts, approaches, and applications.	Noda T et al.	—	2024	→
Sex dependence of opioid-mediated responses to subanesthetic ketamine in rats.	Di Ianni T et al.	—	2024	→
Sign-tracking to non-drug reward is related to severity of alcohol-use problems in a sample of individuals seeking treatment.	Watson P et al.	—	2024	→
Synaptic Structure and Transcriptomic Profiling of Reward and Sensory Brain Areas in Male Mice of Fentanyl Addiction.	Feng J et al.	—	2024	→
Targeting mitochondrial dynamics of morphine-responsive dopaminergic neurons ameliorates opiate withdrawal.	Jiang C et al.	—	2024	→
Targeting the cytoskeleton as a therapeutic approach to substance use disorders.	Pandey S et al.	—	2024	→
The ion channel TRPA1 is a modulator of the cocaine reward circuit in the nucleus accumbens.	Kim YJ et al.	—	2024	→
The mutated cytoplasmic fragile X messenger ribonucleoprotein 1 (FMR1)-interacting protein 2 (CYFIP2 S968F) regulates cocaine-induced reward behaviour and plasticity in the nucleus accumbens.	Kim YJ et al.	—	2024	→
The nucleus accumbens in reward and aversion processing: insights and implications.	Xu Y et al.	—	2024	→
Therapeutic mechanisms of psychedelics and entactogens.	Heifets BD et al.	—	2024	→
Abstinence from Escalation of Cocaine Intake Changes the microRNA Landscape in the Cortico-Accumbal Pathway.	Kumaresan V et al.	—	2023	→
Accumbal-thalamic connectivity and associated glutamate alterations in human cocaine craving: A state-dependent rs-fMRI and <sup>1</sup>H-MRS study.	Engeli EJE et al.	—	2023	→
Activation of calcium-sensing receptors in the basolateral nucleus of the amygdala inhibits food intake and induces anxiety-depressive-like emotions via dopamine system.	Guo Y et al.	—	2023	→
Activation of Kv7 channels normalizes hyperactivity of the VTA-NAcLat circuit and attenuates methamphetamine-induced conditioned place preference and sensitization in mice.	Liu E et al.	—	2023	→
Acute adolescent morphine exposure improves dark avoidance memory and enhances long-term potentiation of ventral hippocampal CA1 during adulthood in rats.	Khani F et al.	—	2023	→
Age-dependent effects of tobacco smoke and nicotine on cognition and the brain: A systematic review of the human and animal literature comparing adolescents and adults.	Colyer-Patel K et al.	—	2023	→
Aging in nucleus accumbens and its impact on alcohol use disorders.	Konar-Nié M et al.	—	2023	→
Autophosphorylation of αCaMKII regulates alcohol consumption by controlling sedative effects of alcohol and alcohol-induced loss of excitatory synapses.	Cały A et al.	—	2023	→
Beyond the 5-HT<sub>2A</sub> Receptor: Classic and Nonclassic Targets in Psychedelic Drug Action.	Cameron LP et al.	—	2023	→
Canalization and plasticity in psychopathology.	Carhart-Harris RL et al.	—	2023	→
Chronic Ethanol Exposure Modulates Periaqueductal Gray to Extended Amygdala Dopamine Circuit.	Pati D et al.	—	2023	→
CNTN1 in the Nucleus Accumbens is Involved in Methamphetamine-Induced Conditioned Place Preference in Mice.	Zhang L et al.	—	2023	→
Computational models of behavioral addictions: State of the art and future directions.	Kato A et al.	—	2023	→
Differential Effects of Cocaine and Morphine on the Diurnal Regulation of the Mouse Nucleus Accumbens Proteome.	Ketchesin KD et al.	—	2023	→
Differential Patterns of Synaptic Plasticity in the Nucleus Accumbens Caused by Continuous and Interrupted Morphine Exposure.	Lefevre EM et al.	—	2023	→
Effectiveness of eye movement exercise and diaphragmatic breathing with jogging in reducing migraine symptoms: A preliminary, randomized comparison trial.	Rahimi MD et al.	—	2023	→
Evaluation of the effect of mesenchymal stem cells injection in the nucleus accumbens on the morphine reinstatement behavior in a conditioned place preference model in Wistar rat: Expression changes of NMDA receptor subunits and NT-3.	Dousti Kataj P et al.	—	2023	→
Exploring opportunities for drug repurposing and precision medicine in cannabis use disorder using genetics.	Greco LA et al.	—	2023	→
Functional neuroanatomy of craving in heroin use disorder: voxel-based meta-analysis of functional magnetic resonance imaging (fMRI) drug cue reactivity studies.	Pollard AA et al.	—	2023	→
Intravenous Injection of GluR2-3Y Inhibits Repeated Morphine-Primed Reinstatement of Drug Seeking in Rats.	Zhang J et al.	—	2023	→
Investigating role of ASIC2 in synaptic and behavioral responses to drugs of abuse.	Fuller MJ et al.	—	2023	→
Linking input- and cell-type-specific synaptic plasticity to the reinforcement of alcohol-seeking behavior.	Xie X et al.	—	2023	→
Maladaptive plasticity induced by morphine is mediated by hippocampal astrocytic Connexin-43.	Darvishmolla M et al.	—	2023	→
Mini-review: The neurobiology of treating substance use disorders with classical psychedelics.	Urban MM et al.	—	2023	→
Neural correlates of cocaine-induced conditioned place preference in the posterior cerebellar cortex.	Rodríguez-Borillo O et al.	—	2023	→
Neuropharmacology of Alcohol Addiction with Special Emphasis on Proteomic Approaches for Identification of Novel Therapeutic Targets.	Ray SK et al.	—	2023	→
Normalization of the H3K9me2/H3K14ac-ΔFosB pathway in the nucleus accumbens underlying the reversal of morphine-induced behavioural and synaptic plasticity by Compound 511.	Wang Q et al.	—	2023	→
Obesity-mediated Lipoinflammation Modulates Food Reward Responses.	Huerta-Canseco C et al.	—	2023	→
Opioid-induced fragile-like regulatory T cells contribute to withdrawal.	Zhu Y et al.	—	2023	→
Opposing Spatially Segregated Function of Endogenous GDNF-RET Signaling in Cocaine Addiction.	Garton DR et al.	—	2023	→
Oral oxycodone self-administration leads to features of opioid misuse in male and female mice.	Slivicki RA et al.	—	2023	→
Plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density.	Kroll SL et al.	—	2023	→
Reinstatement of nicotine conditioned place preference in a transgenerational model of drug abuse vulnerability in psychosis: Impact of BDNF on the saliency of drug associations.	Peeters LD et al.	—	2023	→
Role of sex hormones in the effects of sleep deprivation on methamphetamine reward memory.	Shahveisi K et al.	—	2023	→
Shared GABA transmission pathology in dopamine agonist- and antagonist-induced dyskinesia.	Abe Y et al.	—	2023	→
SNAP25 differentially contributes to G<sub>i/o</sub>-coupled receptor function at glutamatergic synapses in the nucleus accumbens.	Manz KM et al.	—	2023	→
Synaptic and cellular endocannabinoid signaling mechanisms regulate stress-induced plasticity of nucleus accumbens somatostatin neurons.	Kondev V et al.	—	2023	→
The activity-regulated cytoskeleton-associated protein, Arc, functions in the nucleus accumbens shell to limit multiple triggers of cocaine-seeking behaviour.	Barry SM et al.	—	2023	→
The administration of Alda-1, an activator of ALDH2, inhibits relapse-like ethanol intake in female alcohol-preferring UChB rats.	Quilaqueo ME et al.	—	2023	→
The blockade of orexin receptors within the dentate gyrus of the hippocampus attenuated methamphetamine-induced reward learning during conditioning place preference.	Modaberi S et al.	—	2023	→
Timing is key for behavioural benefits of psychedelics.	Woodburn SC et al.	—	2023	→
Towards translational optogenetics.	Bansal A et al.	—	2023	→
Updates on the Physiopathology of Group I Metabotropic Glutamate Receptors (mGluRI)-Dependent Long-Term Depression.	Mango D et al.	—	2023	→
Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA.	Yang J et al.	—	2023	→
VTA multifaceted modulation of CA1 local circuits.	Adeyelu T et al.	—	2023	→
White matter integrity and medication response to antidepressants in major depressive disorder: a review of the literature.	Videtta G et al.	—	2023	→
Whole-brain tracking of cocaine and sugar rewards processing.	Bijoch Ł et al.	—	2023	→
α2δ-1 protein drives opioid-induced conditioned reward and synaptic NMDA receptor hyperactivity in the nucleus accumbens.	Jin D et al.	—	2023	→
Alcohol Use Disorder: Neurobiology and Therapeutics.	Yang W et al.	—	2022	→
A mechanistic overview of approaches for the treatment of psychostimulant dependence.	Jensen KL et al.	—	2022	→
An extended amygdala-midbrain circuit controlling cocaine withdrawal-induced anxiety and reinstatement.	Tian G et al.	—	2022	→
An inhibitory brainstem input to dopamine neurons encodes nicotine aversion.	Liu C et al.	—	2022	→
An integrated cytokine and kynurenine network as the basis of neuroimmune communication.	Stone TW et al.	—	2022	→
A Novel CaMKII Inhibitory Peptide Blocks Relapse to Morphine Seeking by Influencing Synaptic Plasticity in the Nucleus Accumbens Shell.	Liu Z et al.	—	2022	→
A novel microRNA, novel-m009C, regulates methamphetamine rewarding effects.	Zhu L et al.	—	2022	→
Cell-type- and region-specific modulation of cocaine seeking by micro-RNA-1 in striatal projection neurons.	Forget B et al.	—	2022	→
Chemogenetic modulation reveals distinct roles of the subthalamic nucleus and its afferents in the regulation of locomotor sensitization to amphetamine in rats.	Nakata KG et al.	—	2022	→
Chronic cocaine causes age-dependent increases in risky choice in both males and females.	Blaes SL et al.	—	2022	→
Chronic Δ9-tetrahydrocannabinol impact on plasticity, and differential activation requirement for CB1-dependent long-term depression in ventral tegmental area GABA neurons in adult versus young mice.	Ostlund I et al.	—	2022	→
Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus accumbens.	Shelkar GP et al.	—	2022	→
Control of complex behavior by astrocytes and microglia.	Ortinski PI et al.	—	2022	→
Dopamine Receptors: Is It Possible to Become a Therapeutic Target for Depression?	Zhao F et al.	—	2022	→
Dopaminergic Neurons in the Ventral Tegmental-Prelimbic Pathway Promote the Emergence of Rats from Sevoflurane Anesthesia.	Song Y et al.	—	2022	→
Dual action of ketamine confines addiction liability.	Simmler LD et al.	—	2022	→
Early social isolation stress increases addiction vulnerability to heroin and alters c-Fos expression in the mesocorticolimbic system.	Singh A et al.	—	2022	→
Efficacy of continuous theta burst stimulation - repetitive trancranial magnetic stimulation on the orbito frontal cortex as an adjunct to naltrexone in patients of opioid use disorder and its correlation with serum BDNF levels: a sham-controlled study.	Ankit A et al.	—	2022	→
Endocannabinoid-mediated synaptic plasticity and substance use disorders.	Fernández-Espejo E et al.	—	2022	→
Enhanced psychostimulant response, but not social avoidance, depends on GluA1 AMPA receptors in VTA dopamine neurons following intermittent social defeat stress in rats.	Rudolph ML et al.	—	2022	→
Extrasynaptic therapeutic targets in substance use and stress disorders.	Hodebourg R et al.	—	2022	→
FOXN3 and GDNF Polymorphisms as Common Genetic Factors of Substance Use and Addictive Behaviors.	Vereczkei A et al.	—	2022	→
GABA<sub>B</sub> Receptors and Drug Addiction: Psychostimulants and Other Drugs of Abuse.	Li X et al.	—	2022	→
Glutamate receptor-interacting protein 1 in D1- and D2-dopamine receptor-expressing medium spiny neurons differentially regulates cocaine acquisition, reinstatement, and associated spine plasticity.	Chen H et al.	—	2022	→
High throughput 3D gel-based neural organotypic model for cellular assays using fluorescence biosensors.	Kundu S et al.	—	2022	→
Investigating the Influence of GABA Neurons on Dopamine Neurons in the Ventral Tegmental Area Using Optogenetic Techniques.	Ohta Y et al.	—	2022	→
Lower dACC glutamate in cannabis users during early phase abstinence.	Zuo CS et al.	—	2022	→
Molecular mechanism and candidate biomarkers of morphine for analgesia and addiction effects.	Wang T et al.	—	2022	→
mTOR regulates cocaine-induced behavioural sensitization through the SynDIG1-GluA2 interaction in the nucleus accumbens.	Li HC et al.	—	2022	→
Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain.	Reeves KC et al.	—	2022	→
Optical Activation of TrkB (E281A) in Excitatory and Inhibitory Neurons of the Mouse Visual Cortex.	Lilja A et al.	—	2022	→
Postsynaptic plasticity of cholinergic synapses underlies the induction and expression of appetitive and familiarity memories in <i>Drosophila</i>.	Pribbenow C et al.	—	2022	→
Repeated ketamine anesthesia during neurodevelopment upregulates hippocampal activity and enhances drug reward in male mice.	Cui J et al.	—	2022	→
Subanesthetic Dose of Propofol Activates the Reward System in Rats.	Nagata I et al.	—	2022	→
Tactile Stimulation in Adult Rats Modulates Dopaminergic Molecular Parameters in the Nucleus accumbens Preventing Amphetamine Relapse.	Rossato DR et al.	—	2022	→
Targeting the kinetics mechanism of AMPA receptor inhibition by 2-oxo-3H-benzoxazole derivatives.	Qneibi M et al.	—	2022	→
The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus.	Puri NM et al.	—	2022	→
Activation of peroxisome proliferator-activated receptor γ reduces alcohol drinking and seeking by modulating multiple mesocorticolimbic regions in rats.	Fotio Y et al.	—	2021	→
Acute cocaine exposure occludes long-term depression in ventral tegmental area GABA neurons.	Friend LN et al.	—	2021	→
Acute morphine blocks spinal respiratory motor plasticity via long-latency mechanisms that require toll-like receptor 4 signalling.	Tadjalli A et al.	—	2021	→
Addiction and the kynurenine pathway: A new dancing couple?	Morales-Puerto N et al.	—	2021	→
Addiction as a brain disease revised: why it still matters, and the need for consilience.	Heilig M et al.	—	2021	→
Advances in Targeting GIRK Channels in Disease.	Zhao Y et al.	—	2021	→
Alteration of CYP2E1, DBN1, DNMT1, miRNA-335, miRNA-21, c-Fos and Cox-2 gene expression in prefrontal cortex of rats' offspring submitted to prenatal ethanol exposure during their neurodevelopment and the preventive role of nancocurcumin administration: A histological, ultrastructural and molecular study.	Labib HMA	—	2021	→
A narrative review of highly processed food addiction across the lifespan.	Schiestl ET et al.	—	2021	→
A Novel Peripheral Action of PICK1 Inhibition in Inflammatory Pain.	Jensen KL et al.	—	2021	→
A systems omics-based approach to decode substance use disorders and neuroadaptations.	Veerappa A et al.	—	2021	→
Cell-type specialization is encoded by specific chromatin topologies.	Winick-Ng W et al.	—	2021	→
Cell-Type-Specific Adaptions in Striatal Medium-Sized Spiny Neurons and Their Roles in Behavioral Responses to Drugs of Abuse.	Allichon MC et al.	—	2021	→
Chronic nicotine increases midbrain dopamine neuron activity and biases individual strategies towards reduced exploration in mice.	Dongelmans M et al.	—	2021	→
Circuit selectivity in drug versus natural reward seeking behaviors.	Nall RW et al.	—	2021	→
Cocaine induces paradigm-specific changes to the transcriptome within the ventral tegmental area.	Campbell RR et al.	—	2021	→
Cocaine shifts dopamine D2 receptor sensitivity to gate conditioned behaviors.	Gong S et al.	—	2021	→
Contributions of neuroimmune and gut-brain signaling to vulnerability of developing substance use disorders.	Lucerne KE et al.	—	2021	→
CRH<sup>CeA→VTA</sup> inputs inhibit the positive ensembles to induce negative effect of opiate withdrawal.	Jiang C et al.	—	2021	→
Cues conditioned to withdrawal and negative reinforcement: Neglected but key motivational elements driving opioid addiction.	Pantazis CB et al.	—	2021	→
Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine's rewarding effects but preserves natural reward processing.	Andrianarivelo A et al.	—	2021	→
Dopamine Circuit Mechanisms of Addiction-Like Behaviors.	Poisson CL et al.	—	2021	→
Dopamine D<sub>4</sub> Receptor Is a Regulator of Morphine-Induced Plasticity in the Rat Dorsal Striatum.	Rivera A et al.	—	2021	→
Drug-activated cells: From immediate early genes to neuronal ensembles in addiction.	Salery M et al.	—	2021	→
Drug-Evoked Synaptic Plasticity of Excitatory Transmission in the Ventral Tegmental Area.	Bellone C et al.	—	2021	→
Dual-specificity phosphatase 15 (DUSP15) in the nucleus accumbens is a novel negative regulator of morphine-associated contextual memory.	Qiao X et al.	—	2021	→
Early life adversity promotes resilience to opioid addiction-related phenotypes in male rats and sex-specific transcriptional changes.	Ordoñes Sanchez E et al.	—	2021	→
Effect of chronic ethanol consumption in rhesus macaques on the nucleus accumbens core transcriptome.	Walter N et al.	—	2021	→
Effects of chemogenetic manipulation of the nucleus accumbens core in male C57BL/6J mice.	Townsley KG et al.	—	2021	→
Egr2 induction in spiny projection neurons of the ventrolateral striatum contributes to cocaine place preference in mice.	Mukherjee D et al.	—	2021	→
Epigenetic landscape of stress surfeit disorders: Key role for DNA methylation dynamics.	Gatta E et al.	—	2021	→
Exercise craving potentiates excitatory inputs to ventral tegmental area dopaminergic neurons.	Medrano MC et al.	—	2021	→
Framework for internal sensation of pleasure using constraints from disparate findings in nucleus accumbens.	Vadakkan KI	—	2021	→
Glutamatergic Systems and Memory Mechanisms Underlying Opioid Addiction.	Heinsbroek JA et al.	—	2021	→
Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons.	Squires KE et al.	—	2021	→
Identifying knowledge important to teach about the nervous system in the context of secondary biology and science education-A Delphi study.	Kvello P et al.	—	2021	→
Impaired glutamate homeostasis in the nucleus accumbens in human cocaine addiction.	Engeli EJE et al.	—	2021	→
Influence of Dopamine on Fluorescent Advanced Glycation End Products Formation Using <i>Drosophila melanogaster</i>.	Filošević Vujnović A et al.	—	2021	→
Integrating the Roles of Midbrain Dopamine Circuits in Behavior and Neuropsychiatric Disease.	Chen APF et al.	—	2021	→
Investigating the effects of chronic perinatal alcohol and combined nicotine and alcohol exposure on dopaminergic and non-dopaminergic neurons in the VTA.	Kazemi T et al.	—	2021	→
Ketamine induces opposite changes in AMPA receptor calcium permeability in the ventral tegmental area and nucleus accumbens.	Skiteva O et al.	—	2021	→
Loss of mGluR1-LTD following cocaine exposure accumulates Ca<sup>2+</sup>-permeable AMPA receptors and facilitates synaptic potentiation in the prefrontal cortex.	Ruan H et al.	—	2021	→
Maternal Morphine Exposure and Post-Weaning Social Isolation Impair Memory and Ventral Striatum Dopamine System in Male Offspring: Is an Enriched Environment Beneficial?	Yazdanfar N et al.	—	2021	→
Metabotropic glutamate type 5 receptor binding availability during dextroamphetamine sensitization in mice and humans.	Smart K et al.	—	2021	→
Methylation quantitative trait locus rs5326 is associated with susceptibility and effective dosage of methadone maintenance treatment for heroin use disorder.	Zhang J et al.	—	2021	→
Microenvironmental interactions of oligodendroglial cells.	Yalçın B et al.	—	2021	→
Mitochondria-Related Nuclear Gene Expression in the Nucleus Accumbens and Blood Mitochondrial Copy Number After Developmental Fentanyl Exposure in Adolescent Male and Female C57BL/6 Mice.	Calarco CA et al.	—	2021	→
NMDA Receptors in Accumbal D1 Neurons Influence Chronic Sugar Consumption and Relapse.	Wei S et al.	—	2021	→
Noradrenergic Signaling Disengages Feedforward Transmission in the Nucleus Accumbens Shell.	Manz KM et al.	—	2021	→
Opioid-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area Dopamine Neurons.	Doyle MA et al.	—	2021	→
Opioid-induced structural and functional plasticity of medium-spiny neurons in the nucleus accumbens.	Thompson BL et al.	—	2021	→
Optogenetic induction of orbitostriatal long-term potentiation in the dorsomedial striatum elicits a persistent reduction of alcohol-seeking behavior in rats.	Cheng Y et al.	—	2021	→
Oxytocin and Addiction: Potential Glutamatergic Mechanisms.	Sundar M et al.	—	2021	→
Protracted Abstinence From Extended Cocaine Self-Administration Is Associated With Hypodopaminergic Activity in the VTA but Not in the SNc.	Salin A et al.	—	2021	→
Psychostimulant Use Disorder, an Unmet Therapeutic Goal: Can Modafinil Narrow the Gap?	Hersey M et al.	—	2021	→
Reduced cue-induced reinstatement of cocaine-seeking behavior in Plcb1 +/- mice.	Cabana-Domínguez J et al.	—	2021	→
Regulation of dopamine-dependent transcription and cocaine action by Gadd45b.	Zipperly ME et al.	—	2021	→
Reinstatement of synaptic plasticity in the aging brain through specific dopamine transporter inhibition.	Lubec J et al.	—	2021	→
Repeated morphine exposure activates synaptogenesis and other neuroplasticity-related gene networks in the dorsomedial prefrontal cortex of male and female rats.	Liu SX et al.	—	2021	→
Rhythms, Reward, and Blues: Consequences of Circadian Photoperiod on Affective and Reward Circuit Function.	Siemann JK et al.	—	2021	→
Roles of dopamine and glutamate co-release in the nucleus accumbens in mediating the actions of drugs of abuse.	Buck SA et al.	—	2021	→
SNP rs10420324 in the AMPA receptor auxiliary subunit TARP γ-8 regulates the susceptibility to antisocial personality disorder.	Peng SX et al.	—	2021	→
Striatal activation to monetary reward is associated with alcohol reward sensitivity.	Radoman M et al.	—	2021	→
Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction.	Li Y et al.	—	2021	→
The changing opioid crisis: development, challenges and opportunities.	Volkow ND et al.	—	2021	→
Therapeutic potential of ketamine for alcohol use disorder.	Worrell SD et al.	—	2021	→
The role of gut-immune-brain signaling in substance use disorders.	Lucerne KE et al.	—	2021	→
Tonic GABAergic inhibition, via GABA<sub>A</sub> receptors containing αβƐ subunits, regulates excitability of ventral tegmental area dopamine neurons.	Tossell K et al.	—	2021	→
Transcriptional signatures in prefrontal cortex confer vulnerability versus resilience to food and cocaine addiction-like behavior.	Navandar M et al.	—	2021	→
Trophic factors as potential therapies for treatment of major mental disorders.	Dremencov E et al.	—	2021	→
Ventral pallidum DRD3 potentiates a pallido-habenular circuit driving accumbal dopamine release and cocaine seeking.	Pribiag H et al.	—	2021	→
Whole-Brain Mapping of Direct Inputs to Dopamine D1 and D2 Receptor-Expressing Medium Spiny Neurons in the Posterior Dorsomedial Striatum.	Lu J et al.	—	2021	→
2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.	Lee YJ et al.	—	2020	→
Absence of methamphetamine-induced conditioned place preference in weaver mutant mice.	Ikekubo Y et al.	—	2020	→
A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain.	Christensen NR et al.	—	2020	→
Alpha-1 Adrenergic Receptors Modulate Glutamate and GABA Neurotransmission onto Ventral Tegmental Dopamine Neurons during Cocaine Sensitization.	Velasquez-Martinez MC et al.	—	2020	→
Altered Corticolimbic Control of the Nucleus Accumbens by Long-term Δ<sup>9</sup>-Tetrahydrocannabinol Exposure.	Hwang EK et al.	—	2020	→
Anterior Cingulate Cortex in Addiction: New Insights for Neuromodulation.	Zhao Y et al.	—	2020	→
A review of peripheral brain-derived neurotrophic factor levels in alcohol-dependent patients: Current understanding.	Kethawath SM et al.	—	2020	→
Arousal State-Dependent Alterations in VTA-GABAergic Neuronal Activity.	Eban-Rothschild A et al.	—	2020	→
Biomarkers and neuromodulation techniques in substance use disorders.	Habelt B et al.	—	2020	→
Blockade of D3 receptor prevents changes in DAT and D3R expression in the mesolimbic dopaminergic circuit produced by social stress- and cocaine prime-induced reinstatement of cocaine-CPP.	Guerrero-Bautista R et al.	—	2020	→
Circuits and functions of the lateral habenula in health and in disease.	Hu H et al.	—	2020	→
Cocaine addicted rats show reduced neural activity as revealed by manganese-enhanced MRI.	Cannella N et al.	—	2020	→
Cocaine engages a non-canonical, dopamine-independent, mechanism that controls neuronal excitability in the nucleus accumbens.	Delint-Ramirez I et al.	—	2020	→
Cocaine-mediated circadian reprogramming in the striatum through dopamine D2R and PPARγ activation.	Brami-Cherrier K et al.	—	2020	→
Cocaine self-administration abolishes endocannabinoid-mediated long-term depression of glutamatergic synapses in the ventral tegmental area.	Wang R et al.	—	2020	→
Comprehensive Genome-Wide Approaches to Activity-Dependent Translational Control in Neurons.	Choe HK et al.	—	2020	→
Computational models of drug use and addiction: A review.	Mollick JA et al.	—	2020	→
Deep brain stimulation of the infralimbic cortex attenuates cocaine priming-induced reinstatement of drug seeking.	Guercio LA et al.	—	2020	→
Differential Roles of Intra-accumbal Orexin Receptors in Acquisition and Expression of Methamphetamine-Induced Conditioned Place Preference in the Rats.	Khosrowabadi E et al.	—	2020	→
Dopamine and Addiction.	Wise RA et al.	—	2020	→
Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity.	Corkrum M et al.	—	2020	→
Dopaminergic Regulation of Nucleus Accumbens Cholinergic Interneurons Demarcates Susceptibility to Cocaine Addiction.	Lee JH et al.	—	2020	→
Endocannabinoid LTD in Accumbal D1 Neurons Mediates Reward-Seeking Behavior.	Bilbao A et al.	—	2020	→
Epigenetic tinkering with neurotransmitters.	Girault JA	—	2020	→
Exogenous Orexin-A Microinjected Into Central Nucleus of the Amygdala Modulates Feeding and Gastric Motility in Rats.	Jin T et al.	—	2020	→
From Signaling Molecules to Circuits and Behaviors: Cell-Type-Specific Adaptations to Psychostimulant Exposure in the Striatum.	Salery M et al.	—	2020	→
Glycogen synthase kinase-3 signaling in cellular and behavioral responses to psychostimulant drugs.	Barr JL et al.	—	2020	→
Growth Factors and Alcohol Use Disorder.	Liran M et al.	—	2020	→
Impaired effective functional connectivity of the sensorimotor network in interictal episodic migraineurs without aura.	Wei HL et al.	—	2020	→
Modelling Differential Vulnerability to Substance Use Disorder in Rodents: Neurobiological Mechanisms.	Jupp B et al.	—	2020	→
Modulatory Effects of Food Restriction on Brain and Behavioral Effects of Abused Drugs.	Carr KD	—	2020	→
Morphine selectively disinhibits glutamatergic input from mPFC onto dopamine neurons of VTA, inducing reward.	Yang L et al.	—	2020	→
Multiple sources of internal calcium stores mediate ethanol-induced presynaptic inhibitory GABA release in the central nucleus of the amygdala in mice.	Li Q et al.	—	2020	→
Oxidative Stress and Neuroinflammation as a Pivot in Drug Abuse. A Focus on the Therapeutic Potential of Antioxidant and Anti-Inflammatory Agents and Biomolecules.	Berríos-Cárcamo P et al.	—	2020	→
Plasticity in the Brainstem: Prenatal and Postnatal Experience Can Alter Laterodorsal Tegmental (LDT) Structure and Function.	Kohlmeier KA et al.	—	2020	→
Prenatal Opioid Exposure Enhances Responsiveness to Future Drug Reward and Alters Sensitivity to Pain: A Review of Preclinical Models and Contributing Mechanisms.	Grecco GG et al.	—	2020	→
Relapse-Associated Transient Synaptic Potentiation Requires Integrin-Mediated Activation of Focal Adhesion Kinase and Cofilin in D1-Expressing Neurons.	Garcia-Keller C et al.	—	2020	→
Repeated ethanol exposure influences key enzymes in cholesterol and lipid homeostasis via the AMPK pathway in the rat prefrontal cortex.	Xu S et al.	—	2020	→
Role of conduct problems in the relation between Attention-Deficit Hyperactivity disorder, substance use, and gaming.	Schoenmacker GH et al.	—	2020	→
Role of densin-180 in mouse ventral hippocampal neurons in 24-hr retention of contextual fear conditioning.	Kim CH et al.	—	2020	→
SYNPLA, a method to identify synapses displaying plasticity after learning.	Dore K et al.	—	2020	→
Thalamic Retrieval of Opioid Memories.	Pribiag H et al.	—	2020	→
The effects of repetitive transcranial magnetic stimulation on cue-induced craving in male patients with heroin use disorder.	Liu X et al.	—	2020	→
The Impact of Electronic Nicotine Delivery System (ENDS) Flavors on Nicotinic Acetylcholine Receptors and Nicotine Addiction-Related Behaviors.	Cooper SY et al.	—	2020	→
The loss of NMDAR-dependent LTD following cannabinoid self-administration is restored by positive allosteric modulation of CB1 receptors.	Neuhofer D et al.	—	2020	→
The non-receptor tyrosine kinase Pyk2 modulates acute locomotor effects of cocaine in D1 receptor-expressing neurons of the nucleus accumbens.	de Pins B et al.	—	2020	→
The Nucleus Accumbens: A Common Target in the Comorbidity of Depression and Addiction.	Xu L et al.	—	2020	→
Transcriptional Profiling of Whisker Follicles and of the Striatum in Methamphetamine Self-Administered Rats.	Jang WJ et al.	—	2020	→
Translational Molecular Approaches in Substance Abuse Research.	Fulton SL et al.	—	2020	→
Ubiquitin biology in neurodegenerative disorders: From impairment to therapeutic strategies.	Kumar D et al.	—	2020	→
µ-Opioid receptor-induced synaptic plasticity in dopamine neurons mediates the rewarding properties of anabolic androgenic steroids.	Bontempi L et al.	—	2020	→
A competitive model for striatal action selection.	Bariselli S et al.	—	2019	→
Acute Tramadol-Induced Cellular Tolerance and Dependence of Ventral Tegmental Area Dopaminergic Neurons: An In Vivo Electrophysiological Study.	Khodayari S et al.	—	2019	→
Alcohol intake enhances glutamatergic transmission from D2 receptor-expressing afferents onto D1 receptor-expressing medium spiny neurons in the dorsomedial striatum.	Lu J et al.	—	2019	→
Alcohol Interaction with Cocaine, Methamphetamine, Opioids, Nicotine, Cannabis, and γ-Hydroxybutyric Acid.	Singh AK	—	2019	→
A novel neurobehavioral framework of the effects of positive early postnatal experience on incentive and consummatory reward sensitivity.	Fu Y et al.	—	2019	→
A potential mechanism for first-person internal sensation of memory provides evidence for the relationship between learning and LTP induction.	Vadakkan KI	—	2019	→
A VTA GABAergic Neural Circuit Mediates Visually Evoked Innate Defensive Responses.	Zhou Z et al.	—	2019	→
Cell-type and projection-specific dopaminergic encoding of aversive stimuli in addiction.	Thibeault KC et al.	—	2019	→
Cell-Type-Specific Regulation of Nucleus Accumbens Synaptic Plasticity and Cocaine Reward Sensitivity by the Circadian Protein, NPAS2.	Parekh PK et al.	—	2019	→
Cell type-specific transcriptional programs in mouse prefrontal cortex during adolescence and addiction.	Bhattacherjee A et al.	—	2019	→
Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse.	Mahler SV et al.	—	2019	→
Comparison between dopaminergic and non-dopaminergic neurons in the VTA following chronic nicotine exposure during pregnancy.	Keller RF et al.	—	2019	→
Differential Nicotinic Modulation of Glutamatergic and GABAergic VTA Microcircuits.	Yan Y et al.	—	2019	→
Distinct neural mechanisms for the prosocial and rewarding properties of MDMA.	Heifets BD et al.	—	2019	→
Dopamine and addiction: what have we learned from 40 years of research.	Solinas M et al.	—	2019	→
Dorsal Striatal Circuits for Habits, Compulsions and Addictions.	Lipton DM et al.	—	2019	→
Dorsolateral striatal miR-134 modulates excessive methamphetamine intake in self-administering rats.	Shi JJ et al.	—	2019	→
Elevated dopamine signaling from ventral tegmental area to prefrontal cortical parvalbumin neurons drives conditioned inhibition.	Yan R et al.	—	2019	→
Ethanol Experience Enhances Glutamatergic Ventral Hippocampal Inputs to D1 Receptor-Expressing Medium Spiny Neurons in the Nucleus Accumbens Shell.	Kircher DM et al.	—	2019	→
Ethanol-induced conditioned place preference and aversion differentially alter plasticity in the bed nucleus of stria terminalis.	Pati D et al.	—	2019	→
Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook.	Singh L et al.	—	2019	→
Exposure to conditions of uncertainty promotes the pursuit of amphetamine.	Mascia P et al.	—	2019	→
Extracellular Matrix Signaling Through β3 Integrin Mediates Cocaine Cue-Induced Transient Synaptic Plasticity and Relapse.	Garcia-Keller C et al.	—	2019	→
From controlled to compulsive drug-taking: The role of the habenula in addiction.	Mathis V et al.	—	2019	→
Glial mechanisms underlying substance use disorders.	Linker KE et al.	—	2019	→
Heterosynaptic GABA<sub>B</sub> Receptor Function within Feedforward Microcircuits Gates Glutamatergic Transmission in the Nucleus Accumbens Core.	Manz KM et al.	—	2019	→
Long non-coding RNA MEG3 attends to morphine-mediated autophagy of HT22 cells through modulating ERK pathway.	Gao S et al.	—	2019	→
Molecular Plasticity of the Nucleus Accumbens Revisited-Astrocytic Waves Shall Rise.	Kardos J et al.	—	2019	→
Molecular windows into the human brain for psychiatric disorders.	Egervari G et al.	—	2019	→
Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function.	Goldberg LR et al.	—	2019	→
NAD+ cellular redox and SIRT1 regulate the diurnal rhythms of tyrosine hydroxylase and conditioned cocaine reward.	Logan RW et al.	—	2019	→
Neuromodulation of Spike-Timing-Dependent Plasticity: Past, Present, and Future.	Brzosko Z et al.	—	2019	→
Neuroplasticity in cholinergic neurons of the laterodorsal tegmental nucleus contributes to the development of cocaine addiction.	Kaneda K	—	2019	→
NGF, BDNF and Arc mRNA Expression in the Hippocampus of Rats After Administration of Morphine.	Rouhani F et al.	—	2019	→
NMDA receptor-dependent plasticity in the nucleus accumbens connects reward-predictive cues to approach responses.	Vega-Villar M et al.	—	2019	→
Oxytocin-dependent reopening of a social reward learning critical period with MDMA.	Nardou R et al.	—	2019	→
Prenatal ethanol exposure increases risk of psychostimulant addiction.	Wang R et al.	—	2019	→
Prepulse Inhibition of the Startle Reflex as a Predictor of Vulnerability to Develop Locomotor Sensitization to Cocaine.	Arenas MC et al.	—	2019	→
Rostral and Caudal Ventral Tegmental Area GABAergic Inputs to Different Dorsal Raphe Neurons Participate in Opioid Dependence.	Li Y et al.	—	2019	→
Selective dopamine D3 receptor antagonist YQA14 inhibits morphine-induced behavioral sensitization in wild type, but not in dopamine D3 receptor knockout mice.	Lv Y et al.	—	2019	→
Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity, and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway.	Yohn SE et al.	—	2019	→
The paraventricular thalamic nucleus: A key hub of neural circuits underlying drug addiction.	Zhou K et al.	—	2019	→
The Projection Targets of Medium Spiny Neurons Govern Cocaine-Evoked Synaptic Plasticity in the Nucleus Accumbens.	Baimel C et al.	—	2019	→
The Role of Epigenetics in Addiction: Clinical Overview and Recent Updates.	Beayno A et al.	—	2019	→
The Role of Ghrelin in Regulating Synaptic Function and Plasticity of Feeding-Associated Circuits.	Serrenho D et al.	—	2019	→
[The roles of habenula and related neural circuits in neuropsychiatric diseases].	Wu Y et al.	—	2019	→
The Sigma-1 Receptor: When Adaptive Regulation of Cell Electrical Activity Contributes to Stimulant Addiction and Cancer.	Soriani O et al.	—	2019	→
TrkB-dependent disinhibition of the nucleus accumbens is enhanced by ethanol.	Patton MH et al.	—	2019	→
Addictive behaviour in experimental animals: prospects for translation.	Everitt BJ et al.	—	2018	→
Allopregnanolone involvement in feeding regulation, overeating and obesity.	Holmberg E et al.	—	2018	→
Altered GluA1 (Gria1) Function and Accumbal Synaptic Plasticity in the ClockΔ19 Model of Bipolar Mania.	Parekh PK et al.	—	2018	→
Altering gain of the infralimbic-to-accumbens shell circuit alters economically dissociable decision-making algorithms.	Sweis BM et al.	—	2018	→
Assessing the Effects of Opioids on Pathological Memory by a Computational Model.	Borjkhani M et al.	—	2018	→
Behavioral phenotyping and dopamine dynamics in mice with conditional deletion of the glutamate transporter GLT-1 in neurons: resistance to the acute locomotor effects of amphetamine.	Fischer KD et al.	—	2018	→
Beyond simple tests of value: measuring addiction as a heterogeneous disease of computation-specific valuation processes.	Sweis BM et al.	—	2018	→
Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD.	Ma T et al.	—	2018	→
Central Executive and Default Mode Network Intranet work Functional Connectivity Patterns in Chronic Migraine.	Androulakis XM et al.	—	2018	→
Chemogenetic Excitation of Accumbens-Projecting Infralimbic Cortical Neurons Blocks Toluene-Induced Conditioned Place Preference.	Wayman WN et al.	—	2018	→
Cocaine increases dopaminergic connectivity in the nucleus accumbens.	Dos Santos M et al.	—	2018	→
Cocaine-induced locomotor sensitization associates with slow oscillatory firing of neurons in the ventral tegmental area.	Liu CL et al.	—	2018	→
Cocaine-Induced Structural Plasticity in Input Regions to Distinct Cell Types in Nucleus Accumbens.	Barrientos C et al.	—	2018	→
Deletion of <i>Maged1</i> in mice abolishes locomotor and reinforcing effects of cocaine.	De Backer JF et al.	—	2018	→
Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of dopamine D1 receptors.	van der Kooij MA et al.	—	2018	→
Dopamine D1 or D2 receptor-expressing neurons in the central nervous system.	Wei X et al.	—	2018	→
Endogenous dopamine and endocannabinoid signaling mediate cocaine-induced reversal of AMPAR synaptic potentiation in the nucleus accumbens shell.	Ingebretson AE et al.	—	2018	→
Ethanol Modulates Glutamatergic Transmission and NMDAR-Mediated Synaptic Plasticity in the Agranular Insular Cortex.	Shillinglaw JE et al.	—	2018	→
Event-Related Potentials as Biomarkers of Behavior Change Mechanisms in Substance Use Disorder Treatment.	Houston RJ et al.	—	2018	→
Extinction and Reinstatement of Cocaine-seeking in Self-administering Mice is Associated with Bidirectional AMPAR-mediated Plasticity in the Nucleus Accumbens Shell.	Ebner SR et al.	—	2018	→
GABA Uptake Inhibition Reduces In Vivo Extraction Fraction in the Ventral Tegmental Area of Long Evans Rats Measured by Quantitative Microdialysis Under Transient Conditions.	Zandy SL et al.	—	2018	→
GABRA2 rs279858-linked variants are associated with disrupted structural connectome of reward circuits in heroin abusers.	Sun Y et al.	—	2018	→
Generation of silent synapses in dentate gyrus correlates with development of alcohol addiction.	Beroun A et al.	—	2018	→
Genetic inhibition of neurotransmission reveals role of glutamatergic input to dopamine neurons in high-effort behavior.	Hutchison MA et al.	—	2018	→
GIRK currents in VTA dopamine neurons control the sensitivity of mice to cocaine-induced locomotor sensitization.	Rifkin RA et al.	—	2018	→
Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens.	Liu J et al.	—	2018	→
Glutamate Transmission to Ventral Tegmental Area GABA Neurons Is Altered by Acute and Chronic Ethanol.	Williams SB et al.	—	2018	→
Hippocampal-Evoked Feedforward Inhibition in the Nucleus Accumbens.	Scudder SL et al.	—	2018	→
Implication of Genes for the N-Methyl-D-Aspartate (NMDA) Receptor in Substance Addictions.	Chen J et al.	—	2018	→
Interaction Between Stress and Addiction: Contributions From Latin-American Neuroscience.	Torres-Berrio A et al.	—	2018	→
Interactions between estrogen receptors and metabotropic glutamate receptors and their impact on drug addiction in females.	Tonn Eisinger KR et al.	—	2018	→
Long-Term Plasticity of Neurotransmitter Release: Emerging Mechanisms and Contributions to Brain Function and Disease.	Monday HR et al.	—	2018	→
Long-term subregion-specific encoding of enhanced ethanol intake by D1DR medium spiny neurons of the nucleus accumbens.	Renteria R et al.	—	2018	→
Membrane estrogen receptor signaling impacts the reward circuitry of the female brain to influence motivated behaviors.	Tonn Eisinger KR et al.	—	2018	→
mGlu<sub>1</sub> and mGlu<sub>5</sub> modulate distinct excitatory inputs to the nucleus accumbens shell.	Turner BD et al.	—	2018	→
Modulation of salience network intranetwork resting state functional connectivity in women with chronic migraine.	Androulakis XM et al.	—	2018	→
Neuroepigenetics of Neurotrophin Signaling: Neurobiology of Anxiety and Affective Disorders.	Règue-Guyon M et al.	—	2018	→
Nucleus Accumbens Modulation in Reward and Aversion.	Klawonn AM et al.	—	2018	→
Opioid receptor and β-arrestin2 densities and distribution change after sexual experience in the ventral tegmental area of male rats.	Garduño-Gutiérrez R et al.	—	2018	→
Overexpression of Thioredoxin-1 Blocks Morphine-Induced Conditioned Place Preference Through Regulating the Interaction of γ-Aminobutyric Acid and Dopamine Systems.	Li X et al.	—	2018	→
Oxytocin as a Modulator of Synaptic Plasticity: Implications for Neurodevelopmental Disorders.	Rajamani KT et al.	—	2018	→
Periaqueductal efferents to dopamine and GABA neurons of the VTA.	Ntamati NR et al.	—	2018	→
Persistent Neuroadaptations in the Expression of Genes Involved in Cholesterol Homeostasis Induced by Chronic, Voluntary Alcohol Intake in Rats.	Alsebaaly J et al.	—	2018	→
Pharmacology of MDMA- and Amphetamine-Like New Psychoactive Substances.	Simmler LD et al.	—	2018	→
Prefrontal Recruitment Mitigates Risk-Taking Behavior in Human Immunodeficiency Virus-Infected Young Adults.	Smith RX et al.	—	2018	→
Rem2 stabilizes intrinsic excitability and spontaneous firing in visual circuits.	Moore AR et al.	—	2018	→
Riluzole Impairs Cocaine Reinstatement and Restores Adaptations in Intrinsic Excitability and GLT-1 Expression.	Sepulveda-Orengo MT et al.	—	2018	→
Role of Dopamine D2/D3 Receptors in Development, Plasticity, and Neuroprotection in Human iPSC-Derived Midbrain Dopaminergic Neurons.	Bono F et al.	—	2018	→
Several behavioral traits relevant for alcoholism are controlled by ɣ2 subunit containing GABA<sub>A</sub> receptors on dopamine neurons in mice.	Stojakovic A et al.	—	2018	→
Single-Cell RNA-Seq Uncovers a Robust Transcriptional Response to Morphine by Glia.	Avey D et al.	—	2018	→
Synaptic Plasticity in the Bed Nucleus of the Stria Terminalis: Underlying Mechanisms and Potential Ramifications for Reinstatement of Drug- and Alcohol-Seeking Behaviors.	Harris NA et al.	—	2018	→
Synaptic Plasticity in the Nucleus Accumbens: Lessons Learned from Experience.	Turner BD et al.	—	2018	→
Synaptic plasticity mechanisms common to learning and alcohol use disorder.	Lovinger DM et al.	—	2018	→
Targeting VGLUT2 in Mature Dopamine Neurons Decreases Mesoaccumbal Glutamatergic Transmission and Identifies a Role for Glutamate Co-release in Synaptic Plasticity by Increasing Baseline AMPA/NMDA Ratio.	Papathanou M et al.	—	2018	→
The nucleus accumbens and alcoholism: a target for deep brain stimulation.	Ho AL et al.	—	2018	→
The role of caveolin-1 in morphine-induced structural plasticity in primary cultured mouse cerebral cortical neurons.	Cui W et al.	—	2018	→
To Do or Not to Do: Dopamine, Affordability and the Economics of Opportunity.	Beeler JA et al.	—	2018	→
Validated multi-step approach for in vivo recording and analysis of optogenetically evoked glutamate in the mouse globus pallidus.	Viereckel T et al.	—	2018	→
Accumbens Mechanisms for Cued Sucrose Seeking.	Bobadilla AC et al.	—	2017	→
Activation of Pedunculopontine Glutamate Neurons Is Reinforcing.	Yoo JH et al.	—	2017	→
Activity-Regulated Cytoskeleton-Associated Protein Accumulates in the Nucleus in Response to Cocaine and Acts as a Brake on Chromatin Remodeling and Long-Term Behavioral Alterations.	Salery M et al.	—	2017	→
Addictions Neuroclinical Assessment: A reverse translational approach.	Kwako LE et al.	—	2017	→
Alcohol induces input-specific aberrant synaptic plasticity in the rat dorsomedial striatum.	Ma T et al.	—	2017	→
A preclinical model for identifying rats at risk of alcohol use disorder.	Jadhav KS et al.	—	2017	→
Autophosphorylation of alpha isoform of calcium/calmodulin-dependent kinase II regulates alcohol addiction-related behaviors.	Mijakowska Z et al.	—	2017	→
Beta-arrestin 1 regulation of reward-motivated behaviors and glutamatergic function.	Mittal N et al.	—	2017	→
Calcium-Impermeable NMDA Receptor: A Novel Target for Addiction.	Huang X et al.	—	2017	→
CB1-Dependent Long-Term Depression in Ventral Tegmental Area GABA Neurons: A Novel Target for Marijuana.	Friend L et al.	—	2017	→
Chemogenetic inhibition reveals midline thalamic nuclei and thalamo-accumbens projections mediate cocaine-seeking in rats.	Wunsch AM et al.	—	2017	→
Cocaine, cadherins and synaptic plasticity.	Valentinova K et al.	—	2017	→
Cocaine Promotes Coincidence Detection and Lowers Induction Threshold during Hebbian Associative Synaptic Potentiation in Prefrontal Cortex.	Ruan H et al.	—	2017	→
Commentary: Methamphetamine abuse impairs motor cortical plasticity and function.	Du X et al.	—	2017	→
Corticostriatal plasticity, neuronal ensembles, and regulation of drug-seeking behavior.	Bobadilla AC et al.	—	2017	→
Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol.	Becker JAJ et al.	—	2017	→
Distinct Synaptic Strengthening of the Striatal Direct and Indirect Pathways Drives Alcohol Consumption.	Cheng Y et al.	—	2017	→
Dopamine D3 and acetylcholine nicotinic receptor heteromerization in midbrain dopamine neurons: Relevance for neuroplasticity.	Bontempi L et al.	—	2017	→
Dopamine neuron dependent behaviors mediated by glutamate cotransmission.	Mingote S et al.	—	2017	→
Dopaminergic neurotransmission in ventral and dorsal striatum differentially modulates alcohol reinforcement.	Spoelder M et al.	—	2017	→
Early adverse experience and substance addiction: dopamine, oxytocin, and glucocorticoid pathways.	Kim S et al.	—	2017	→
Effect of optogenetic manipulation of accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization.	Kang BJ et al.	—	2017	→
Evaluation of the Abuse Potential of Novel Amphetamine Derivatives with Modifications on the Amine (NBNA) and Phenyl (EDA, PMEA, 2-APN) Sites.	Custodio RJP et al.	—	2017	→
Genome-wide analysis of the nucleus accumbens identifies DNA methylation signals differentiating low/binge from heavy alcohol drinking.	Cervera-Juanes R et al.	—	2017	→
Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse.	Lacagnina MJ et al.	—	2017	→
GluN1 deletions in D1- and A2A-expressing cell types reveal distinct modes of behavioral regulation.	Joffe ME et al.	—	2017	→
G Protein-Gated Potassium Channels: A Link to Drug Addiction.	Rifkin RA et al.	—	2017	→
Heroin Addiction Impairs Human Cortical Plasticity.	Shen Y et al.	—	2017	→
Intoxication and substance use disorder to Areca catechu nut containing betel quid: A review of epidemiological evidence, pharmacological basis and social factors influencing quitting strategies.	Osborne PG et al.	—	2017	→
Involvement of AMPA/Kainate Glutamate Receptor in the Extinction and Reinstatement of Morphine-Induced Conditioned Place Preference: A Behavioral and Molecular Study.	Siahposht-Khachaki A et al.	—	2017	→
Matrix Metalloproteinase-9 and Synaptic Plasticity in the Central Amygdala in Control of Alcohol-Seeking Behavior.	Stefaniuk M et al.	—	2017	→
Methamphetamine abuse impairs motor cortical plasticity and function.	Huang X et al.	—	2017	→
MiR-218 targets MeCP2 and inhibits heroin seeking behavior.	Yan B et al.	—	2017	→
Modulation of intrinsic resting-state fMRI networks in women with chronic migraine.	Androulakis XM et al.	—	2017	→
Morphine-induced inhibition of Ca<sup>2+</sup> -dependent d-serine release from astrocytes suppresses excitability of GABAergic neurons in the nucleus accumbens.	Wu J et al.	—	2017	→
Mothers with substance addictions show reduced reward responses when viewing their own infant's face.	Kim S et al.	—	2017	→
Neuronal plasticity and neurotrophic factors in drug responses.	Castrén E et al.	—	2017	→
Nicotine enhances alcohol intake and dopaminergic responses through β2* and β4* nicotinic acetylcholine receptors.	Tolu S et al.	—	2017	→
Obesogenic diet intake during pregnancy programs aberrant synaptic plasticity and addiction-like behavior to a palatable food in offspring.	Camacho A et al.	—	2017	→
Opiates and Plasticity in the Ventral Tegmental Area.	Langlois LD et al.	—	2017	→
Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats.	Lacagnina MJ et al.	—	2017	→
Psychostimulant effect of dopaminergic treatment and addictions in Parkinson's disease.	Delpont B et al.	—	2017	→
Rabies screen reveals GPe control of cocaine-triggered plasticity.	Beier KT et al.	—	2017	→
Re-exposure to morphine-associated context facilitated long-term potentiation in the vSUB-NAc glutamatergic pathway via GluN2B-containing receptor activation.	Li YJ et al.	—	2017	→
Resistance to ethanol sensitization is associated with a loss of synaptic plasticity in the hippocampus.	Coune F et al.	—	2017	→
Reward Circuitry in Addiction.	Cooper S et al.	—	2017	→
Role of DOR in neuronal plasticity changes promoted by food-seeking behaviour.	Mancino S et al.	—	2017	→
Selective alterations of NMDAR function and plasticity in D1 and D2 medium spiny neurons in the nucleus accumbens shell following chronic intermittent ethanol exposure.	Renteria R et al.	—	2017	→
Stable immediate early gene expression patterns in medial prefrontal cortex and striatum after long-term cocaine self-administration.	Gao P et al.	—	2017	→
Stroke triggers nigrostriatal plasticity and increases alcohol consumption in rats.	Huang CCY et al.	—	2017	→
Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins.	Greger IH et al.	—	2017	→
Synaptic Plasticity onto Dopamine Neurons Shapes Fear Learning.	Pignatelli M et al.	—	2017	→
Synergistic effect between D-AP5 and muscimol in the nucleus accumbens shell on memory consolidation deficit in adult male Wistar rats: An isobologram analysis.	Nasehi M et al.	—	2017	→
The genetic epidemiology of substance use disorder: A review.	Prom-Wormley EC et al.	—	2017	→
The Novel Modafinil Analog, JJC8-016, as a Potential Cocaine Abuse Pharmacotherapeutic.	Zhang HY et al.	—	2017	→
The relationship between the striatal dopamine transporter and novelty seeking and cognitive flexibility in opioid dependence.	Liang CS et al.	—	2017	→
The role of the habenula in the transition from reward to misery in substance use and mood disorders.	Batalla A et al.	—	2017	→
Transcriptomic profiling of the ventral tegmental area and nucleus accumbens in rhesus macaques following long-term cocaine self-administration.	Vallender EJ et al.	—	2017	→
Tumour necrosis factor-mediated homeostatic synaptic plasticity in behavioural models: testing a role in maternal immune activation.	Konefal SC et al.	—	2017	→
Update of neurotrophic factors in neurobiology of addiction and future directions.	Koskela M et al.	—	2017	→
Architectural Representation of Valence in the Limbic System.	Namburi P et al.	—	2016	→
A Role for the GIRK3 Subunit in Methamphetamine-Induced Attenuation of GABAB Receptor-Activated GIRK Currents in VTA Dopamine Neurons.	Munoz MB et al.	—	2016	→
Assessment of individual differences in the rat nucleus accumbens transcriptome following taste-heroin extended access.	Imperio CG et al.	—	2016	→
Cell-Type Specific Insertion of GluA2-Lacking AMPARs with Cocaine Exposure Leading to Sensitization, Cue-Induced Seeking, and Incubation of Craving.	Terrier J et al.	—	2016	→
Chronic cocaine exposure induces noradrenergic modulation of inhibitory synaptic transmission to cholinergic neurons of the laterodorsal tegmental nucleus.	Taoka N et al.	—	2016	→
Common Brain Mechanisms of Chronic Pain and Addiction.	Elman I et al.	—	2016	→
Corticostriatal Afferents Modulate Responsiveness to Psychostimulant Drugs and Drug-Associated Stimuli.	Kerstetter KA et al.	—	2016	→
Corticostriatal circuitry in regulating diseases characterized by intrusive thinking.	Kalivas BC et al.	—	2016	→
D1 receptor-mediated inhibition of medial prefrontal cortex neurons is disrupted in adult rats exposed to amphetamine in adolescence.	Kang S et al.	—	2016	→
Differential Control of Cocaine Self-Administration by GABAergic and Glutamatergic CB1 Cannabinoid Receptors.	Martín-García E et al.	—	2016	→
Differential Dopamine Regulation of Ca(2+) Signaling and Its Timing Dependence in the Nucleus Accumbens.	Swapna I et al.	—	2016	→
Dopamine D2/3- and μ-opioid receptor antagonists reduce cue-induced responding and reward impulsivity in humans.	Weber SC et al.	—	2016	→
Dopamine Replacement Therapy, Learning and Reward Prediction in Parkinson's Disease: Implications for Rehabilitation.	Ferrazzoli D et al.	—	2016	→
Drug Addiction: Updating Actions to Habits to Compulsions Ten Years On.	Everitt BJ et al.	—	2016	→
Effects of daily delta-9-tetrahydrocannabinol treatment on heroin self-administration in rhesus monkeys.	Maguire DR et al.	—	2016	→
eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons.	Placzek AN et al.	—	2016	→
Fasting induces a form of autonomic synaptic plasticity that prevents hypoglycemia.	Wang M et al.	—	2016	→
FMRP regulates an ethanol-dependent shift in GABA<sub>B</sub>R function and expression with rapid antidepressant properties.	Wolfe SA et al.	—	2016	→
Functional Relevance of Different Basal Ganglia Pathways Investigated in a Spiking Model with Reward Dependent Plasticity.	Berthet P et al.	—	2016	→
Group I Metabotropic Glutamate Receptor Interacting Proteins: Fine-Tuning Receptor Functions in Health and Disease.	Kalinowska M et al.	—	2016	→
Hijacking translation in addiction.	Izquierdo A et al.	—	2016	→
Ifenprodil Attenuates Methamphetamine-Induced Behavioral Sensitization and Activation of Ras-ERK-∆FosB Pathway in the Caudate Putamen.	Li L et al.	—	2016	→
Large-Scale, Ion-Current-Based Proteomic Investigation of the Rat Striatal Proteome in a Model of Short- and Long-Term Cocaine Withdrawal.	Shen S et al.	—	2016	→
Linking Cholinergic Interneurons, Synaptic Plasticity, and Behavior during the Extinction of a Cocaine-Context Association.	Lee J et al.	—	2016	→
Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization.	Lewitus GM et al.	—	2016	→
Morphine-induced locomotor sensitization produces structural plasticity in the mesocorticolimbic system dependent on CB1-R activity.	Guegan T et al.	—	2016	→
Neurobiology of addiction: a neurocircuitry analysis.	Koob GF et al.	—	2016	→
NMDA Receptors on Dopaminoceptive Neurons Are Essential for Drug-Induced Conditioned Place Preference.	Sikora M et al.	—	2016	→
Opposite effects of acute and chronic amphetamine on Nurr1 and NF-κB p65 in the rat ventral tegmental area.	Arredondo C et al.	—	2016	→
Optogenetic inhibition of cortical afferents in the nucleus accumbens simultaneously prevents cue-induced transient synaptic potentiation and cocaine-seeking behavior.	Stefanik MT et al.	—	2016	→
RACK1 promotes maintenance of morphine-associated memory via activation of an ERK-CREB dependent pathway in hippocampus.	Liu L et al.	—	2016	→
Reciprocal Inhibitory Interactions Between the Reward-Related Effects of Leptin and Cocaine.	You ZB et al.	—	2016	→
Regulation of dopaminergic markers expression in response to acute and chronic morphine and to morphine withdrawal.	García-Pérez D et al.	—	2016	→
Repeated Exposure to D-Amphetamine Decreases Global Protein Synthesis and Regulates the Translation of a Subset of mRNAs in the Striatum.	Biever A et al.	—	2016	→
Reversal of morphine-induced cell-type-specific synaptic plasticity in the nucleus accumbens shell blocks reinstatement.	Hearing MC et al.	—	2016	→
Reward and Aversion.	Hu H	—	2016	→
Sex differences in drug addiction and response to exercise intervention: From human to animal studies.	Zhou Y et al.	—	2016	→
Signals from the Fourth Dimension Regulate Drug Relapse.	Mulholland PJ et al.	—	2016	→
Stress and Cocaine Trigger Divergent and Cell Type-Specific Regulation of Synaptic Transmission at Single Spines in Nucleus Accumbens.	Khibnik LA et al.	—	2016	→
The Emergence of a Circuit Model for Addiction.	Lüscher C	—	2016	→
The Extracellular Matrix Protein Brevican Limits Time-Dependent Enhancement of Cocaine Conditioned Place Preference.	Lubbers BR et al.	—	2016	→
The good and bad news about glutamate in drug addiction.	Spencer S et al.	—	2016	→
The neurocircuitry involved in oxytocin modulation of methamphetamine addiction.	Baracz SJ et al.	—	2016	→
The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis.	Scofield MD et al.	—	2016	→
Transactivation of TrkB by Sigma-1 receptor mediates cocaine-induced changes in dendritic spine density and morphology in hippocampal and cortical neurons.	Ka M et al.	—	2016	→
Transgenerational Inheritance of Paternal Neurobehavioral Phenotypes: Stress, Addiction, Ageing and Metabolism.	Yuan TF et al.	—	2016	→
Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine.	Huang W et al.	—	2016	→
Using In Vitro Electrophysiology to Screen Medications: Accumbal Plasticity as an Engram of Alcohol Dependence.	Renteria R et al.	—	2016	→
Variation in the Oxytocin Receptor Gene Predicts Brain Region-Specific Expression and Social Attachment.	King LB et al.	—	2016	→
Ventral Tegmental Area Afferents and Drug-Dependent Behaviors.	Oliva I et al.	—	2016	→
Ventral tegmental area glutamate neurons co-release GABA and promote positive reinforcement.	Yoo JH et al.	—	2016	→
Voluntary adolescent drinking enhances excitation by low levels of alcohol in a subset of dopaminergic neurons in the ventral tegmental area.	Avegno EM et al.	—	2016	→
Whole-cell Patch-clamp Recordings in Brain Slices.	Segev A et al.	—	2016	→
Aberrant approach-avoidance conflict resolution following repeated cocaine pre-exposure.	Nguyen D et al.	—	2015	→
Addiction therapy. Refining deep brain stimulation to emulate optogenetic treatment of synaptic pathology.	Creed M et al.	—	2015	→
Amphetamine activates Rho GTPase signaling to mediate dopamine transporter internalization and acute behavioral effects of amphetamine.	Wheeler DS et al.	—	2015	→
A new automated 3D detection of synaptic contacts reveals the formation of cortico-striatal synapses upon cocaine treatment in vivo.	Heck N et al.	—	2015	→
A subset of ventral tegmental area dopamine neurons responds to acute ethanol.	Mrejeru A et al.	—	2015	→
Autism: Oxytocin, serotonin, and social reward.	Dölen G	—	2015	→
Between the primate and 'reptilian' brain: Rodent models demonstrate the role of corticostriatal circuits in decision making.	Lee AM et al.	—	2015	→
Cigarettes and alcohol: The influence of nicotine on operant alcohol self-administration and the mesolimbic dopamine system.	Ostroumov A et al.	—	2015	→
Cocaine exposure alters dopaminergic modulation of prefronto-accumbens transmission.	Wang X et al.	—	2015	→
Cocaine triggers epigenetic alterations in the corticostriatal circuit.	Sadri-Vakili G	—	2015	→
Cocaine Withdrawal Impairs mGluR5-Dependent Long-Term Depression in Nucleus Accumbens Shell Neurons of Both Direct and Indirect Pathways.	Huang CC et al.	—	2015	→
Corticostriatal BDNF and alcohol addiction.	Logrip ML et al.	—	2015	→
Cortico-striatal circuits: Novel therapeutic targets for substance use disorders.	Kravitz AV et al.	—	2015	→
Corticostriatal microRNAs in addiction.	Heyer MP et al.	—	2015	→
Differential roles of dopamine D1 and D2 receptor-containing neurons of the nucleus accumbens shell in behavioral sensitization.	Kai N et al.	—	2015	→
Editorial: structural plasticity induced by drugs of abuse.	Olive MF et al.	—	2015	→
Endogenous cholinergic neurotransmission contributes to behavioral sensitization to morphine.	Bajic D et al.	—	2015	→
Functional Connectome Analysis of Dopamine Neuron Glutamatergic Connections in Forebrain Regions.	Mingote S et al.	—	2015	→
GIRK Channel Plasticity and Implications for Drug Addiction.	Marron Fernandez de Velasco E et al.	—	2015	→
GIRK Channels: A Potential Link Between Learning and Addiction.	Tipps ME et al.	—	2015	→
Glutamate Receptors within the Mesolimbic Dopamine System Mediate Alcohol Relapse Behavior.	Eisenhardt M et al.	—	2015	→
[Hell after the pleasure: drug-induced negative symptoms involve lateral habenula].	Valentinova K et al.	—	2015	→
Homer 1a and mGluR5 phosphorylation in reward-sensitive metaplasticity: A hypothesis of neuronal selection and bidirectional synaptic plasticity.	Marton TM et al.	—	2015	→
Illuminating circuitry relevant to psychiatric disorders with optogenetics.	Steinberg EE et al.	—	2015	→
Impaired cognition after stimulation of P2Y1 receptors in the rat medial prefrontal cortex.	Koch H et al.	—	2015	→
Intrinsic membrane plasticity via increased persistent sodium conductance of cholinergic neurons in the rat laterodorsal tegmental nucleus contributes to cocaine-induced addictive behavior.	Kamii H et al.	—	2015	→
Intrinsic plasticity: an emerging player in addiction.	Kourrich S et al.	—	2015	→
Mechanisms of Action and Persistent Neuroplasticity by Drugs of Abuse.	Korpi ER et al.	—	2015	→
Mechanisms of Neuroplasticity and Ethanol's Effects on Plasticity in the Striatum and Bed Nucleus of the Stria Terminalis.	Lovinger DM et al.	—	2015	→
MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption.	Darcq E et al.	—	2015	→
Molecular mechanisms of synaptic remodeling in alcoholism.	Kyzar EJ et al.	—	2015	→
Morphine disinhibits glutamatergic input to VTA dopamine neurons and promotes dopamine neuron excitation.	Chen M et al.	—	2015	→
Morphine Regulated Synaptic Networks Revealed by Integrated Proteomics and Network Analysis.	Stockton SD et al.	—	2015	→
mRNA and microRNA analysis reveals modulation of biochemical pathways related to addiction in the ventral tegmental area of methamphetamine self-administering rats.	Bosch PJ et al.	—	2015	→
Multiple actions of a D₃ dopamine receptor agonist, PD128907, on GABAergic inhibitory transmission between medium spiny neurons in mouse nucleus accumbens shell.	Kohnomi S et al.	—	2015	→
Neural plasticity in hypocretin neurons: the basis of hypocretinergic regulation of physiological and behavioral functions in animals.	Gao XB et al.	—	2015	→
Nicotine and ethanol cooperate to enhance ventral tegmental area AMPA receptor function via α6-containing nicotinic receptors.	Engle SE et al.	—	2015	→
Nociception, Pain, Negative Moods, and Behavior Selection.	Baliki MN et al.	—	2015	→
Orexin/hypocretin role in reward: implications for opioid and other addictions.	Baimel C et al.	—	2015	→
Persistent Adaptations in Afferents to Ventral Tegmental Dopamine Neurons after Opiate Withdrawal.	Kaufling J et al.	—	2015	→
Phosphodiesterase regulation of alcohol drinking in rodents.	Logrip ML	—	2015	→
Post-transcriptional regulation of dopamine D1 receptor expression in caudate-putamen of cocaine-sensitized mice.	Tobón KE et al.	—	2015	→
PPARγ activation attenuates opioid consumption and modulates mesolimbic dopamine transmission.	de Guglielmo G et al.	—	2015	→
Prefrontal cortex gates acute morphine action on dopamine neurons in the ventral tegmental area.	Liu C et al.	—	2015	→
Regulation of the mesocorticolimbic and mesostriatal dopamine systems by α-melanocyte stimulating hormone and agouti-related protein.	Roseberry AG et al.	—	2015	→
Role of Dopamine Neurons in Reward and Aversion: A Synaptic Plasticity Perspective.	Pignatelli M et al.	—	2015	→
Role of the ventral tegmental area in methamphetamine extinction: AMPA receptor-mediated neuroplasticity.	Chen HT et al.	—	2015	→
Silent Synapses Speak Up: Updates of the Neural Rejuvenation Hypothesis of Drug Addiction.	Huang YH et al.	—	2015	→
Targeting glutamate uptake to treat alcohol use disorders.	Rao PS et al.	—	2015	→
The Brain on Drugs: From Reward to Addiction.	Volkow ND et al.	—	2015	→
The dark side of emotion: the addiction perspective.	Koob GF	—	2015	→
The ins and outs of the striatum: role in drug addiction.	Yager LM et al.	—	2015	→
The origin of glutamatergic synaptic inputs controls synaptic plasticity and its modulation by alcohol in mice nucleus accumbens.	Ji X et al.	—	2015	→
The pain of pain: challenges of animal behavior models.	Barrett JE	—	2015	→
The role of the GABA system in amphetamine-type stimulant use disorders.	Jiao D et al.	—	2015	→
The μ-opioid receptor: an electrophysiologist's perspective from the sharp end.	Henderson G	—	2015	→
Using c-fos to study neuronal ensembles in corticostriatal circuitry of addiction.	Cruz FC et al.	—	2015	→
Acid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity.	Kreple CJ et al.	—	2014	→
Addiction science: Uncovering neurobiological complexity.	Volkow ND et al.	—	2014	→
Amphetamine modulates excitatory neurotransmission through endocytosis of the glutamate transporter EAAT3 in dopamine neurons.	Underhill SM et al.	—	2014	→
A potential role for the paraventricular nucleus of the thalamus in mediating individual variation in Pavlovian conditioned responses.	Haight JL et al.	—	2014	→
Association of gamma-aminobutyric acid A receptor α2 gene (GABRA2) with alcohol use disorder.	Li D et al.	—	2014	→
Behavioral and neurochemical changes in mesostriatal dopaminergic regions of the rat after chronic administration of the cannabinoid receptor agonist WIN55,212-2.	Fanarioti E et al.	—	2014	→
Biological substrates of addiction.	Joffe ME et al.	—	2014	→
BK channels mediate dopamine inhibition of firing in a subpopulation of core nucleus accumbens medium spiny neurons.	Ji X et al.	—	2014	→
Blockade of D3 receptors by YQA14 inhibits cocaine's rewarding effects and relapse to drug-seeking behavior in rats.	Song R et al.	—	2014	→
Brain-derived neurotrophic factor mediates the suppression of alcohol self-administration by memantine.	Jeanblanc J et al.	—	2014	→
CC-chemokine ligand 2 facilitates conditioned place preference to methamphetamine through the activation of dopamine systems.	Wakida N et al.	—	2014	→
Cell-type specific increases in female hamster nucleus accumbens spine density following female sexual experience.	Staffend NA et al.	—	2014	→
Changes in the serum levels of brain-derived neurotrophic factor in adults with attention deficit hyperactivity disorder after treatment with atomoxetine.	Ramos-Quiroga JA et al.	—	2014	→
Cocaine exposure reorganizes cell type- and input-specific connectivity in the nucleus accumbens.	MacAskill AF et al.	—	2014	→
Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP.	Chiodi V et al.	—	2014	→
Contrasting forms of cocaine-evoked plasticity control components of relapse.	Pascoli V et al.	—	2014	→
CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects.	Bilbao A et al.	—	2014	→
Critical role of peripheral drug actions in experience-dependent changes in nucleus accumbens glutamate release induced by intravenous cocaine.	Wakabayashi KT et al.	—	2014	→
D1R/GluN1 complexes in the striatum integrate dopamine and glutamate signalling to control synaptic plasticity and cocaine-induced responses.	Cahill E et al.	—	2014	→
Deletion of SHATI/NAT8L increases dopamine D1 receptor on the cell surface in the nucleus accumbens, accelerating methamphetamine dependence.	Toriumi K et al.	—	2014	→
Dopamine D1 and D3 receptors mediate reconsolidation of cocaine memories in mouse models of drug self-administration.	Yan Y et al.	—	2014	→
Dopamine in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory.	Kramar CP et al.	—	2014	→
Dopamine neurons control striatal cholinergic neurons via regionally heterogeneous dopamine and glutamate signaling.	Chuhma N et al.	—	2014	→
Dopamine receptor activation increases HIV entry into primary human macrophages.	Gaskill PJ et al.	—	2014	→
Effectiveness of nicotinic agonists as desensitizers at presynaptic α4β2- and α4α5β2-nicotinic acetylcholine receptors.	Wageman CR et al.	—	2014	→
Effects of the abused inhalant toluene on the mesolimbic dopamine system.	Woodward JJ et al.	—	2014	→
Effects of thienorphine on synaptic structure and synaptophysin expression in the rat nucleus accumbens.	Yong Z et al.	—	2014	→
Effects of topiramate on ethanol-cocaine interactions and DNA methyltransferase gene expression in the rat prefrontal cortex.	Echeverry-Alzate V et al.	—	2014	→
Endocannabinoid signaling and food addiction.	D'Addario C et al.	—	2014	→
Ethanol attenuation of long-term depression in the nucleus accumbens can be overcome by activation of TRPV1 receptors.	Renteria R et al.	—	2014	→
Extinction of opiate reward reduces dendritic arborization and c-Fos expression in the nucleus accumbens core.	Leite-Morris KA et al.	—	2014	→
Extracellular signal-regulated protein kinases 1 and 2 activation by addictive drugs: a signal toward pathological adaptation.	Pascoli V et al.	—	2014	→
Functional deficiency of MHC class I enhances LTP and abolishes LTD in the nucleus accumbens of mice.	Edamura M et al.	—	2014	→
GABAA receptor drugs and neuronal plasticity in reward and aversion: focus on the ventral tegmental area.	Vashchinkina E et al.	—	2014	→
Glial modulators as potential treatments of psychostimulant abuse.	Beardsley PM et al.	—	2014	→
Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction.	van Huijstee AN et al.	—	2014	→
Illicit dopamine transients: reconciling actions of abused drugs.	Covey DP et al.	—	2014	→
Incubation of cocaine seeking following brief cocaine experience in mice is enhanced by mGluR1 blockade.	Halbout B et al.	—	2014	→
Influence of depressive symptoms on dopaminergic treatment of Parkinson's disease.	Hanganu A et al.	—	2014	→
Inhibition of PKC disrupts addiction-related memory.	Howell KK et al.	—	2014	→
Interference with AMPA receptor endocytosis: effects on behavioural and neurochemical correlates of amphetamine sensitization in male rats.	Choi FY et al.	—	2014	→
Learning induced epigenetic modifications in the ventral striatum are necessary for long-term memory.	Gaglio D et al.	—	2014	→
Live-cell imaging of receptors around postsynaptic membranes.	Tanaka H et al.	—	2014	→
MDMA impairs mitochondrial neuronal trafficking in a Tau- and Mitofusin2/Drp1-dependent manner.	Barbosa DJ et al.	—	2014	→
Mechanisms of transgenerational inheritance of addictive-like behaviors.	Vassoler FM et al.	—	2014	→
Methamphetamine-associated memory is regulated by a writer and an eraser of permissive histone methylation.	Aguilar-Valles A et al.	—	2014	→
Methamphetamine downregulates striatal glutamate receptors via diverse epigenetic mechanisms.	Jayanthi S et al.	—	2014	→
Molecular imaging in alcohol dependence.	Ravan S et al.	—	2014	→
Molecular profiling of neurons based on connectivity.	Ekstrand MI et al.	—	2014	→
Neural ECM in addiction, schizophrenia, and mood disorder.	Lubbers BR et al.	—	2014	→
Neurocircuitry of drug reward.	Ikemoto S et al.	—	2014	→
Neurosteroid Agonist at GABAA receptor induces persistent neuroplasticity in VTA dopamine neurons.	Vashchinkina E et al.	—	2014	→
New insights into the therapeutic potential of Girk channels.	Luján R et al.	—	2014	→
Nicotine self-administration induces CB1-dependent LTP in the bed nucleus of the stria terminalis.	Reisiger AR et al.	—	2014	→
Optogenetics reveals a role for accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization.	Song SS et al.	—	2014	→
Persistent pain facilitates response to morphine reward by downregulation of central amygdala GABAergic function.	Zhang Z et al.	—	2014	→
Pleiotrophin differentially regulates the rewarding and sedative effects of ethanol.	Vicente-Rodríguez M et al.	—	2014	→
Poststress block of kappa opioid receptors rescues long-term potentiation of inhibitory synapses and prevents reinstatement of cocaine seeking.	Polter AM et al.	—	2014	→
Prefrontal gamma-aminobutyric acid type A receptor insertion controls cue-induced relapse to nicotine seeking.	Lubbers BR et al.	—	2014	→
Prelimbic cortex and ventral tegmental area modulate synaptic plasticity differentially in nucleus accumbens during cocaine-reinstated drug seeking.	Shen HW et al.	—	2014	→
Psychobiology of cocaine addiction: Contribution of a multi-symptomatic animal model of loss of control.	Deroche-Gamonet V et al.	—	2014	→
Reward and aversion in a heterogeneous midbrain dopamine system.	Lammel S et al.	—	2014	→
Role of ALDH5A1 in methadone treatment.	Torrens M et al.	—	2014	→
Role of nucleus accumbens in neuropathic pain: linked multi-scale evidence in the rat transitioning to neuropathic pain.	Chang PC et al.	—	2014	→
Solving the mystery of memory.	Worley P et al.	—	2014	→
Sorting nexin 27 regulation of G protein-gated inwardly rectifying K⁺ channels attenuates in vivo cocaine response.	Munoz MB et al.	—	2014	→
Stress and VTA synapses: implications for addiction and depression.	Polter AM et al.	—	2014	→
Synaptic glutamate spillover due to impaired glutamate uptake mediates heroin relapse.	Shen HW et al.	—	2014	→
Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward.	Cui Y et al.	—	2014	→
The development and maintenance of drug addiction.	Wise RA et al.	—	2014	→
The role of D2-autoreceptors in regulating dopamine neuron activity and transmission.	Ford CP	—	2014	→
The role of D-serine as co-agonist of NMDA receptors in the nucleus accumbens: relevance to cocaine addiction.	D'Ascenzo M et al.	—	2014	→
The role of GABAB receptors in human reinforcement learning.	Ort A et al.	—	2014	→
VTA GABA neurons modulate specific learning behaviors through the control of dopamine and cholinergic systems.	Creed MC et al.	—	2014	→
Yin and Yang: unsilencing synapses to control cocaine seeking.	Kauer JA et al.	—	2014	→
A-kinase anchoring protein-calcineurin signaling in long-term depression of GABAergic synapses.	Dacher M et al.	—	2013	→
Alterations in ethanol-induced behaviors and consumption in knock-in mice expressing ethanol-resistant NMDA receptors.	den Hartog CR et al.	—	2013	→
Amphetamine-induced sensitization has little effect on multiple learning paradigms and fails to rescue mice with a striatal learning defect.	Eldred KC et al.	—	2013	→
A multistep general theory of transition to addiction.	Piazza PV et al.	—	2013	→
An indirect resilience to addiction.	Picciotto MR	—	2013	→
An investigation of interactions between hypocretin/orexin signaling and glutamate receptor surface expression in the rat nucleus accumbens under basal conditions and after cocaine exposure.	Plaza-Zabala A et al.	—	2013	→
An unusual suspect in cocaine addiction.	Huang YH et al.	—	2013	→
A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization.	Park JM et al.	—	2013	→
A single in vivo cocaine administration impairs 5-HT(1B) receptor-induced long-term depression in the nucleus accumbens.	Huang CC et al.	—	2013	→
A unique population of ventral tegmental area neurons inhibits the lateral habenula to promote reward.	Stamatakis AM et al.	—	2013	→
Binge ethanol-drinking potentiates corticotropin releasing factor R1 receptor activity in the ventral tegmental area.	Sparta DR et al.	—	2013	→
Biological contributions to addictions in adolescents and adults: prevention, treatment, and policy implications.	Potenza MN	—	2013	→
C57BL/6N mutation in cytoplasmic FMRP interacting protein 2 regulates cocaine response.	Kumar V et al.	—	2013	→
Cellular basis of memory for addiction.	Nestler EJ	—	2013	→
Closing the gate in the limbic striatum: prefrontal suppression of hippocampal and thalamic inputs.	Calhoon GG et al.	—	2013	→
Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement.	Tolu S et al.	—	2013	→
Cocaine disinhibits dopamine neurons by potentiation of GABA transmission in the ventral tegmental area.	Bocklisch C et al.	—	2013	→
Cocaine-evoked synaptic plasticity of excitatory transmission in the ventral tegmental area.	Lüscher C	—	2013	→
Cocaine exposure enhances excitatory synaptic drive to cholinergic neurons in the laterodorsal tegmental nucleus.	Kurosawa R et al.	—	2013	→
Cocaine sensitization increases I h current channel subunit 2 (HCN₂) protein expression in structures of the mesocorticolimbic system.	Santos-Vera B et al.	—	2013	→
Corticotropin-releasing factor infusion into nucleus incertus suppresses medial prefrontal cortical activity and hippocampo-medial prefrontal cortical long-term potentiation.	Farooq U et al.	—	2013	→
Differential role of ventral tegmental area acetylcholine and N-methyl-D-aspartate receptors in cocaine-seeking.	Solecki W et al.	—	2013	→
Dopamine D3 receptors regulate reconsolidation of cocaine memory.	Yan Y et al.	—	2013	→
Dopaminergic neurons encode a distributed, asymmetric representation of temperature in Drosophila.	Tomchik SM	—	2013	→
Dopamine signaling in reward-related behaviors.	Baik JH	—	2013	→
Drug-evoked synaptic plasticity causing addictive behavior.	Lüscher C	—	2013	→
ELK1 transcription factor linked to dysregulated striatal mu opioid receptor signaling network and OPRM1 polymorphism in human heroin abusers.	Daws SE et al.	—	2013	→
Emerging roles of metaplasticity in behaviour and disease.	Hulme SR et al.	—	2013	→
Epigenetics and psychostimulant addiction.	Schmidt HD et al.	—	2013	→
Expression of cocaine-evoked synaptic plasticity by GluN3A-containing NMDA receptors.	Yuan T et al.	—	2013	→
∆FosB differentially modulates nucleus accumbens direct and indirect pathway function.	Grueter BA et al.	—	2013	→
Hypothalamic neurotensin projections promote reward by enhancing glutamate transmission in the VTA.	Kempadoo KA et al.	—	2013	→
Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids.	Labouèbe G et al.	—	2013	→
Kappa opioid receptors regulate stress-induced cocaine seeking and synaptic plasticity.	Graziane NM et al.	—	2013	→
Locomotor sensitization to ethanol impairs NMDA receptor-dependent synaptic plasticity in the nucleus accumbens and increases ethanol self-administration.	Abrahao KP et al.	—	2013	→
Loss of D2 dopamine receptor function modulates cocaine-induced glutamatergic synaptic potentiation in the ventral tegmental area.	Madhavan A et al.	—	2013	→
Medial prefrontal cortex inversely regulates toluene-induced changes in markers of synaptic plasticity of mesolimbic dopamine neurons.	Beckley JT et al.	—	2013	→
Molecular and cellular mechanisms of dopamine-mediated behavioral plasticity in the striatum.	Cerovic M et al.	—	2013	→
Molecular, cellular, and structural mechanisms of cocaine addiction: a key role for microRNAs.	Jonkman S et al.	—	2013	→
Neuropeptide y gates a stress-induced, long-lasting plasticity in the sympathetic nervous system.	Wang Q et al.	—	2013	→
New technologies for examining the role of neuronal ensembles in drug addiction and fear.	Cruz FC et al.	—	2013	→
Nicotine addiction reduces the large-conductance Ca(2+)-activated potassium channels expression in the nucleus accumbens.	Ma L et al.	—	2013	→
Novel drug-regulated transcriptional networks in brain reveal pharmacological properties of psychotropic drugs.	Korostynski M et al.	—	2013	→
Novelty-seeking behaviors and the escalation of alcohol drinking after abstinence in mice are controlled by metabotropic glutamate receptor 5 on neurons expressing dopamine d1 receptors.	Parkitna JR et al.	—	2013	→
Nuclear calcium signalling in the regulation of brain function.	Bading H	—	2013	→
Opiate dependence induces network state shifts in the limbic system.	Dejean C et al.	—	2013	→
Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors.	Nieh EH et al.	—	2013	→
Optogenetic evidence that pallidal projections, not nigral projections, from the nucleus accumbens core are necessary for reinstating cocaine seeking.	Stefanik MT et al.	—	2013	→
Optogenetic interrogations of the neural circuits underlying addiction.	Britt JP et al.	—	2013	→
Orexin receptors: multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders.	Xu TR et al.	—	2013	→
Parceling human accumbens into putative core and shell dissociates encoding of values for reward and pain.	Baliki MN et al.	—	2013	→
Possible contributions of a novel form of synaptic plasticity in Aplysia to reward, memory, and their dysfunctions in mammalian brain.	Hawkins RD	—	2013	→
Potential substrates for nicotine and alcohol interactions: a focus on the mesocorticolimbic dopamine system.	Doyon WM et al.	—	2013	→
Prefrontal synaptic markers of cocaine addiction-like behavior in rats.	Kasanetz F et al.	—	2013	→
Recent advances in quantitative neuroproteomics.	Craft GE et al.	—	2013	→
Reduced D-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity.	Curcio L et al.	—	2013	→
Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiation.	Gipson CD et al.	—	2013	→
Repeated cocaine exposure increases fast-spiking interneuron excitability in the rat medial prefrontal cortex.	Campanac E et al.	—	2013	→
Role of dopamine D2 receptors in plasticity of stress-induced addictive behaviours.	Sim HR et al.	—	2013	→
Role of the major glutamate transporter GLT1 in nucleus accumbens core versus shell in cue-induced cocaine-seeking behavior.	Fischer KD et al.	—	2013	→
Salsolinol modulation of dopamine neurons.	Xie G et al.	—	2013	→
Spike timing-dependent plasticity at GABAergic synapses in the ventral tegmental area.	Kodangattil JN et al.	—	2013	→
Striatocortical pathway dysfunction in addiction and obesity: differences and similarities.	Tomasi D et al.	—	2013	→
Sucrose ingestion induces rapid AMPA receptor trafficking.	Tukey DS et al.	—	2013	→
Synaptic targets of Δ9-tetrahydrocannabinol in the central nervous system.	Hoffman AF et al.	—	2013	→
The effects of abused drugs on adolescent development of corticolimbic circuitry and behavior.	Gulley JM et al.	—	2013	→
The neurobiology of modafinil as an enhancer of cognitive performance and a potential treatment for substance use disorders.	Mereu M et al.	—	2013	→
Transforming growth factor beta receptor 1 is increased following abstinence from cocaine self-administration, but not cocaine sensitization.	Gancarz-Kausch AM et al.	—	2013	→
Using metabotropic glutamate receptors to modulate cocaine's synaptic and behavioral effects: mGluR1 finds a niche.	Loweth JA et al.	—	2013	→
Ventral tegmental area cannabinoid type-1 receptors control voluntary exercise performance.	Dubreucq S et al.	—	2013	→
α4α6β2* nicotinic acetylcholine receptor activation on ventral tegmental area dopamine neurons is sufficient to stimulate a depolarizing conductance and enhance surface AMPA receptor function.	Engle SE et al.	—	2013	→
Activation of VTA GABA neurons disrupts reward consumption.	van Zessen R et al.	—	2012	→
Addictive drugs and plasticity of glutamatergic synapses on dopaminergic neurons: what have we learned from genetic mouse models?	Rodriguez Parkitna J et al.	—	2012	→
An emerging role for the Mammalian target of rapamycin in "pathological" protein translation: relevance to cocaine addiction.	Dayas CV et al.	—	2012	→
A role for kalirin in the response of rat medium spiny neurons to cocaine.	Ma XM et al.	—	2012	→
BACE1 elevation is associated with aberrant limbic axonal sprouting in epileptic CD1 mice.	Yan XX et al.	—	2012	→
Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how, and why?	Wolf ME et al.	—	2012	→
Chronic atomoxetine treatment during adolescence decreases impulsive choice, but not impulsive action, in adult rats and alters markers of synaptic plasticity in the orbitofrontal cortex.	Sun H et al.	—	2012	→
Cocaine and nicotine research illustrates a range of hypocretin mechanisms in addiction.	Baimel C et al.	—	2012	→
Cocaine evokes projection-specific synaptic plasticity of lateral habenula neurons.	Maroteaux M et al.	—	2012	→
Cocaine-induced adaptations in metabotropic inhibitory signaling in the mesocorticolimbic system.	Hearing MC et al.	—	2012	→
Cocaine reverses the naltrexone-induced reduction in operant ethanol self-administration: the effects on immediate-early gene expression in the rat prefrontal cortex.	Echeverry-Alzate V et al.	—	2012	→
Deep brain stimulation for psychiatric disease: contributions and validity of animal models.	Hamani C et al.	—	2012	→
Dopamine is required for learning and forgetting in Drosophila.	Berry JA et al.	—	2012	→
Drug-evoked plasticity: do addictive drugs reopen a critical period of postnatal synaptic development?	Bellone C et al.	—	2012	→
Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior.	Wang J et al.	—	2012	→
Food and drug reward: overlapping circuits in human obesity and addiction.	Volkow ND et al.	—	2012	→
GABA neurons in the ventral tegmental area responding to peripheral sensory input.	Liu CL et al.	—	2012	→
GABA neurons of the VTA drive conditioned place aversion.	Tan KR et al.	—	2012	→
GABA site agonist gaboxadol induces addiction-predicting persistent changes in ventral tegmental area dopamine neurons but is not rewarding in mice or baboons.	Vashchinkina E et al.	—	2012	→
Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.	Klug JR et al.	—	2012	→
In medication-overuse headache, fMRI shows long-lasting dysfunction in midbrain areas.	Ferraro S et al.	—	2012	→
Insights to drug addiction derived from ultrastructural views of the mesocorticolimbic system.	Morales M et al.	—	2012	→
Integrating synaptic plasticity and striatal circuit function in addiction.	Grueter BA et al.	—	2012	→
Mechanisms of psychostimulant-induced structural plasticity.	Golden SA et al.	—	2012	→
Memory, plasticity and sleep - A role for calcium permeable AMPA receptors?	Shepherd JD	—	2012	→
Methamphetamine causes differential alterations in gene expression and patterns of histone acetylation/hypoacetylation in the rat nucleus accumbens.	Martin TA et al.	—	2012	→
Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA.	Padgett CL et al.	—	2012	→
mGluR-Dependent Synaptic Plasticity in Drug-Seeking.	Bellone C et al.	—	2012	→
mGlu receptors and drug addiction.	Cleva RM et al.	—	2012	→
MicroRNAs in learning, memory, and neurological diseases.	Wang W et al.	—	2012	→
Neuron-type-specific signals for reward and punishment in the ventral tegmental area.	Cohen JY et al.	—	2012	→
Neuroplasticity in addiction: cellular and transcriptional perspectives.	Madsen HB et al.	—	2012	→
NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD).	Lüscher C et al.	—	2012	→
Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, ion channels and transcranial magnetic stimulation.	Addolorato G et al.	—	2012	→
Opiate-induced molecular and cellular plasticity of ventral tegmental area and locus coeruleus catecholamine neurons.	Mazei-Robison MS et al.	—	2012	→
Optogenetic investigation of neural circuits underlying brain disease in animal models.	Tye KM et al.	—	2012	→
[Optogenetic reversal of cocaine-evoked synaptic potentiation normalizes behavioural sensitization].	Lüscher C et al.	—	2012	→
Protracted withdrawal from cocaine self-administration flips the switch on 5-HT(1B) receptor modulation of cocaine abuse-related behaviors.	Pentkowski NS et al.	—	2012	→
Putting desire on a budget: dopamine and energy expenditure, reconciling reward and resources.	Beeler JA et al.	—	2012	→
Scaffold protein Homer 1: implications for neurological diseases.	Luo P et al.	—	2012	→
Signaling in striatal neurons: the phosphoproteins of reward, addiction, and dyskinesia.	Girault JA	—	2012	→
Stress and addiction: contribution of the corticotropin releasing factor (CRF) system in neuroplasticity.	Haass-Koffler CL et al.	—	2012	→
Synaptic and behavioral profile of multiple glutamatergic inputs to the nucleus accumbens.	Britt JP et al.	—	2012	→
The antibiotic minocycline prevents methamphetamine-induced rewarding effects in mice.	Fujita Y et al.	—	2012	→
The Hepatocyte Growth Factor/c-Met Antagonist, Divalinal-Angiotensin IV, Blocks the Acquisition of Methamphetamine Dependent Conditioned Place Preference in Rats.	Wright JW et al.	—	2012	→
The neurobiology of addiction-like behaviors.	Van Bockstaele EJ	—	2012	→
Transgenic expression of ZBP1 in neurons suppresses cocaine-associated conditioning.	Lapidus KA et al.	—	2012	→
Upregulation of nerve growth factor in central amygdala increases sensitivity to opioid reward.	Bie B et al.	—	2012	→
Virogenetic and optogenetic mechanisms to define potential therapeutic targets in psychiatric disorders.	Han MH et al.	—	2012	→
Cav1.2 L-type Ca²⁺ channels mediate cocaine-induced GluA1 trafficking in the nucleus accumbens, a long-term adaptation dependent on ventral tegmental area Ca(v)1.3 channels.	Schierberl K et al.	—	2011	→
DARPP-32, Jack of All Trades… Master of Which?	Yger M et al.	—	2011	→
Dynamic regulation of midbrain dopamine neuron activity: intrinsic, synaptic, and plasticity mechanisms.	Morikawa H et al.	—	2011	→
Endocannabinoid-mediated synaptic plasticity and addiction-related behavior.	Sidhpura N et al.	—	2011	→
Enhanced sucrose and cocaine self-administration and cue-induced drug seeking after loss of VGLUT2 in midbrain dopamine neurons in mice.	Alsiö J et al.	—	2011	→
Genes and pathways co-associated with the exposure to multiple drugs of abuse, including alcohol, amphetamine/methamphetamine, cocaine, marijuana, morphine, and/or nicotine: a review of proteomics analyses.	Wang J et al.	—	2011	→
L-type voltage-dependent calcium channels facilitate acetylation of histone H3 through PKCγ phosphorylation in mice with methamphetamine-induced place preference.	Shibasaki M et al.	—	2011	→
MicroRNAs in addiction: adaptation's middlemen?	Li MD et al.	—	2011	→
Multiple personalities in the ventral tegmental area.	Borgkvist A et al.	—	2011	→
Reversal of cocaine-evoked synaptic potentiation resets drug-induced adaptive behaviour.	Pascoli V et al.	—	2011	→
Searching for presynaptic NMDA receptors in the nucleus accumbens.	Huang YH et al.	—	2011	→
Src family kinases: modulators of neurotransmitter receptor function and behavior.	Ohnishi H et al.	—	2011	→