Repeated cocaine exposure in vivo facilitates LTP induction in midbrain dopamine neurons.
paper
Cited
Public
Unavailable
- Authors
- Liu, Qing-song; Pu, Lu; Poo, Mu-ming
- Year
- 2005
- Journal
- Nature
- PMID
- 16222299
- DOI
- 10.1038/nature04050
- PMCID
- PMC1457101
Drugs of abuse are known to cause persistent modification of neural circuits, leading to addictive behaviours. Changes in synaptic plasticity in dopamine neurons of the ventral tegmental area (VTA) may contribute to circuit modification induced by many drugs of abuse, including cocaine. Here we report that, following repeated exposure to cocaine in vivo, excitatory synapses to rat VTA dopamine neurons become highly susceptible to the induction of long-term potentiation (LTP) by correlated pre- and postsynaptic activity. This facilitated LTP induction is caused by cocaine-induced reduction of GABA(A) (gamma-aminobutyric acid) receptor-mediated inhibition of these dopamine neurons. In midbrain slices from rats treated with saline or a single dose of cocaine, LTP could not be induced in VTA dopamine neurons unless GABA-mediated inhibition was reduced by bicuculline or picrotoxin. However, LTP became readily inducible in slices from rats treated repeatedly with cocaine; this LTP induction was prevented by enhancing GABA-mediated inhibition using diazepam. Furthermore, repeated cocaine exposure reduced the amplitude of GABA-mediated synaptic currents and increased the probability of spike initiation in VTA dopamine neurons. This cocaine-induced enhancement of synaptic plasticity in the VTA may be important for the formation of drug-associated memory.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Alzheimer's Pathology Enhances Excitatory Synaptic Input and Integration in VTA Dopamine Neurons. | Blankenship HE et al. | β | 2026 | β |
| Cannabinoid-based Pharmacology for the Management of Substance Use Disorders. | LujΓ‘n MΓ et al. | β | 2026 | β |
| Social reward outcompetes drug seeking dopaminergic ensembles to prevent relapse. | Zheng W et al. | β | 2026 | β |
| Brain-Behavior Relationships: Neural Mechanisms of Impulsivity and Compulsivity in Neuropsychiatric Disorders. | Maerean N et al. | β | 2025 | β |
| Erasing "bad memories": reversing aberrant synaptic plasticity as therapy for neurological and psychiatric disorders. | Shi Z et al. | β | 2025 | β |
| EGCG attenuates METH self-administration and reinstatement of METH seeking in mice. | Si Z et al. | β | 2023 | β |
| Endocannabinoid-dependent decrease of GABAergic transmission on dopaminergic neurons is associated with susceptibility to cocaine stimulant effects in pre-adolescent male MAOA hypomorphic mice exposed to early life stress. | Serra V et al. | β | 2023 | β |
| Endocannabinoids at the synapse and beyond: implications for neuropsychiatric disease pathophysiology and treatment. | Scheyer A et al. | β | 2023 | β |
| Ethanol blocks a novel form of iLTD, but not iLTP of inhibitory inputs to VTA GABA neurons. | Nufer TM et al. | β | 2023 | β |
| Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA. | Yang J et al. | β | 2023 | β |
| Addiction-induced plasticity in underlying neural circuits. | Kourosh-Arami M et al. | β | 2022 | β |
| A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference. | Beiser T et al. | β | 2022 | β |
| Common and gender-specific associations with cocaine use on gray matter volume: Data from the ENIGMA addiction working group. | Rabin RA et al. | β | 2022 | β |
| Contingent Amygdala Inputs Trigger Heterosynaptic LTP at Hippocampus-To-Accumbens Synapses. | Yu J et al. | β | 2022 | β |
| Effects of isoflurane anesthesia on addictive behaviors in rats. | Yoon SS et al. | β | 2022 | β |
| 3D Synaptic Organization of the Rat CA1 and Alterations Induced by Cocaine Self-Administration. | Blazquez-Llorca L et al. | β | 2021 | β |
| Acute cocaine exposure occludes long-term depression in ventral tegmental area GABA neurons. | Friend LN et al. | β | 2021 | β |
| Drug addiction: from bench to bedside. | Cheron J et al. | β | 2021 | β |
| Exercise craving potentiates excitatory inputs to ventral tegmental area dopaminergic neurons. | Medrano MC et al. | β | 2021 | β |
| Genetic Modulation of Initial Sensitivity to Ξ9-Tetrahydrocannabinol (THC) Among the BXD Family of Mice. | Parks C et al. | β | 2021 | β |
| Ibudilast attenuates cocaine self-administration and prime- and cue-induced reinstatement of cocaine seeking in rats. | Mu L et al. | β | 2021 | β |
| Microglia depletion by PLX3397 has no effect on cocaine-induced behavioral sensitization in male mice. | Wu CM et al. | β | 2021 | β |
| Opioid-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area Dopamine Neurons. | Doyle MA et al. | β | 2021 | β |
| What Have We Learned (or Expect to) From Analysis of Murine Genetic Models Related to Substance Use Disorders? | Peltz G et al. | β | 2021 | β |
| Activity-Dependent Epigenetic Remodeling in Cocaine Use Disorder. | LΓ³pez AJ et al. | β | 2020 | β |
| Alpha-1 Adrenergic Receptors Modulate Glutamate and GABA Neurotransmission onto Ventral Tegmental Dopamine Neurons during Cocaine Sensitization. | Velasquez-Martinez MC et al. | β | 2020 | β |
| Anatomic resolution of neurotransmitter-specific projections to the VTA reveals diversity of GABAergic inputs. | Soden ME et al. | β | 2020 | β |
| Atlastin-1 modulates seizure activity and neuronal excitability. | Lu X et al. | β | 2020 | β |
| Conditional Single Vector CRISPR/SaCas9 Viruses for Efficient Mutagenesis in the Adult Mouse Nervous System. | Hunker AC et al. | β | 2020 | β |
| Impaired hypocretin/orexin system alters responses to salient stimuli in obese male mice. | Tan Y et al. | β | 2020 | β |
| Lights on Endocannabinoid-Mediated Synaptic Potentiation. | Piette C et al. | β | 2020 | β |
| Prolonged Use of NMDAR Antagonist Develops Analgesic Tolerance in Neuropathic Pain via Nitric Oxide Reduction-Induced GABAergic Disinhibition. | Li J et al. | β | 2020 | β |
| Stress-induced plasticity and functioning of ventral tegmental dopamine neurons. | Douma EH et al. | β | 2020 | β |
| Transient appearance of Ca<sup>2+</sup> -permeable AMPA receptors is crucial for the production of repetitive LTP-induced synaptic enhancement (RISE) in cultured hippocampal slices. | Tominaga-Yoshino K et al. | β | 2020 | β |
| Deep learning in spiking neural networks. | Tavanaei A et al. | β | 2019 | β |
| GABA<sub>B</sub> receptor positive allosteric modulators with different efficacies affect neuroadaptation to and self-administration of alcohol and cocaine. | de Miguel E et al. | β | 2019 | β |
| Mechanisms of cannabinoid CB<sub>2</sub> receptor-mediated reduction of dopamine neuronal excitability in mouse ventral tegmental area. | Ma Z et al. | β | 2019 | β |
| Neuronal excitatory amino acid transporter EAAT3: Emerging functions in health and disease. | Underhill SM et al. | β | 2019 | β |
| On the Modulatory Roles of Neuregulins/ErbB Signaling on Synaptic Plasticity. | Ledonne A et al. | β | 2019 | β |
| Protein and surface expression of HCN2 and HCN4 subunits in mesocorticolimbic areas after cocaine sensitization. | Santos-Vera B et al. | β | 2019 | β |
| Protrudin modulates seizure activity through GABA<sub>A</sub> receptor regulation. | Lu X et al. | β | 2019 | β |
| Synaptic and intrinsic plasticity in the ventral tegmental area after chronic cocaine. | Francis TC et al. | β | 2019 | β |
| Synaptic Plasticity at Inhibitory Synapses in the Ventral Tegmental Area Depends upon Stimulation Site. | St Laurent R et al. | β | 2019 | β |
| Acupuncture reduces relapse to cocaine-seeking behavior via activation of GABA neurons in the ventral tegmental area. | Jin W et al. | β | 2018 | β |
| aPKC-Mediated Persistent Increase in AMPA/NMDA Ratio in the VTA Participates in the Neuroadaptive Signal Necessary to Induce NAc Synaptic Plasticity After Cocaine Administration. | Vaquer-Alicea ADC et al. | β | 2018 | β |
| c-Fos marking of identified midbrain neurons coactive after nicotine administration in-vivo. | Baur K et al. | β | 2018 | β |
| Cocaine-induced locomotor sensitization associates with slow oscillatory firing of neurons in the ventral tegmental area. | Liu CL et al. | β | 2018 | β |
| General differential Hebbian learning: Capturing temporal relations between events in neural networks and the brain. | Zappacosta S et al. | β | 2018 | β |
| Inactivation of NMDA Receptors in the Ventral Tegmental Area during Cocaine Self-Administration Prevents GluA1 Upregulation but with Paradoxical Increases in Cocaine-Seeking Behavior. | Guzman D et al. | β | 2018 | β |
| Long-Term Plasticity of Neurotransmitter Release: Emerging Mechanisms and Contributions to Brain Function and Disease. | Monday HR et al. | β | 2018 | β |
| Persistent effects of obesity: a neuroplasticity hypothesis. | Matikainen-Ankney BA et al. | β | 2018 | β |
| SPARC and GluA1-Containing AMPA Receptors Promote Neuronal Health Following CNS Injury. | Jones EV et al. | β | 2018 | β |
| Synaptic function and plasticity in identified inhibitory inputs onto VTA dopamine neurons. | Polter AM et al. | β | 2018 | β |
| VTA mTOR Signaling Regulates Dopamine Dynamics, Cocaine-Induced Synaptic Alterations, and Reward. | Liu X et al. | β | 2018 | β |
| A single dose of cocaine potentiates glutamatergic synaptic transmission onto locus coeruleus neurons. | Zhu F et al. | β | 2017 | β |
| Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning. | Mills F et al. | β | 2017 | β |
| Cocaine Promotes Coincidence Detection and Lowers Induction Threshold during Hebbian Associative Synaptic Potentiation in Prefrontal Cortex. | Ruan H et al. | β | 2017 | β |
| Cocaine self-administration induces changes in synaptic transmission and plasticity in ventral hippocampus. | Keralapurath MM et al. | β | 2017 | β |
| Endocannabinoid modulation of dopamine neurotransmission. | Covey DP et al. | β | 2017 | β |
| Opiates and Plasticity in the Ventral Tegmental Area. | Langlois LD et al. | β | 2017 | β |
| PDE4 Inhibition Restores the Balance Between Excitation and Inhibition in VTA Dopamine Neurons Disrupted by Repeated In Vivo Cocaine Exposure. | Liu X et al. | β | 2017 | β |
| Resveratrol modulates cocaine-induced inhibitory synaptic plasticity in VTA dopamine neurons by inhibiting phosphodiesterases (PDEs). | Li Y et al. | β | 2017 | β |
| Roundabout receptor 2 maintains inhibitory control of the adult midbrain. | Gore BB et al. | β | 2017 | β |
| The Epac-Phospholipase CΞ΅ Pathway Regulates Endocannabinoid Signaling and Cocaine-Induced Disinhibition of Ventral Tegmental Area Dopamine Neurons. | Tong J et al. | β | 2017 | β |
| A Role for the GIRK3 Subunit in Methamphetamine-Induced Attenuation of GABAB Receptor-Activated GIRK Currents in VTA Dopamine Neurons. | Munoz MB et al. | β | 2016 | β |
| Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure. | Buczynski MW et al. | β | 2016 | β |
| Diversity of Dopaminergic Neural Circuits in Response to Drug Exposure. | Juarez B et al. | β | 2016 | β |
| Drug-Induced Alterations of Endocannabinoid-Mediated Plasticity in Brain Reward Regions. | Zlebnik NE et al. | β | 2016 | β |
| Epac Signaling Is Required for Cocaine-Induced Change in AMPA Receptor Subunit Composition in the Ventral Tegmental Area. | Liu X et al. | β | 2016 | β |
| [The baclofene saga and the paradigm shift in alcohol addiction treatment]. | Journiac K et al. | β | 2016 | β |
| The Emergence of a Circuit Model for Addiction. | LΓΌscher C | β | 2016 | β |
| Ventral Tegmental Area Afferents and Drug-Dependent Behaviors. | Oliva I et al. | β | 2016 | β |
| VTA dopamine neuron plasticity - the unusual suspects. | Xin W et al. | β | 2016 | β |
| BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons. | Zhong P et al. | β | 2015 | β |
| Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity. | Zhang Z et al. | β | 2015 | β |
| Cannabinoid modulation of drug reward and the implications of marijuana legalization. | Covey DP et al. | β | 2015 | β |
| CREB-BDNF pathway influences alcohol cue-elicited activation in drinkers. | Chen J et al. | β | 2015 | β |
| Dopamine Prediction Errors in Reward Learning and Addiction: From Theory to Neural Circuitry. | Keiflin R et al. | β | 2015 | β |
| Endocannabinoid signalling in reward and addiction. | Parsons LH et al. | β | 2015 | β |
| GluN2B-containing NMDA receptors blockade rescues bidirectional synaptic plasticity in the bed nucleus of the stria terminalis of cocaine self-administering rats. | deBacker J et al. | β | 2015 | β |
| Mechanism of morphine addiction by inhibiting the soluble Guanylate Cyclase-Nitric Oxide (sGC-NO) pathway. | Bhatt K et al. | β | 2015 | β |
| Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex. | Tang B et al. | β | 2015 | β |
| Multiple faces of BDNF in cocaine addiction. | Li X et al. | β | 2015 | β |
| Neuronal Reward and Decision Signals: From Theories to Data. | Schultz W | β | 2015 | β |
| Social interaction and cocaine conditioning in mice increase spontaneous spike frequency in the nucleus accumbens or septal nuclei as revealed by multielectrode array recordings. | Kummer KK et al. | β | 2015 | β |
| The effect of CA1 dopaminergic system in harmaline-induced amnesia. | Nasehi M et al. | β | 2015 | β |
| CaMKII activity in the ventral tegmental area gates cocaine-induced synaptic plasticity in the nucleus accumbens. | Liu X et al. | β | 2014 | β |
| Cannabinoid type-1 receptor ligands, alone or in combination with cocaine, affect vigilance-related behaviors of marmoset monkeys. | Cagni P et al. | β | 2014 | β |
| Cocaine facilitates protein synthesis-dependent LTP: the role of metabotropic glutamate receptors. | Fole A et al. | β | 2014 | β |
| Dopamine-enabled anti-Hebbian timing-dependent plasticity in prefrontal circuitry. | Ruan H et al. | β | 2014 | β |
| Glutamatergic synaptic plasticity in the mesocorticolimbic system in addiction. | van Huijstee AN et al. | β | 2014 | β |
| Microinfusion of bupropion inhibits putative GABAergic neuronal activity of the ventral tegmental area. | Amirabadi S et al. | β | 2014 | β |
| Neurotrophins in the ventral tegmental area: Role in social stress, mood disorders and drug abuse. | Nikulina EM et al. | β | 2014 | β |
| Reward and aversion in a heterogeneous midbrain dopamine system. | Lammel S et al. | β | 2014 | β |
| Single-cell genetic expression of mutant GABAA receptors causing Human genetic epilepsy alters dendritic spine and GABAergic bouton formation in a mutation-specific manner. | Lachance-Touchette P et al. | β | 2014 | β |
| Sorting nexin 27 regulation of G protein-gated inwardly rectifying KβΊ channels attenuates in vivo cocaine response. | Munoz MB et al. | β | 2014 | β |
| Changes in plasticity across the lifespan: cause of disease and target for intervention. | Oberman L et al. | β | 2013 | β |
| Cocaine disinhibits dopamine neurons by potentiation of GABA transmission in the ventral tegmental area. | Bocklisch C et al. | β | 2013 | β |
| Effects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome. | Eipper-Mains JE et al. | β | 2013 | β |
| Metabotropic glutamate receptor I (mGluR1) antagonism impairs cocaine-induced conditioned place preference via inhibition of protein synthesis. | Yu F et al. | β | 2013 | β |
| New insights on neurobiological mechanisms underlying alcohol addiction. | Cui C et al. | β | 2013 | β |
| Repeated in vivo exposure of cocaine induces long-lasting synaptic plasticity in hypocretin/orexin-producing neurons in the lateral hypothalamus in mice. | Rao Y et al. | β | 2013 | β |
| Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats. | Gao J et al. | β | 2013 | β |
| Spike timing-dependent plasticity at GABAergic synapses in the ventral tegmental area. | Kodangattil JN et al. | β | 2013 | β |
| Addictive drugs and plasticity of glutamatergic synapses on dopaminergic neurons: what have we learned from genetic mouse models? | Rodriguez Parkitna J et al. | β | 2012 | β |
| AgRP neurons regulate development of dopamine neuronal plasticity and nonfood-associated behaviors. | Dietrich MO et al. | β | 2012 | β |
| Calcium-permeable AMPA receptors in the VTA and nucleus accumbens after cocaine exposure: when, how, and why? | Wolf ME et al. | β | 2012 | β |
| Detection of bursts and pauses in spike trains. | Ko D et al. | β | 2012 | β |
| Methamphetamine-evoked depression of GABA(B) receptor signaling in GABA neurons of the VTA. | Padgett CL et al. | β | 2012 | β |
| Modifications of the input currents on VTA dopamine neurons following acute versus chronic cocaine exposure. | Michaeli A et al. | β | 2012 | β |
| Modulation by cocaine of dopamine receptors through miRNA-133b in zebrafish embryos. | Barreto-Valer K et al. | β | 2012 | β |
| Neuroplasticity in addiction: cellular and transcriptional perspectives. | Madsen HB et al. | β | 2012 | β |
| Neurotensin inhibits glutamate-mediated synaptic inputs onto ventral tegmental area dopamine neurons through the release of the endocannabinoid 2-AG. | Kortleven C et al. | β | 2012 | β |
| Organization of GABAergic synaptic circuits in the rat ventral tegmental area. | Ciccarelli A et al. | β | 2012 | β |
| Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference. | Zhong P et al. | β | 2012 | β |
| The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. | Derringer J et al. | β | 2012 | β |
| Virogenetic and optogenetic mechanisms to define potential therapeutic targets in psychiatric disorders. | Han MH et al. | β | 2012 | β |
| Addiction and brain reward and antireward pathways. | Gardner EL | β | 2011 | β |
| Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice. | Pan B et al. | β | 2011 | β |
| Cocaine-induced metaplasticity in the nucleus accumbens: silent synapse and beyond. | Lee BR et al. | β | 2011 | β |
| Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala. | Krishnan B et al. | β | 2011 | β |
| Dopamine-related drugs act presynaptically to potentiate GABA(A) receptor currents in VTA dopamine neurons. | Michaeli A et al. | β | 2011 | β |
| Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling. | LΓΌscher C et al. | β | 2011 | β |
| Dynamic regulation of midbrain dopamine neuron activity: intrinsic, synaptic, and plasticity mechanisms. | Morikawa H et al. | β | 2011 | β |
| Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors. | Serrano A et al. | β | 2011 | β |
| Endocannabinoid-mediated synaptic plasticity and addiction-related behavior. | Sidhpura N et al. | β | 2011 | β |
| Erk1/2 mediates leptin receptor signaling in the ventral tegmental area. | Trinko R et al. | β | 2011 | β |
| Exposure of nicotine to ventral tegmental area slices induces glutamatergic synaptic plasticity on dopamine neurons. | Jin Y et al. | β | 2011 | β |
| Extracellular signal-regulated kinase signaling in the ventral tegmental area mediates cocaine-induced synaptic plasticity and rewarding effects. | Pan B et al. | β | 2011 | β |
| Hooked on benzodiazepines: GABAA receptor subtypes and addiction. | Tan KR et al. | β | 2011 | β |
| Neuroscience in China: Growth factor. | Cyranoski D | β | 2011 | β |
| Opiates and plasticity. | Dacher M et al. | β | 2011 | β |
| Polyrhythms of the brain. | Battaglia FP et al. | β | 2011 | β |
| Prenatal cocaine exposure enhances long-term potentiation induction in rat medial prefrontal cortex. | Huang CC et al. | β | 2011 | β |
| Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. | Lammel S et al. | β | 2011 | β |
| Reduced locomotor responses to cocaine in ghrelin-deficient mice. | Abizaid A et al. | β | 2011 | β |
| Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine. | Choi KH et al. | β | 2011 | β |
| Striatal signal transduction and drug addiction. | Philibin SD et al. | β | 2011 | β |
| Synaptic plasticity and addiction: learning mechanisms gone awry. | Mameli M et al. | β | 2011 | β |
| The endocannabinoid 2-arachidonoylglycerol inhibits long-term potentiation of glutamatergic synapses onto ventral tegmental area dopamine neurons in mice. | Kortleven C et al. | β | 2011 | β |
| Absence of NMDA receptors in dopamine neurons attenuates dopamine release but not conditioned approach during Pavlovian conditioning. | Parker JG et al. | β | 2010 | β |
| Acute and chronic cocaine differentially alter the subcellular distribution of AMPA GluR1 subunits in region-specific neurons within the mouse ventral tegmental area. | Lane DA et al. | β | 2010 | β |
| Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction. | Olive MF | β | 2010 | β |
| D1 and D2 dopamine receptors in separate circuits cooperate to drive associative long-term potentiation in the prefrontal cortex. | Xu TX et al. | β | 2010 | β |
| Dopamine inhibits GABA(A) currents in ventral tegmental area dopamine neurons via activation of presynaptic G-protein coupled inwardly-rectifying potassium channels. | Michaeli A et al. | β | 2010 | β |
| Drugs of abuse and stress impair LTP at inhibitory synapses in the ventral tegmental area. | Niehaus JL et al. | β | 2010 | β |
| Elevated BDNF after cocaine withdrawal facilitates LTP in medial prefrontal cortex by suppressing GABA inhibition. | Lu H et al. | β | 2010 | β |
| How conditioned stimuli acquire the ability to activate VTA dopamine cells: a proposed neurobiological component of reward-related learning. | Zellner MR et al. | β | 2010 | β |
| Lateral hypothalamic orexin/hypocretin neurons: A role in reward-seeking and addiction. | Aston-Jones G et al. | β | 2010 | β |
| Mechanisms involved in systemic nicotine-induced glutamatergic synaptic plasticity on dopamine neurons in the ventral tegmental area. | Gao M et al. | β | 2010 | β |
| Methamphetamine enhances memory of operantly conditioned respiratory behavior in the snail Lymnaea stagnalis. | Kennedy CD et al. | β | 2010 | β |
| Mixing pleasures: review of the effects of drugs on sex behavior in humans and animal models. | Frohmader KS et al. | β | 2010 | β |
| Netrin-1 receptor in the ventral tegmental area is required for sensitization to amphetamine. | Yetnikoff L et al. | β | 2010 | β |
| Neuroplastic alterations in the limbic system following cocaine or alcohol exposure. | Stuber GD et al. | β | 2010 | β |
| Neuroplasticity in the mesolimbic system induced by natural reward and subsequent reward abstinence. | Pitchers KK et al. | β | 2010 | β |
| NMDA receptors on non-dopaminergic neurons in the VTA support cocaine sensitization. | Luo Y et al. | β | 2010 | β |
| [Recent discoveries on the function and plasticity of central dopamine pathways]. | Thibault D et al. | β | 2010 | β |
| Synaptic neurotransmission depression in ventral tegmental dopamine neurons and cannabinoid-associated addictive learning. | Liu Z et al. | β | 2010 | β |
| Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuse. | Chen BT et al. | β | 2010 | β |
| The small-conductance calcium-activated potassium channel is a key modulator of firing and long-term depression in the dorsal striatum. | Hopf FW et al. | β | 2010 | β |
| Alcoholism: a systems approach from molecular physiology to addictive behavior. | Spanagel R | β | 2009 | β |
| AMPA receptor trafficking in the dorsal striatum is critical for behavioral sensitization to cocaine in juvenile mice. | Kim M et al. | β | 2009 | β |
| Astrocytic control of synaptic transmission and plasticity: a target for drugs of abuse? | Haydon PG et al. | β | 2009 | β |
| Burst-timing-dependent plasticity of NMDA receptor-mediated transmission in midbrain dopamine neurons. | Harnett MT et al. | β | 2009 | β |
| Cocaine exposure in utero alters synaptic plasticity in the medial prefrontal cortex of postnatal rats. | Lu H et al. | β | 2009 | β |
| Cocaine-induced LTP in the ventral tegmental area: new insights into mechanism and time course illuminate the cellular substrates of addiction. | Heshmati M | β | 2009 | β |
| Endocannabinoid signaling and long-term synaptic plasticity. | Heifets BD et al. | β | 2009 | β |
| GABA transporter-1 activity modulates hippocampal theta oscillation and theta burst stimulation-induced long-term potentiation. | Gong N et al. | β | 2009 | β |
| Genetic differences in hippocampal synaptic plasticity. | Prakash S et al. | β | 2009 | β |
| Imaging dopamine's role in drug abuse and addiction. | Volkow ND et al. | β | 2009 | β |
| Isoflurane anesthesia interferes with the expression of cocaine-induced sensitization in female rats. | Siegal N et al. | β | 2009 | β |
| Long-lasting modulation of glutamatergic transmission in VTA dopamine neurons after a single dose of benzodiazepine agonists. | Heikkinen AE et al. | β | 2009 | β |
| NR2A/B-containing NMDA receptors mediate cocaine-induced synaptic plasticity in the VTA and cocaine psychomotor sensitization. | Schumann J et al. | β | 2009 | β |
| Phasic dopamine release in appetitive behaviors and drug addiction. | Wanat MJ et al. | β | 2009 | β |
| Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. | Tsai HC et al. | β | 2009 | β |
| PKG and PKA signaling in LTP at GABAergic synapses. | Nugent FS et al. | β | 2009 | β |
| Plasticity of addiction: a mesolimbic dopamine short-circuit? | Niehaus JL et al. | β | 2009 | β |
| Role of lateral hypothalamic orexin neurons in reward processing and addiction. | Aston-Jones G et al. | β | 2009 | β |
| Src-protein tyrosine kinases are required for cocaine-induced increase in the expression and function of the NMDA receptor in the ventral tegmental area. | Schumann J et al. | β | 2009 | β |
| Strain specific synaptic modifications on ventral tegmental area dopamine neurons after ethanol exposure. | Wanat MJ et al. | β | 2009 | β |
| Synaptic AMPA receptor plasticity and behavior. | Kessels HW et al. | β | 2009 | β |
| Administration of the calcineurin inhibitor cyclosporine modulates cocaine-induced locomotor activity in rats. | Addy NA et al. | β | 2008 | β |
| Alpha-chemokines regulate proliferation, neurogenesis, and dopaminergic differentiation of ventral midbrain precursors and neurospheres. | Edman LC et al. | β | 2008 | β |
| Cocaine but not natural reward self-administration nor passive cocaine infusion produces persistent LTP in the VTA. | Chen BT et al. | β | 2008 | β |
| Cocaine disinhibits dopamine neurons in the ventral tegmental area via use-dependent blockade of GABA neuron voltage-sensitive sodium channels. | Steffensen SC et al. | β | 2008 | β |
| Cocaine-evoked synaptic plasticity: a key to addiction? | LΓΌscher C et al. | β | 2008 | β |
| D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling. | Pan B et al. | β | 2008 | β |
| Diazepam alters cocaine self-administration, but not cocaine-stimulated locomotion or nucleus accumbens dopamine. | Maier EY et al. | β | 2008 | β |
| Dose-dependent changes in the synaptic strength on dopamine neurons and locomotor activity after cocaine exposure. | Wanat MJ et al. | β | 2008 | β |
| Endocannabinoid signaling mediates cocaine-induced inhibitory synaptic plasticity in midbrain dopamine neurons. | Pan B et al. | β | 2008 | β |
| Functional implications of glutamatergic projections to the ventral tegmental area. | Geisler S et al. | β | 2008 | β |
| Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. | Engblom D et al. | β | 2008 | β |
| Glutamatergic substrates of drug addiction and alcoholism. | Gass JT et al. | β | 2008 | β |
| High-frequency afferent stimulation induces long-term potentiation of field potentials in the ventral tegmental area. | Nugent FS et al. | β | 2008 | β |
| Individual dopamine midbrain neurons: functional diversity and flexibility in health and disease. | Liss B et al. | β | 2008 | β |
| LTP of GABAergic synapses in the ventral tegmental area and beyond. | Nugent FS et al. | β | 2008 | β |
| Mechanism and time course of cocaine-induced long-term potentiation in the ventral tegmental area. | Argilli E et al. | β | 2008 | β |
| Neuroplasticity in the mesolimbic dopamine system and cocaine addiction. | Thomas MJ et al. | β | 2008 | β |
| Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons. | Borgland SL et al. | β | 2008 | β |
| Potential anatomical basis for attentional modulation of hippocampal neurons. | Rowland DC et al. | β | 2008 | β |
| Prominent activation of brainstem and pallidal afferents of the ventral tegmental area by cocaine. | Geisler S et al. | β | 2008 | β |
| Review. Psychological and neural mechanisms of relapse. | Stewart J | β | 2008 | β |
| Reward-predictive cues enhance excitatory synaptic strength onto midbrain dopamine neurons. | Stuber GD et al. | β | 2008 | β |
| Role of NMDA receptors in dopamine neurons for plasticity and addictive behaviors. | Zweifel LS et al. | β | 2008 | β |
| Spike timing-dependent long-term potentiation in ventral tegmental area dopamine cells requires PKC. | Luu P et al. | β | 2008 | β |
| Spike timing-dependent plasticity: a Hebbian learning rule. | Caporale N et al. | β | 2008 | β |
| The aspirin metabolite salicylate enhances neuronal excitation in rat hippocampal CA1 area through reducing GABAergic inhibition. | Gong N et al. | β | 2008 | β |
| Voluntary ethanol intake enhances excitatory synaptic strength in the ventral tegmental area. | Stuber GD et al. | β | 2008 | β |
| Activation of afferents to the ventral tegmental area in response to acute amphetamine: a double-labelling study. | Colussi-Mas J et al. | β | 2007 | β |
| Acute cocaine exposure alters spine density and long-term potentiation in the ventral tegmental area. | Sarti F et al. | β | 2007 | β |
| Chronic cocaine administration modulates the expression of transcription factors involved in midbrain dopaminergic neuron function. | Leo D et al. | β | 2007 | β |
| Cocaine and Pavlovian fear conditioning: dose-effect analysis. | Wood SC et al. | β | 2007 | β |
| Differential regulation of action potential- and metabotropic glutamate receptor-induced Ca2+ signals by inositol 1,4,5-trisphosphate in dopaminergic neurons. | Cui G et al. | β | 2007 | β |
| Dopamine alters AMPA receptor synaptic expression and subunit composition in dopamine neurons of the ventral tegmental area cultured with prefrontal cortex neurons. | Gao C et al. | β | 2007 | β |
| GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaine. | Lhuillier L et al. | β | 2007 | β |
| Group I mGluRs and long-term depression: potential roles in addiction? | Grueter BA et al. | β | 2007 | β |
| Long-term reduction in ventral tegmental area dopamine neuron population activity following repeated stimulant or ethanol treatment. | Shen RY et al. | β | 2007 | β |
| Neurotensin receptor antagonist administered during cocaine withdrawal decreases locomotor sensitization and conditioned place preference. | Felszeghy K et al. | β | 2007 | β |
| NMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. | Lau CG et al. | β | 2007 | β |
| Opioids block long-term potentiation of inhibitory synapses. | Nugent FS et al. | β | 2007 | β |
| Parallel loss of hippocampal LTD and cognitive flexibility in a genetic model of hyperdopaminergia. | Morice E et al. | β | 2007 | β |
| Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area. | Mameli M et al. | β | 2007 | β |
| Repeated cocaine administration impairs group II metabotropic glutamate receptor-mediated long-term depression in rat medial prefrontal cortex. | Huang CC et al. | β | 2007 | β |
| Repeated cocaine administration promotes long-term potentiation induction in rat medial prefrontal cortex. | Huang CC et al. | β | 2007 | β |
| Synaptic activation of dendritic AMPA and NMDA receptors generates transient high-frequency firing in substantia nigra dopamine neurons in vitro. | Blythe SN et al. | β | 2007 | β |
| Synaptic plasticity and addiction. | Kauer JA et al. | β | 2007 | β |
| Withdrawal from intermittent ethanol exposure increases probability of burst firing in VTA neurons in vitro. | Hopf FW et al. | β | 2007 | β |
| Altered cortico-striatal synaptic plasticity and related behavioural impairments in reeler mice. | Marrone MC et al. | β | 2006 | β |
| BDNF-dependent synaptic sensitization in midbrain dopamine neurons after cocaine withdrawal. | Pu L et al. | β | 2006 | β |
| Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. | Venton BJ et al. | β | 2006 | β |
| Cocaine triggered AMPA receptor redistribution is reversed in vivo by mGluR-dependent long-term depression. | Bellone C et al. | β | 2006 | β |
| Drug addiction: the neurobiology of disrupted self-control. | Baler RD et al. | β | 2006 | β |
| Encoding of motion targets by waves in turtle visual cortex. | Du X et al. | β | 2006 | β |
| Leptin receptor signaling in midbrain dopamine neurons regulates feeding. | Hommel JD et al. | β | 2006 | β |
| Methamphetamine induces long-term changes in GABAA receptor alpha2 subunit and GAD67 expression. | Zhang X et al. | β | 2006 | β |
| Repeated cocaine effects on learning, memory and extinction in the pond snail Lymnaea stagnalis. | Carter K et al. | β | 2006 | β |
| The role of synaptic ion channels in synaptic plasticity. | Voglis G et al. | β | 2006 | β |
| The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons? | Margolis EB et al. | β | 2006 | β |