Drug addiction as a pathology of staged neuroplasticity.
paper
Cited
Public
Unavailable
- Authors
- Kalivas, Peter W; O'Brien, Charles
- Year
- 2008
- Journal
- Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
- PMID
- 17805308
- DOI
- 10.1038/sj.npp.1301564
Using addictive drugs can evolve from controlled social use into the compulsive relapsing disorder that characterizes addiction. This transition to addiction results from genetic, developmental, and sociological vulnerabilities, combined with pharmacologically induced plasticity in brain circuitry that strengthens learned drug-associated behaviors at the expense of adaptive responding for natural rewards. Advances over the last decade have identified the brain circuits most vulnerable to drug-induced changes, as well as many associated molecular and morphological underpinnings. This growing knowledge has contributed to an expanded understanding of how drugs usurp normal learning circuitry to create the pathology of addiction, as evidenced by involuntary activation of reward circuits in response to drug-associated cues and simultaneous reports of drug craving. This new understanding provides unprecedented potential opportunities for novel pharmacotherapeutic targets in treating addiction. There appears to be plasticity associated with the addiction phenomenon in general as well as changes produced by addiction to a specific class of addicting drugs. These findings also provide the basis for the current understanding of addiction as a chronic, relapsing disease of the brain with changes that persist long after the last use of the drug. Here, we describe the neuroplasticity in brain circuits and cell function induced by addictive drugs that is thought to underlie the compulsions to resume drug-taking, and discuss how this knowledge is impelling exploration and testing of novel addiction therapies.
No figures extracted from this document.
No chunks โ full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A large-scale DNA methylation study of alcohol use identified robust associations and cell-type specific insights. | Clark SL et al. | โ | 2026 | โ |
| Astrocytes in the Circadian System: A Promising Target for Mood Disorder Interventions. | Liu P et al. | โ | 2026 | โ |
| Design, Synthesis, and Pharmacokinetic Profiling of Fluorinated Reversible <i>N</i>-Alkyl Carbamate Derivatives of Psilocin for Sub-Hallucinogenic Brain Exposure. | Banzato M et al. | โ | 2026 | โ |
| <i>BDNF</i> gene polymorphisms and substance use disorders: a systematic review. | Peregud D et al. | โ | 2026 | โ |
| Modulatory effects of orexin and dynorphin on stress-related alcohol seeking and relapse: pivotal role of the posterior paraventricular nucleus of the thalamus. | Holguin G et al. | โ | 2026 | โ |
| Abnormal regional brain activity associated with relapse in early abstinent methamphetamine-dependent individuals. | Ma M et al. | โ | 2025 | โ |
| A Cocaine-Activated Ensemble Exerts Increased Control Over Behavior While Decreasing in Size. | Thibeault KC et al. | โ | 2025 | โ |
| Endogenous regulator of G protein signaling 14 (RGS14) blunts cocaine-induced emotionally motivated behaviors in female mice. | Bramlett SN et al. | โ | 2025 | โ |
| Neuroplasticity and psychedelics: A comprehensive examination of classic and non-classic compounds in pre and clinical models. | Agnorelli C et al. | โ | 2025 | โ |
| Novel neurotherapeutic targets for substance use disorders: Neuroplasticity, neuroinflammation, gasotransmitters and non-canonical organ systems. | Sharma P et al. | โ | 2025 | โ |
| Regulation of glial markers expression in the rat basolateral amygdala and hippocampus during morphine aversive memory retrieval and its extinction. | Franco-Garcรญa A et al. | โ | 2025 | โ |
| The Role of Lactate in Drug Addiction. | Chen R et al. | โ | 2025 | โ |
| A gut (microbiome) feeling about addiction: Interactions with stress and social systems. | Garcรญa-Cabrerizo R et al. | โ | 2024 | โ |
| Blunted reward-related activation to food scenes distinguishes individuals with alcohol use disorder in a pilot case-control fMRI pilot study. | Mellick W et al. | โ | 2024 | โ |
| Conditioning- and reward-related dendritic and presynaptic plasticity of nucleus accumbens neurons in male and female sign-tracker rats. | Colom M et al. | โ | 2024 | โ |
| Effects of Beta Lactams on Behavioral Outcomes of Substance Use Disorders: A Meta-Analysis of Preclinical Studies. | Alasmari MS et al. | โ | 2024 | โ |
| Lifestyle Behaviors in Patients With Gastric Cancer: Continuous Need for Alcohol Abstinence and Muscle Strength Training Education. | Seo JW et al. | โ | 2024 | โ |
| Mesocorticolimbic system reactivity to alcohol use-related visual cues as a function of alcohol sensitivity phenotype: A pilot fMRI study. | Cofresรญ RU et al. | โ | 2024 | โ |
| Pre- and postsynaptic signatures in the prelimbic cortex associated with "alcohol use disorder" in the rat. | Domi A et al. | โ | 2024 | โ |
| Substance use and spine density: a systematic review and meta-analysis of preclinical studies. | Oliva HNP et al. | โ | 2024 | โ |
| Targeting the cytoskeleton as a therapeutic approach to substance use disorders. | Pandey S et al. | โ | 2024 | โ |
| The nucleus accumbens in reward and aversion processing: insights and implications. | Xu Y et al. | โ | 2024 | โ |
| ADX106772, an mGlu2 receptor positive allosteric modulator, selectively attenuates oxycodone taking and seeking. | Illenberger JM et al. | โ | 2023 | โ |
| Age at onset of alcohol consumption and its association with alcohol misuse in adulthood. | Kim SY et al. | โ | 2023 | โ |
| Alcohol Cue Processing in Co-Occurring Bipolar Disorder and Alcohol Use Disorder. | Mellick WH et al. | โ | 2023 | โ |
| Association of GABA receptor delta subunit gene variations with increased risk of methamphetamine dependence. | Xie X et al. | โ | 2023 | โ |
| Critical appraisal and systematic review of genes linked with cocaine addiction, depression and anxiety. | Kaushik S et al. | โ | 2023 | โ |
| Cue-induced reinstatement of seeking behavior in male rats is independent from the rewarding value of the primary reinforcer: Effect of mGluR5 blockade. | Kallupi M et al. | โ | 2023 | โ |
| Distinctive Neuroanatomic Regions Involved in Cocaine-Induced Behavioral Sensitization in Mice. | Santos-Baldaia RD et al. | โ | 2023 | โ |
| Evaluation of the effect of mesenchymal stem cells injection in the nucleus accumbens on the morphine reinstatement behavior in a conditioned place preference model in Wistar rat: Expression changes of NMDA receptor subunits and NT-3. | Dousti Kataj P et al. | โ | 2023 | โ |
| Glutamate levels in the ventromedial prefrontal cortex and resting-state functional connectivity within reward circuits in alcohol-dependent patients. | Hu Y et al. | โ | 2023 | โ |
| Impact of combination of intermittent theta burst stimulation and methadone maintenance treatment in individuals with opioid use disorder: A comparative study. | Gong H et al. | โ | 2023 | โ |
| miRNAs and Substances Abuse: Clinical and Forensic Pathological Implications: A Systematic Review. | Occhipinti C et al. | โ | 2023 | โ |
| Net gain and loss: influence of natural rewards and drugs of abuse on perineuronal nets. | Brown TE et al. | โ | 2023 | โ |
| Plasma endocannabinoids in cocaine dependence and their relation to cerebral metabotropic glutamate receptor 5 density. | Kroll SL et al. | โ | 2023 | โ |
| Psychedelic Targeting of Metabotropic Glutamate Receptor 2 and Its Implications for the Treatment of Alcoholism. | Domanegg K et al. | โ | 2023 | โ |
| Relationship between carotid intima-media thickness (cIMT) and dual-system imbalance in tobacco dependence: An rs-fMRI research. | Tan Q et al. | โ | 2023 | โ |
| Striatal hypoactivation during monetary loss anticipation in individuals with substance use disorders in a heterogenous urban American Indian sample. | Wilhelm RA et al. | โ | 2023 | โ |
| Synaptic plasticity and mental health: methods, challenges and opportunities. | Appelbaum LG et al. | โ | 2023 | โ |
| Targeted neuroplasticity in spatiotemporally patterned invasive neuromodulation therapies for improving clinical outcomes. | Asp AJ et al. | โ | 2023 | โ |
| Twisted memories: Addiction-related engrams are strengthened by desire thinking. | Mattioni L et al. | โ | 2023 | โ |
| ฮฑ2ฮด-1 protein drives opioid-induced conditioned reward and synaptic NMDA receptor hyperactivity in the nucleus accumbens. | Jin D et al. | โ | 2023 | โ |
| Alcohol-Endocannabinoid Interactions: Implications for Addiction-Related Behavioral Processes. | Serrano A et al. | โ | 2022 | โ |
| A Subset of Nucleus Accumbens Neurons Receiving Dense and Functional Prelimbic Cortical Input Are Required for Cocaine Seeking. | Siemsen BM et al. | โ | 2022 | โ |
| Buprenorphine reduces methamphetamine intake and drug seeking behavior <i>via</i> activating nociceptin/orphanin FQ peptide receptor in rats. | Wang F et al. | โ | 2022 | โ |
| Cocaine induces input and cell-type-specific synaptic plasticity in ventral pallidum-projecting nucleus accumbens medium spiny neurons. | Inbar K et al. | โ | 2022 | โ |
| Does Traumatic Brain Injury Cause Risky Substance Use or Substance Use Disorder? | Olsen CM et al. | โ | 2022 | โ |
| Effects of heroin self-administration and forced withdrawal on the expression of genes related to the mTOR network in the basolateral complex of the amygdala of male Lewis rats. | Ucha M et al. | โ | 2022 | โ |
| Effects of Methylphenidate on the Dopamine Transporter and Beyond. | Zetterstrรถm TSC et al. | โ | 2022 | โ |
| Electrophysiological and behavioral correlates of cannabis use disorder. | Andriot T et al. | โ | 2022 | โ |
| Functional Genomic Analysis of Amphetamine Sensitivity in <i>Drosophila</i>. | Karam CS et al. | โ | 2022 | โ |
| Inhibition of a cortico-thalamic circuit attenuates cue-induced reinstatement of drug-seeking behavior in "relapse prone" male rats. | Kuhn BN et al. | โ | 2022 | โ |
| Logical fallacies and misinterpretations that hinder progress in translational addiction neuroscience. | Strickland JC et al. | โ | 2022 | โ |
| Mysterious long noncoding RNAs and their relationships to human disease. | Li W et al. | โ | 2022 | โ |
| Protein kinases in natural versus drug reward. | Amaral IM et al. | โ | 2022 | โ |
| Psychedelics and Neural Plasticity: Therapeutic Implications. | Grieco SF et al. | โ | 2022 | โ |
| Rapastinel accelerates loss of withdrawal signs after repeated morphine and blunts relapse to conditioned place preference. | Armstrong C et al. | โ | 2022 | โ |
| Sex film viewing, but not hypersexual concerns, are associated with more sexual arousal in anticipation of an intimate partner experience. | Prause N et al. | โ | 2022 | โ |
| The effect of self-administered methamphetamine on GABAergic interneuron populations and functional connectivity of the nucleus accumbens and prefrontal cortex. | Robinson KJ et al. | โ | 2022 | โ |
| The particularity of freedom and recovery from addiction in practice: On the therapeutic limitations of generalising addiction science. | Weinberg D | โ | 2022 | โ |
| The Use of Olanzapine for Nonmedical Opioid Use in a Patient with Cancer Receiving Palliative Care. | Juliรฃo M et al. | โ | 2022 | โ |
| The Ventral Tegmental Area and Nucleus Accumbens as Circadian Oscillators: Implications for Drug Abuse and Substance Use Disorders. | Becker-Krail DD et al. | โ | 2022 | โ |
| Association study of genetic polymorphisms in <i>GABRD</i> with treatment response and dose in methadone maintenance treatment. | Xie X et al. | โ | 2021 | โ |
| Cocaine-Induced Changes in Tonic Dopamine Concentrations Measured Using Multiple-Cyclic Square Wave Voltammetry <i>in vivo</i>. | Yuen J et al. | โ | 2021 | โ |
| Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics. | Le TM et al. | โ | 2021 | โ |
| Dopamine D<sub>4</sub> Receptor Is a Regulator of Morphine-Induced Plasticity in the Rat Dorsal Striatum. | Rivera A et al. | โ | 2021 | โ |
| Drinking Pattern in Intermittent Access Two-Bottle-Choice Paradigm in Male Wistar Rats Is Associated with Exon-Specific BDNF Expression in the Hippocampus During Early Abstinence. | Peregud D et al. | โ | 2021 | โ |
| Effects of ceftriaxone on ethanol drinking and GLT-1 expression in ethanol dependence and relapse drinking. | Griffin WC et al. | โ | 2021 | โ |
| Energy sensors in drug addiction: A potential therapeutic target. | Lรณpez-Gambero AJ et al. | โ | 2021 | โ |
| Improved Executive Functions and Reduced Craving in Youths with Methamphetamine Addiction: Evidence from Combined Transcranial Direct Current Stimulation with Mindfulness Treatment. | Alizadehgoradel J et al. | โ | 2021 | โ |
| Increased Expression of Plasma miRNA-320a and let-7b-5p in Heroin-Dependent Patients and Its Clinical Significance. | Liu H et al. | โ | 2021 | โ |
| Inhibition of striatal SEZ6 by miR-3594-5p is a drug-specific marker for late-stage heroin intake escalation | Lenoir M et al. | โ | 2021 | โ |
| Initial Study on COMT and DRD2 Gene Polymorphisms as Well as the Influence of Temperament and Character Trait on the Severity of Alcohol Craving in Alcohol-Dependent Patients. | Czarnecki D et al. | โ | 2021 | โ |
| Microbiota-gut-brain axis as a regulator of reward processes. | Garcรญa-Cabrerizo R et al. | โ | 2021 | โ |
| Neural mechanisms of sexual decision-making in women with alcohol use disorder. | Folco KL et al. | โ | 2021 | โ |
| Neuronal activity associated with cocaine preference: Effects of differential cocaine intake. | Chow JJ et al. | โ | 2021 | โ |
| Predictors of Habitual and Addictive Smartphone Behavior in Problematic Smartphone Use. | Park J et al. | โ | 2021 | โ |
| Regulation of dopamine-dependent transcription and cocaine action by Gadd45b. | Zipperly ME et al. | โ | 2021 | โ |
| Symphony of Well-Being: Harmony Between Neural Variability and Self-Construal. | Fan L et al. | โ | 2021 | โ |
| The cue-reactivity paradigm: An ensemble of networks driving attention and cognition when viewing drug and natural reward-related stimuli. | Hill-Bowen LD et al. | โ | 2021 | โ |
| Transcranial magnetic stimulation neurophysiology of patients with major depressive disorder: a systematic review and meta-analysis. | Kinjo M et al. | โ | 2021 | โ |
| Treating cocaine and opioid use disorder with transcranial magnetic stimulation: A path forward. | Steele VR et al. | โ | 2021 | โ |
| 7, 8-Dihydroxy-4-methylcoumarin reverses depression model-induced depression-like behaviors and alteration of dendritic spines in the mood circuits. | Yang M et al. | โ | 2020 | โ |
| A Neurobiological Model of Alcohol Marketing Effects on Underage Drinking. | Courtney AL et al. | โ | 2020 | โ |
| A novel method to study reward-context associations and drug-seeking behaviors. | McKendrick G et al. | โ | 2020 | โ |
| A Single Ketamine Infusion Combined With Motivational Enhancement Therapy for Alcohol Use Disorder: A Randomized Midazolam-Controlled Pilot Trial. | Dakwar E et al. | โ | 2020 | โ |
| Ayahuasca blocks the reinstatement of methylphenidate-induced conditioned place preference in mice: behavioral and brain Fos expression evaluations. | Reis HS et al. | โ | 2020 | โ |
| Blockade of D3 receptor prevents changes in DAT and D3R expression in the mesolimbic dopaminergic circuit produced by social stress- and cocaine prime-induced reinstatement of cocaine-CPP. | Guerrero-Bautista R et al. | โ | 2020 | โ |
| Blockade of Orexin Receptors in the Posterior Paraventricular Nucleus of the Thalamus Prevents Stress-Induced Reinstatement of Reward-Seeking Behavior in Rats With a History of Ethanol Dependence. | Matzeu A et al. | โ | 2020 | โ |
| Chemogenetic Manipulation of Dopamine Neurons Dictates Cocaine Potency at Distal Dopamine Transporters. | Brodnik ZD et al. | โ | 2020 | โ |
| Complementary Roles for Ventral Pallidum Cell Types and Their Projections in Relapse. | Prasad AA et al. | โ | 2020 | โ |
| Effects of brief inhibition of the ventral tegmental area dopamine neurons on the cocaine seeking during abstinence. | Solecki W et al. | โ | 2020 | โ |
| Enriched Environment Ameliorates Cognitive Deficits and Locomotor Sensitization in Morphine-Withdrawn Rats Receiving Methadone Maintenance Treatment. | Akbari P et al. | โ | 2020 | โ |
| From apathy to addiction: Insights from neurology and psychiatry. | Kirschner M et al. | โ | 2020 | โ |
| Levo-tetrahydropalmatine attenuates methamphetamine reward behavior and the accompanying activation of ERK phosphorylation in mice. | Su H et al. | โ | 2020 | โ |
| Long-term exposure to ephedrine leads to neurotoxicity and neurobehavioral disorders accompanied by up-regulation of CRF in prefrontal cortex and hippocampus in rhesus macaques. | Duan S et al. | โ | 2020 | โ |
| Mindfulness and Behavior Change. | Schuman-Olivier Z et al. | โ | 2020 | โ |
| Mindfulness as a predictor of cognitive-behavioral therapy outcomes in inner-city adults with posttraumatic stress and substance dependence. | Vujanovic AA et al. | โ | 2020 | โ |
| N-Acetylcysteine treatment during acute stress prevents stress-induced augmentation of addictive drug use and relapse. | Garcia-Keller C et al. | โ | 2020 | โ |
| Possible Role of CRF-Hcrt Interaction in the Infralimbic Cortex in the Emergence and Maintenance of Compulsive Alcohol-Seeking Behavior. | Kim JS et al. | โ | 2020 | โ |
| Preliminary examination of the orexin system on relapse-related factors in cocaine use disorder. | Suchting R et al. | โ | 2020 | โ |
| Prescription psychostimulants for the treatment of stimulant use disorder: a systematic review and meta-analysis. | Tardelli VS et al. | โ | 2020 | โ |
| Re-wiring Guilt: How Advancing Neuroscience Encourages Strategic Interventions Over Retributive Justice. | Anderson NE et al. | โ | 2020 | โ |
| rTMS-Induced Changes in Glutamatergic and Dopaminergic Systems: Relevance to Cocaine and Methamphetamine Use Disorders. | Moretti J et al. | โ | 2020 | โ |
| Targeting the Orexin System for Prescription Opioid Use Disorder. | Matzeu A et al. | โ | 2020 | โ |
| Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure. | Moreira da Silva Santos A et al. | โ | 2020 | โ |
| Toll-Like Receptor 4 Signaling and Drug Addiction. | Wu R et al. | โ | 2020 | โ |
| Transcranial Direct Current Stimulation Applied to the Dorsolateral and Ventromedial Prefrontal Cortices in Smokers Modifies Cognitive Circuits Implicated in the Nicotine Withdrawal Syndrome. | Aronson Fischell S et al. | โ | 2020 | โ |
| Transcranial Magnetic Stimulation as an Interventional Tool for Addiction. | Steele VR | โ | 2020 | โ |
| Translational dynamics of alcohol tolerance of preclinical models and human laboratory studies. | Haass-Koffler CL et al. | โ | 2020 | โ |
| An evaluation of the impact of co-occurring anxiety and substance use disorder on bipolar disorder illness outcomes in STEP-BD. | Prisciandaro JJ et al. | โ | 2019 | โ |
| Brain Structure Alterations in Poly-Drug Use: Reduced Cortical Thickness and White Matter Impairments in Regions Associated With Affective, Cognitive, and Motor Functions. | Unterrainer HF et al. | โ | 2019 | โ |
| Cognitive enhancers as a treatment for heroin relapse and addiction. | Ma B et al. | โ | 2019 | โ |
| Current Understanding of Methamphetamine-Associated Metabolic Changes Revealed by the Metabolomics Approach. | Kim M et al. | โ | 2019 | โ |
| Effects of ketamine treatment on cocaine-induced reinstatement and disruption of functional connectivity in unanesthetized rhesus monkeys. | Maltbie EA et al. | โ | 2019 | โ |
| Genome-edited skin epidermal stem cells protect mice from cocaine-seeking behaviour and cocaine overdose. | Li Y et al. | โ | 2019 | โ |
| Hypothesis of the optimal therapeutic effect of transcranial direct current stimulation (tDCS) for psychiatric disorders: Integration of positive cognitive tasks during the neuroplastic process. | Lin SH et al. | โ | 2019 | โ |
| Ketamine can reduce harmful drinking by pharmacologically rewriting drinking memories. | Das RK et al. | โ | 2019 | โ |
| Role of prefrontal cortex in the extinction of drug memories. | Zhang WH et al. | โ | 2019 | โ |
| Selective dopamine D3 receptor antagonist YQA14 inhibits morphine-induced behavioral sensitization in wild type, but not in dopamine D3 receptor knockout mice. | Lv Y et al. | โ | 2019 | โ |
| The Sigma-1 Receptor: When Adaptive Regulation of Cell Electrical Activity Contributes to Stimulant Addiction and Cancer. | Soriani O et al. | โ | 2019 | โ |
| Cocaine-Induced Structural Plasticity in Input Regions to Distinct Cell Types in Nucleus Accumbens. | Barrientos C et al. | โ | 2018 | โ |
| Craving Behavior from Opioid Addiction Controlled with Olanzapine in an Advanced Cancer Patient: A Case Report. | Go SI et al. | โ | 2018 | โ |
| DARK Classics in Chemical Neuroscience: Methamphetamine. | Abbruscato TJ et al. | โ | 2018 | โ |
| Drug Seeking and Relapse: New Evidence of a Role for Orexin and Dynorphin Co-transmission in the Paraventricular Nucleus of the Thalamus. | Matzeu A et al. | โ | 2018 | โ |
| Expression map of 78 brain-expressed mouse orphan GPCRs provides a translational resource for neuropsychiatric research. | Ehrlich AT et al. | โ | 2018 | โ |
| Food additives, food and the concept of 'food addiction': Is stimulation of the brain reward circuit by food sufficient to trigger addiction? | Onaolapo AY et al. | โ | 2018 | โ |
| Formation of Opioid-Induced Memory and Its Prevention: A Computational Study. | Borjkhani M et al. | โ | 2018 | โ |
| Heroin-induced suppression of saccharin intake in OPRM1 A118G mice. | Freet CS et al. | โ | 2018 | โ |
| In silico identification and in vivo validation of miR-495 as a novel regulator of motivation for cocaine that targets multiple addiction-related networks in the nucleus accumbens. | Bastle RM et al. | โ | 2018 | โ |
| Levodopa prevents the reinstatement of cocaine self-administration in rats via potentiation of dopamine release in the medial prefrontal cortex. | Antinori S et al. | โ | 2018 | โ |
| Machine Learning of Functional Magnetic Resonance Imaging Network Connectivity Predicts Substance Abuse Treatment Completion. | Steele VR et al. | โ | 2018 | โ |
| Mechanisms Underlying the Risk to Develop Drug Addiction, Insights From Studies in <i>Drosophila melanogaster</i>. | Ryvkin J et al. | โ | 2018 | โ |
| Melatonin in drug addiction and addiction management: Exploring an evolving multidimensional relationship. | Onaolapo OJ et al. | โ | 2018 | โ |
| Opioid and Psychostimulant Plasticity: Targeting Overlap in Nucleus Accumbens Glutamate Signaling. | Hearing M et al. | โ | 2018 | โ |
| PET Imaging Reveals Brain Metabolic Changes in Adolescent Rats Following Chronic Escalating Morphine Administration. | Chen Q et al. | โ | 2018 | โ |
| Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking. | Parrilla-Carrero J et al. | โ | 2018 | โ |
| Rewiring the Addicted Brain: Circuits-Based Treatment for Addiction. | Madeo G et al. | โ | 2018 | โ |
| Role of glutamatergic system and mesocorticolimbic circuits in alcohol dependence. | Alasmari F et al. | โ | 2018 | โ |
| Selective effects of ฮ9-tetrahydrocannabinol on medium spiny neurons in the striatum. | Fernรกndez-Cabrera MR et al. | โ | 2018 | โ |
| Self-regulation of the dopaminergic reward circuit in cocaine users with mental imagery and neurofeedback. | Kirschner M et al. | โ | 2018 | โ |
| Smoking Cessation With 20 Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Applied to Two Brain Regions: A Pilot Study. | Chang D et al. | โ | 2018 | โ |
| Youth Depression Alleviation-Augmentation with an anti-inflammatory agent (YoDA-A): protocol and rationale for a placebo-controlled randomized trial of rosuvastatin and aspirin. | Quinn AL et al. | โ | 2018 | โ |
| A Clinician's Guide to Co-occurring ADHD among Adolescent Substance Users: Comorbidity, Neurodevelopmental Risk, and Evidence-based Treatment Options. | Hogue A et al. | โ | 2017 | โ |
| Alcohol and nicotine interactions: pre-clinical models of dependence. | Tarren JR et al. | โ | 2017 | โ |
| A single cocaine exposure disrupts actin dynamics in the cortico-accumbal pathway of adolescent rats: modulation by a second cocaine injection. | Caffino L et al. | โ | 2017 | โ |
| Chronic methylphenidate regulates genes and proteins mediating neuroplasticity in the juvenile rat brain. | Quansah E et al. | โ | 2017 | โ |
| Circuit and Synaptic Plasticity Mechanisms of Drug Relapse. | Dong Y et al. | โ | 2017 | โ |
| Cocaine preexposure enhances sexual conditioning and increases resistance to extinction in male Japanese quail. | Akins CK et al. | โ | 2017 | โ |
| Cocaine self-administration disrupted by the N-methyl-D-aspartate receptor antagonist ketamine: a randomized, crossover trial. | Dakwar E et al. | โ | 2017 | โ |
| Data do not support sex as addictive. | Prause N et al. | โ | 2017 | โ |
| Dose-Dependent Effects of Binge-Like Methamphetamine Dosing on Dopamine and Neurotrophin Levels in Rat Brain. | Moreira da Silva Santos A et al. | โ | 2017 | โ |
| Early adverse experience and substance addiction: dopamine, oxytocin, and glucocorticoid pathways. | Kim S et al. | โ | 2017 | โ |
| Effects of Intermittent Alcohol Exposure on Emotion and Cognition: A Potential Role for the Endogenous Cannabinoid System and Neuroinflammation. | Sanchez-Marin L et al. | โ | 2017 | โ |
| Gene expression profiling in the human alcoholic brain. | Warden AS et al. | โ | 2017 | โ |
| Glucocorticoid receptor but not mineralocorticoid receptor mediates the activation of ERK pathway and CREB during morphine withdrawal. | Navarro-Zaragoza J et al. | โ | 2017 | โ |
| Hypocretin receptor 1 blockade produces bimodal modulation of cocaine-associated mesolimbic dopamine signaling. | Levy KA et al. | โ | 2017 | โ |
| Minding the brain: the role of pharmacotherapy in substance-use disorder treatment. | Elias D et al. | โ | 2017 | โ |
| Modeling Causal Relationships among Brain Areas in the Mesocorticolimbic System during Resting-State in Cocaine Users Utilizing a Graph Theoretic Approach. | Ray S et al. | โ | 2017 | โ |
| On Mourning and Recovery: Integrating Stages of Grief and Change Toward a Neuroscience-Based Model of Attachment Adaptation in Addiction Treatment. | Chambers RA et al. | โ | 2017 | โ |
| Perseveration of craving: effects of stimuli conditioned to drugs of abuse versus conventional reinforcers differing in demand. | Martin-Fardon R et al. | โ | 2017 | โ |
| Persistent strengthening of the prefrontal cortex - nucleus accumbens pathway during incubation of cocaine-seeking behavior. | Luรญs C et al. | โ | 2017 | โ |
| Posttraumatic Stress Disorder and Alcohol Use Disorder: Aย Critical Review of Pharmacologic Treatments. | Petrakis IL et al. | โ | 2017 | โ |
| Restructuring Reward Mechanisms in Nicotine Addiction: A Pilot fMRI Study of Mindfulness-Oriented Recovery Enhancement for Cigarette Smokers. | Froeliger B et al. | โ | 2017 | โ |
| Role of perineuronal nets in the anterior dorsal lateral hypothalamic area in the acquisition of cocaine-induced conditioned place preference and self-administration. | Blacktop JM et al. | โ | 2017 | โ |
| Sodium butyrate modulates a methamphetamine-induced conditioned place preference. | Zhu J et al. | โ | 2017 | โ |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | โ | 2017 | โ |
| The impact of junk foods on the adolescent brain. | Reichelt AC et al. | โ | 2017 | โ |
| ฮผNeurocircuitry: Establishing <i>in vitro</i> models of neurocircuits with human neurons. | Fantuzzo JA et al. | โ | 2017 | โ |
| Adaptive Plasticity in the Hippocampus of Young Mice Intermittently Exposed to MDMA Could Be the Origin of Memory Deficits. | Abad S et al. | โ | 2016 | โ |
| A Highly Polymorphic Copy Number Variant in the NSF Gene is Associated with Cocaine Dependence. | Cabana-Domรญnguez J et al. | โ | 2016 | โ |
| Alcohol consumption increases locomotion in an open field and induces Fos-immunoreactivity in reward and approach/withdrawal-related neurocircuitries. | Wscieklica T et al. | โ | 2016 | โ |
| Annual Research Review: On the developmental neuropsychology of substance use disorders. | Conrod PJ et al. | โ | 2016 | โ |
| Association between genetic variations of NMDA receptor NR3 subfamily genes and heroin addiction in male Han Chinese. | Xie X et al. | โ | 2016 | โ |
| Brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity. | Li W et al. | โ | 2016 | โ |
| Cannabidiol, neuroprotection and neuropsychiatric disorders. | Campos AC et al. | โ | 2016 | โ |
| Combined Effects of Simultaneous Exposure to Caffeine and Cocaine in the Mouse Striatum. | Muรฑiz JA et al. | โ | 2016 | โ |
| Conditioned stress prevents cue-primed cocaine reinstatement only in stress-responsive rats. | Hadad NA et al. | โ | 2016 | โ |
| Context- and time-dependent neurobiological and behavioral sensitization induced by a single morphine exposure in mice. | Qin WJ et al. | โ | 2016 | โ |
| Contingent and non-contingent recreational-like exposure to ethanol alters BDNF expression and signaling in the cortico-accumbal network differently. | Orrรน A et al. | โ | 2016 | โ |
| Corruption of the dentate gyrus by "dominant" granule cells: Implications for dentate gyrus function in health and disease. | Scharfman HE et al. | โ | 2016 | โ |
| Corticostriatal circuitry in regulating diseases characterized by intrusive thinking. | Kalivas BC et al. | โ | 2016 | โ |
| Demethylation of c-MYB binding site mediates upregulation of Bdnf IV in cocaine-conditioned place preference. | Tian W et al. | โ | 2016 | โ |
| Dendritic Spines in Depression: What We Learned from Animal Models. | Qiao H et al. | โ | 2016 | โ |
| Disrupting GluA2 phosphorylation potentiates reinstatement of cocaine seeking. | Briand LA et al. | โ | 2016 | โ |
| Effective Connectivity within the Mesocorticolimbic System during Resting-State in Cocaine Users. | Ray S et al. | โ | 2016 | โ |
| Enhancing second-order conditioning with lesions of the basolateral amygdala. | Holland PC | โ | 2016 | โ |
| Impact of partial dopamine depletion on cognitive flexibility in BDNF heterozygous mice. | Parikh V et al. | โ | 2016 | โ |
| MicroRNAs Are Involved in the Development of Morphine-Induced Analgesic Tolerance and Regulate Functionally Relevant Changes in Serpini1. | Tapocik JD et al. | โ | 2016 | โ |
| Morphine-induced locomotor sensitization produces structural plasticity in the mesocorticolimbic system dependent on CB1-R activity. | Guegan T et al. | โ | 2016 | โ |
| Neuronal metabolomics by ion mobility mass spectrometry in cocaine self-administering rats after early and late withdrawal. | Zhang X et al. | โ | 2016 | โ |
| Noninvasive brain stimulation for addiction medicine: From monitoring to modulation. | Yavari F et al. | โ | 2016 | โ |
| Prenatal cocaine exposure and its impact on cognitive functions of offspring: a pathophysiological insight. | Gkioka E et al. | โ | 2016 | โ |
| Romantic Love vs. Drug Addiction May Inspire a New Treatment for Addiction. | Zou Z et al. | โ | 2016 | โ |
| Sex differences in drug addiction and response to exercise intervention: From human to animal studies. | Zhou Y et al. | โ | 2016 | โ |
| Social Isolation Blunted the Response of Mesocortical Dopaminergic Neurons to Chronic Ethanol Voluntary Intake. | Lallai V et al. | โ | 2016 | โ |
| The effects of morphine treatment on the NCAM and its signaling in the MLDS of rats. | Cao JP et al. | โ | 2016 | โ |
| The effects of social contact on cocaine intake under extended-access conditions in male rats. | Robinson AM et al. | โ | 2016 | โ |
| The Extracellular Matrix Protein Brevican Limits Time-Dependent Enhancement of Cocaine Conditioned Place Preference. | Lubbers BR et al. | โ | 2016 | โ |
| The mGluR5 antagonist MPEP suppresses the expression and reinstatement, but not the acquisition, of the ethanol-conditioned place preference in mice. | Lee JY et al. | โ | 2016 | โ |
| The motor way: Clinical implications of understanding and shaping actions with the motor system in autism and drug addiction. | Casartelli L et al. | โ | 2016 | โ |
| The Nociceptin Receptor as an Emerging Molecular Target for Cocaine Addiction. | Lutfy K et al. | โ | 2016 | โ |
| ZNF804A variants confer risk for heroin addiction and affect decision making and gray matter volume in heroin abusers. | Sun Y et al. | โ | 2016 | โ |
| Abnormal context-reward associations in an immune-mediated neurodevelopmental mouse model with relevance to schizophrenia. | Labouesse MA et al. | โ | 2015 | โ |
| Amygdalar neuronal plasticity and the interactions of alcohol, sex, and stress. | Retson TA et al. | โ | 2015 | โ |
| Anisomycin in the medial prefrontal cortex reduces reconsolidation of cocaine-associated memories in the rat self-administration model. | Sorg BA et al. | โ | 2015 | โ |
| Basal Hippocampal Activity and Its Functional Connectivity Predicts Cocaine Relapse. | Adinoff B et al. | โ | 2015 | โ |
| Brain pathways to recovery from alcohol dependence. | Cui C et al. | โ | 2015 | โ |
| Ceftriaxone attenuates ethanol drinking and restores extracellular glutamate concentration through normalization of GLT-1 in nucleus accumbens of male alcohol-preferring rats. | Das SC et al. | โ | 2015 | โ |
| Chronic cocaine disrupts mesocortical learning mechanisms. | Buchta WC et al. | โ | 2015 | โ |
| Co-administration of ethanol and nicotine: the enduring alterations in the rewarding properties of nicotine and glutamate activity within the mesocorticolimbic system of female alcohol-preferring (P) rats. | Deehan GA et al. | โ | 2015 | โ |
| Cocaine-induced suppression of saccharin intake and morphine modulation of Caยฒโบ channel currents in sensory neurons of OPRM1 A118G mice. | Freet CS et al. | โ | 2015 | โ |
| DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons. | Engmann O et al. | โ | 2015 | โ |
| Deep TMS on alcoholics: effects on cortisolemia and dopamine pathway modulation. A pilot study. | Ceccanti M et al. | โ | 2015 | โ |
| Dorsal medial prefrontal cortex (MPFC) circuitry in rodent models of cocaine use: implications for drug addiction therapies. | Jasinska AJ et al. | โ | 2015 | โ |
| Editorial: structural plasticity induced by drugs of abuse. | Olive MF et al. | โ | 2015 | โ |
| Effects of prenatal immune activation on amphetamine-induced addictive behaviors: Contributions from animal models. | Borรงoi AR et al. | โ | 2015 | โ |
| Elevation of BDNF exon I-specific transcripts in the frontal cortex and midbrain of rat during spontaneous morphine withdrawal is accompanied by enhanced pCreb1 occupancy at the corresponding promoter. | Peregud DI et al. | โ | 2015 | โ |
| Food reward system: current perspectives and future research needs. | Alonso-Alonso M et al. | โ | 2015 | โ |
| Neuroplasticity and Predictors of Alcohol Recovery. | Seo D et al. | โ | 2015 | โ |
| Neuroscience of Internet Pornography Addiction: A Review and Update. | Love T et al. | โ | 2015 | โ |
| Noninvasive brain stimulation to suppress craving in substance use disorders: Review of human evidence and methodological considerations for future work. | Hone-Blanchet A et al. | โ | 2015 | โ |
| Orexin-1 receptor signaling increases motivation for cocaine-associated cues. | Bentzley BS et al. | โ | 2015 | โ |
| Repeated cycles of chronic intermittent ethanol exposure increases basal glutamate in the nucleus accumbens of mice without affecting glutamate transport. | Griffin WC et al. | โ | 2015 | โ |
| Single prolonged stress effects on sensitization to cocaine and cocaine self-administration in rats. | Eagle AL et al. | โ | 2015 | โ |
| The HIV-1 transgenic rat model of neuroHIV. | Vigorito M et al. | โ | 2015 | โ |
| Thyroid receptor ฮฒ involvement in the effects of acute nicotine on hippocampus-dependent memory. | Leach PT et al. | โ | 2015 | โ |
| Transcranial direct current stimulation in psychiatric disorders. | Tortella G et al. | โ | 2015 | โ |
| Abstinence from cocaine and sucrose self-administration reveals altered mesocorticolimbic circuit connectivity by resting state MRI. | Lu H et al. | โ | 2014 | โ |
| Addicted to palatable foods: comparing the neurobiology of Bulimia Nervosa to that of drug addiction. | Hadad NA et al. | โ | 2014 | โ |
| Age-dependent alterations in reward-seeking behavior after brief nicotine exposure. | Mojica CY et al. | โ | 2014 | โ |
| Alcohol use disorder: pathophysiology, effects, and pharmacologic options for treatment. | Wackernah RC et al. | โ | 2014 | โ |
| Brain proton magnetic resonance spectroscopy of alcohol use disorders. | Meyerhoff DJ | โ | 2014 | โ |
| Chronic cocaine effects in retinal metabolism and electrophysiology: treatment with topiramate. | Sรกnchez-Villarejo MV et al. | โ | 2014 | โ |
| Cocaine-induced changes in NMDA receptor signaling. | Ortinski PI | โ | 2014 | โ |
| Critical role of peripheral drug actions in experience-dependent changes in nucleus accumbens glutamate release induced by intravenous cocaine. | Wakabayashi KT et al. | โ | 2014 | โ |
| Dopamine D1 and D3 receptors mediate reconsolidation of cocaine memories in mouse models of drug self-administration. | Yan Y et al. | โ | 2014 | โ |
| Economic demand predicts addiction-like behavior and therapeutic efficacy of oxytocin in the rat. | Bentzley BS et al. | โ | 2014 | โ |
| Elevated BDNF mRNA expression in the medial prefrontal cortex after d-amphetamine reinstated conditioned place preference in rats. | Shen YL et al. | โ | 2014 | โ |
| Epigenetics, microRNA, and addiction. | Kenny PJ | โ | 2014 | โ |
| Factors modulating neural reactivity to drug cues in addiction: a survey of human neuroimaging studies. | Jasinska AJ et al. | โ | 2014 | โ |
| Food restriction increases long-term memory persistence in adult or aged mice. | Talhati F et al. | โ | 2014 | โ |
| Functional consequences of cocaine re-exposure after discontinuation of cocaine availability. | Beveridge TJ et al. | โ | 2014 | โ |
| Illicit dopamine transients: reconciling actions of abused drugs. | Covey DP et al. | โ | 2014 | โ |
| Mechanisms of metabonomic for a gateway drug: nicotine priming enhances behavioral response to cocaine with modification in energy metabolism and neurotransmitter level. | Li H et al. | โ | 2014 | โ |
| Methadone maintenance patients show a selective deficit to reverse positive outcomes in drug-related conditions compared to medication free prolonged opiate abstinence. | Levy-Gigi E et al. | โ | 2014 | โ |
| Modulation of risky choices in recently abstinent dependent cocaine users: a transcranial direct-current stimulation study. | Gorini A et al. | โ | 2014 | โ |
| NCAM signaling mediates the effects of GDNF on chronic morphine-induced neuroadaptations. | Li L et al. | โ | 2014 | โ |
| Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction. | George O et al. | โ | 2014 | โ |
| Neural correlates of reward-based spatial learning in persons with cocaine dependence. | Tau GZ et al. | โ | 2014 | โ |
| Neural ECM in addiction, schizophrenia, and mood disorder. | Lubbers BR et al. | โ | 2014 | โ |
| Neuronal extracellular signal-regulated kinase (ERK) activity as marker and mediator of alcohol and opioid dependence. | Zamora-Martinez ER et al. | โ | 2014 | โ |
| Open label smoking cessation with varenicline is associated with decreased glutamate levels and functional changes in anterior cingulate cortex: preliminary findings. | Wheelock MD et al. | โ | 2014 | โ |
| Optogenetic dissection of medial prefrontal cortex circuitry. | Riga D et al. | โ | 2014 | โ |
| Orbitofrontal activation restores insight lost after cocaine use. | Lucantonio F et al. | โ | 2014 | โ |
| Pharmacological approaches to reducing craving in patients with alcohol use disorders. | Haass-Koffler CL et al. | โ | 2014 | โ |
| Regional expression of extracellular signal-regulated kinase 1 and 2 mRNA in a morphine-induced conditioned place preference model. | Yuan Ma J et al. | โ | 2014 | โ |
| Role of glutathione, glutathione transferase, and glutaredoxin in regulation of redox-dependent processes. | Kalinina EV et al. | โ | 2014 | โ |
| rTMS in the treatment of drug addiction: an update about human studies. | Bellamoli E et al. | โ | 2014 | โ |
| Short-term abstinence from cocaine self-administration, but not passive cocaine infusion, elevates ฮฑCaMKII autophosphorylation in the rat nucleus accumbens and medial prefrontal cortex. | Caffino L et al. | โ | 2014 | โ |
| Structural plasticity in mesencephalic dopaminergic neurons produced by drugs of abuse: critical role of BDNF and dopamine. | Collo G et al. | โ | 2014 | โ |
| Synapse density and dendritic complexity are reduced in the prefrontal cortex following seven days of forced abstinence from cocaine self-administration. | Rasakham K et al. | โ | 2014 | โ |
| Targeting midkine and pleiotrophin signalling pathways in addiction and neurodegenerative disorders: recent progress and perspectives. | Herradรณn G et al. | โ | 2014 | โ |
| Targeting the glutamatergic system to treat pathological gambling: current evidence and future perspectives. | Pettorruso M et al. | โ | 2014 | โ |
| The effect of active and passive intravenous cocaine administration on the extracellular signal-regulated kinase (ERK) activity in the rat brain. | Miszkiel J et al. | โ | 2014 | โ |
| Acute ketamine-induced neuroplasticity: ribosomal protein S6 phosphorylation expression in drug addiction-related rat brain areas. | Tedesco V et al. | โ | 2013 | โ |
| Adult hippocampal neurogenesis in the pathogenesis of addiction and dual diagnosis disorders. | Chambers RA | โ | 2013 | โ |
| Advances in genetic studies of substance abuse in China. | Sun Y et al. | โ | 2013 | โ |
| Animal studies of addictive behavior. | Vanderschuren LJ et al. | โ | 2013 | โ |
| Are AMPA receptor positive allosteric modulators potential pharmacotherapeutics for addiction? | Watterson LR et al. | โ | 2013 | โ |
| Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness. | Berk M et al. | โ | 2013 | โ |
| Behavioral daily rhythmic activity pattern of adolescent female rat is modulated by acute and chronic cocaine. | Lee MJ et al. | โ | 2013 | โ |
| Brain-derived neurotrophic factor-estrogen interactions in the hippocampal mossy fiber pathway: implications for normal brain function and disease. | Harte-Hargrove LC et al. | โ | 2013 | โ |
| Cellular basis of memory for addiction. | Nestler EJ | โ | 2013 | โ |
| Chronic alcohol produces neuroadaptations to prime dorsal striatal learning. | DePoy L et al. | โ | 2013 | โ |
| Chronic cigarette smoking in alcohol dependence: associations with cortical thickness and N-acetylaspartate levels in the extended brain reward system. | Durazzo TC et al. | โ | 2013 | โ |
| Deficits in ventromedial prefrontal cortex group 1 metabotropic glutamate receptor function mediate resistance to extinction during protracted withdrawal from an extensive history of cocaine self-administration. | Ben-Shahar O et al. | โ | 2013 | โ |
| Differential striatal spine pathology in Parkinson's disease and cocaine addiction: a key role of dopamine? | Villalba RM et al. | โ | 2013 | โ |
| Disorders of memory and plasticity in psychiatric disease. | Pittenger C | โ | 2013 | โ |
| Drug-evoked synaptic plasticity causing addictive behavior. | Lรผscher C | โ | 2013 | โ |
| Effects of risperidone on the acquisition and reinstatement of the conditioned place preference induced by MDMA. | Roger-Sรกnchez C et al. | โ | 2013 | โ |
| Epigenetics and early life origins of chronic noncommunicable diseases. | Wang G et al. | โ | 2013 | โ |
| Extracellular signal-regulated kinase in the basolateral amygdala, but not the nucleus accumbens core, is critical for context-response-cocaine memory reconsolidation in rats. | Wells AM et al. | โ | 2013 | โ |
| Functional neuroimaging studies of alcohol cue reactivity: a quantitative meta-analysis and systematic review. | Schacht JP et al. | โ | 2013 | โ |
| Genetic differences in the modulation of accumbal glutamate and ฮณ-amino butyric acid levels after cocaine-induced reinstatement. | Miguรฉns M et al. | โ | 2013 | โ |
| Genetic influences on craving for alcohol. | Agrawal A et al. | โ | 2013 | โ |
| Glutamatergic targets for new alcohol medications. | Holmes A et al. | โ | 2013 | โ |
| Involvement of 5-hydroxytryptamine 5-HTโ serotonergic receptors in the acquisition and reinstatement of the conditioned place preference induced by MDMA. | Roger-Sรกnchez C et al. | โ | 2013 | โ |
| Long-term effects of cocaine experience on neuroplasticity in the nucleus accumbens core of addiction-prone rats. | Waselus M et al. | โ | 2013 | โ |
| Neurobiology of addiction versus drug use driven by lack of choice. | Ahmed SH et al. | โ | 2013 | โ |
| Neuroplasticity, axonal guidance and micro-RNA genes are associated with morphine self-administration behavior. | Tapocik JD et al. | โ | 2013 | โ |
| Pharmacotherapy of amphetamine-type stimulant dependence: an update. | Brensilver M et al. | โ | 2013 | โ |
| Positive association between--1021TT genotype of dopamine beta hydroxylase gene and progressive behavior of injection heroin users. | Xie X et al. | โ | 2013 | โ |
| Prospective associations between brain activation to cocaine and no-go cues and cocaine relapse. | Prisciandaro JJ et al. | โ | 2013 | โ |
| Regulation of extinction of cocaine-induced place preference by midkine is related to a differential phosphorylation of peroxiredoxin 6 in dorsal striatum. | Gramage E et al. | โ | 2013 | โ |
| Repeated cocaine weakens GABA(B)-Girk signaling in layer 5/6 pyramidal neurons in the prelimbic cortex. | Hearing M et al. | โ | 2013 | โ |
| Role of nucleus accumbens glutamatergic plasticity in drug addiction. | Quintero GC | โ | 2013 | โ |
| Roles of levo-tetrahydropalmatine in modulating methamphetamine reward behavior. | Su HL et al. | โ | 2013 | โ |
| THC reduces the anticipatory nucleus accumbens response to reward in subjects with a nicotine addiction. | Jansma JM et al. | โ | 2013 | โ |
| The contribution of brain reward circuits to the obesity epidemic. | Stice E et al. | โ | 2013 | โ |
| The differential effects of OX1R and OX2R selective antagonists on morphine conditioned place preference in naรฏve versus morphine-dependent mice. | Tabaeizadeh M et al. | โ | 2013 | โ |
| The downward spiral of chronic pain, prescription opioid misuse, and addiction: cognitive, affective, and neuropsychopharmacologic pathways. | Garland EL et al. | โ | 2013 | โ |
| The effects of cocaine on different redox forms of cysteine and homocysteine, and on labile, reduced sulfur in the rat plasma following active versus passive drug injections. | Kowalczyk-Pachel D et al. | โ | 2013 | โ |
| The metabotropic glutamate 5 receptor modulates extinction and reinstatement of methamphetamine-seeking in mice. | Chesworth R et al. | โ | 2013 | โ |
| The neurocircuitry of illicit psychostimulant addiction: acute and chronic effects in humans. | Taylor SB et al. | โ | 2013 | โ |
| The "stop" and "go" of nicotine dependence: role of GABA and glutamate. | D'Souza MS et al. | โ | 2013 | โ |
| The synaptic adhesion molecule SynCAM 1 contributes to cocaine effects on synapse structure and psychostimulant behavior. | Giza JI et al. | โ | 2013 | โ |
| Varenicline and neuronal nicotinic acetylcholine receptors: a new approach to the treatment of co-occurring alcohol and nicotine addiction? | Nocente R et al. | โ | 2013 | โ |
| Whole brain and brain regional coexpression network interactions associated with predisposition to alcohol consumption. | Vanderlinden LA et al. | โ | 2013 | โ |
| (-)-2-oxa-4-aminobicylco[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) and 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine (MTEP) similarly attenuate stress-induced reinstatement of cocaine seeking. | Martin-Fardon R et al. | โ | 2012 | โ |
| Actin dynamics in development of behavioral sensitization after withdrawal from long-term ethanol administration to mice. | Shibasaki M et al. | โ | 2012 | โ |
| Analyses related to the development of DSM-5 criteria for substance use related disorders: 2. Proposed DSM-5 criteria for alcohol, cannabis, cocaine and heroin disorders in 663 substance abuse patients. | Hasin DS et al. | โ | 2012 | โ |
| An emerging role for the Mammalian target of rapamycin in "pathological" protein translation: relevance to cocaine addiction. | Dayas CV et al. | โ | 2012 | โ |
| Behavioral addictions: an overview. | Karim R et al. | โ | 2012 | โ |
| Brain regions associated with the acquisition of conditioned place preference for cocaine vs. social interaction. | El Rawas R et al. | โ | 2012 | โ |
| Brain region-specific gene expression changes after chronic intermittent ethanol exposure and early withdrawal in C57BL/6J mice. | Melendez RI et al. | โ | 2012 | โ |
| Candidate pathway association study in cocaine dependence: the control of neurotransmitter release. | Fernร ndez-Castillo N et al. | โ | 2012 | โ |
| CM156, a sigma receptor ligand, reverses cocaine-induced place conditioning and transcriptional responses in the brain. | Xu YT et al. | โ | 2012 | โ |
| Cocaine-induced adaptations in metabotropic inhibitory signaling in the mesocorticolimbic system. | Hearing MC et al. | โ | 2012 | โ |
| Compulsive drug use and its neural substrates. | Lesscher HM et al. | โ | 2012 | โ |
| CREB1 and CREB-binding protein in striatal medium spiny neurons regulate behavioural responses to psychostimulants. | Madsen HB et al. | โ | 2012 | โ |
| Differences in rat dorsal striatal NMDA and AMPA receptors following acute and repeated cocaine-induced locomotor activation. | Yamamoto DJ et al. | โ | 2012 | โ |
| Distinct roles of dopamine D3 receptors in modulating methamphetamine-induced behavioral sensitization and ultrastructural plasticity in the shell of the nucleus accumbens. | Zhu J et al. | โ | 2012 | โ |
| [Drug dependence: Progress in neurobiology and perspectives in therapeutics]. | Marie N et al. | โ | 2012 | โ |
| Drug specificity in extended access cocaine and heroin self-administration. | Lenoir M et al. | โ | 2012 | โ |
| Dynamic changes of tyrosine hydroxylase and dopamine concentrations in the ventral tegmental area-nucleus accumbens projection during the expression of morphine-induced conditioned place preference in rats. | Liang J et al. | โ | 2012 | โ |
| Effects of prenatal immune activation and peri-adolescent stress on amphetamine-induced conditioned place preference in the rat. | Richtand NM et al. | โ | 2012 | โ |
| Emotional valence and context of social influences on drug abuse-related behavior in animal models of social stress and prosocial interaction. | Neisewander JL et al. | โ | 2012 | โ |
| Enhanced anxiety observed in cocaine withdrawn rats is associated with altered reactivity of the dorsomedial prefrontal cortex. | El Hage C et al. | โ | 2012 | โ |
| Enhanced extinction of cocaine seeking in brain-derived neurotrophic factor Val66Met knock-in mice. | Briand LA et al. | โ | 2012 | โ |
| Escalation of cocaine intake with extended access in rats: dysregulated addiction or regulated acquisition? | Beckmann JS et al. | โ | 2012 | โ |
| Ethanol-mediated facilitation of AMPA receptor function in the dorsomedial striatum: implications for alcohol drinking behavior. | Wang J et al. | โ | 2012 | โ |
| Facilitated extinction of morphine conditioned place preference with Tat-GluA2(3Y) interference peptide. | Dias C et al. | โ | 2012 | โ |
| Feed-forward mechanisms: addiction-like behavioral and molecular adaptations in overeating. | Alsiรถ J et al. | โ | 2012 | โ |
| Food restriction increases acquisition, persistence and drug prime-induced expression of a cocaine-conditioned place preference in rats. | Zheng D et al. | โ | 2012 | โ |
| GABA system changes in methylphenidate sensitized female rats. | Freese L et al. | โ | 2012 | โ |
| Glutamate, GABA, and other cortical metabolite concentrations during early abstinence from alcohol and their associations with neurocognitive changes. | Mon A et al. | โ | 2012 | โ |
| Histamine and motivation. | Torrealba F et al. | โ | 2012 | โ |
| Identification and management of pain medication abuse and misuse: current state and future directions. | Hartrick CT et al. | โ | 2012 | โ |
| Linking ADHD, impulsivity, and drug abuse: a neuropsychological perspective. | Urcelay GP et al. | โ | 2012 | โ |
| Neurobiological correlates of illness progression in the recurrent affective disorders. | Post RM et al. | โ | 2012 | โ |
| Neuroplasticity in addiction: cellular and transcriptional perspectives. | Madsen HB et al. | โ | 2012 | โ |
| Orexin/hypocretin (Orx/Hcrt) transmission and drug-seeking behavior: is the paraventricular nucleus of the thalamus (PVT) part of the drug seeking circuitry? | Martin-Fardon R et al. | โ | 2012 | โ |
| Pharmacotherapeutics directed at deficiencies associated with cocaine dependence: focus on dopamine, norepinephrine and glutamate. | Haile CN et al. | โ | 2012 | โ |
| Protracted manifestations of acute dependence after a single morphine exposure. | Rothwell PE et al. | โ | 2012 | โ |
| Reduced grey matter in the posterior insula as a structural vulnerability or diathesis to addiction. | Gardini S et al. | โ | 2012 | โ |
| Temporally dependent changes in cocaine-induced synaptic plasticity in the nucleus accumbens shell are reversed by D1-like dopamine receptor stimulation. | Ortinski PI et al. | โ | 2012 | โ |
| The impact of orbitofrontal dysfunction on cocaine addiction. | Lucantonio F et al. | โ | 2012 | โ |
| The MTHFR C677T Variant is Associated with Responsiveness to Disulfiram Treatment for Cocaine Dependency. | Spellicy CJ et al. | โ | 2012 | โ |
| Thorndike's Law 2.0: Dopamine and the Regulation of Thrift. | Beeler JA | โ | 2012 | โ |
| Activation of dopamine D3 receptors inhibits reward-related learning induced by cocaine. | Kong H et al. | โ | 2011 | โ |
| Acute blockade of CB1 receptor leads to reinstatement of MDMA-induced conditioned place preference. | Daza-Losada M et al. | โ | 2011 | โ |
| Acute cocaine increases interleukin-1ฮฒ mRNA and immunoreactive cells in the cortex and nucleus accumbens. | Cearley CN et al. | โ | 2011 | โ |
| A high fructose diet does not affect amphetamine self-administration or spatial water maze learning and memory in female rats. | Bruggeman EC et al. | โ | 2011 | โ |
| Alcohol craving and the dimensionality of alcohol disorders. | Keyes KM et al. | โ | 2011 | โ |
| Alcohol-preferring (P) rats are more sensitive than Wistar rats to the reinforcing effects of cocaine self-administered directly into the nucleus accumbens shell. | Katner SN et al. | โ | 2011 | โ |
| A novel role for PSD-95 in mediating ethanol intoxication, drinking and place preference. | Camp MC et al. | โ | 2011 | โ |
| Brain-derived neurotrophic factor serum levels in alcohol-dependent subjects 6 months after alcohol withdrawal. | Costa MA et al. | โ | 2011 | โ |
| Brain morphology at entry into treatment for alcohol dependence is related to relapse propensity. | Cardenas VA et al. | โ | 2011 | โ |
| Cocaine-induced adaptations in cellular redox balance contributes to enduring behavioral plasticity. | Uys JD et al. | โ | 2011 | โ |
| Cognitive enhancers in the treatment of substance use disorders: clinical evidence. | Brady KT et al. | โ | 2011 | โ |
| Correlation of rat cortical Fas-associated death domain (FADD) protein phosphorylation with the severity of spontaneous morphine abstinence syndrome: role of ฮฑ(2)-adrenoceptors and extracellular signal-regulated kinases. | Ramos-Miguel A et al. | โ | 2011 | โ |
| Cortical thickness, surface area, and volume of the brain reward system in alcohol dependence: relationships to relapse and extended abstinence. | Durazzo TC et al. | โ | 2011 | โ |
| Down-regulated striatal gene expression for synaptic plasticity-associated proteins in addiction and relapse vulnerable animals. | Brown AL et al. | โ | 2011 | โ |
| Drug-evoked synaptic plasticity in addiction: from molecular changes to circuit remodeling. | Lรผscher C et al. | โ | 2011 | โ |
| Drugs and addiction: an introduction to epigenetics. | Wong CC et al. | โ | 2011 | โ |
| Effects of CNQX and MPEP on sensitization to the rewarding effects of morphine. | Manzanedo C et al. | โ | 2011 | โ |
| Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors. | Serrano A et al. | โ | 2011 | โ |
| Endocannabinoid-mediated synaptic plasticity and addiction-related behavior. | Sidhpura N et al. | โ | 2011 | โ |
| Enhanced cue reactivity and fronto-striatal functional connectivity in cocaine use disorders. | Wilcox CE et al. | โ | 2011 | โ |
| Ethanol-induced changes in the expression of proteins related to neurotransmission and metabolism in different regions of the rat brain. | Zahr NM et al. | โ | 2011 | โ |
| Exploring mechanisms underlying extinction of cue-elicited cocaine seeking. | Kong H et al. | โ | 2011 | โ |
| Food scarcity, neuroadaptations, and the pathogenic potential of dieting in an unnatural ecology: binge eating and drug abuse. | Carr KD | โ | 2011 | โ |
| Glutamatergic neuroplasticity in cocaine addiction. | Uys JD et al. | โ | 2011 | โ |
| Group II metabotropic glutamate receptors in the striatum of non-human primates: dysregulation following chronic cocaine self-administration. | Beveridge TJ et al. | โ | 2011 | โ |
| Hooked on benzodiazepines: GABAA receptor subtypes and addiction. | Tan KR et al. | โ | 2011 | โ |
| Induction of innate immune genes in brain create the neurobiology of addiction. | Crews FT et al. | โ | 2011 | โ |
| Natural rewards, neuroplasticity, and non-drug addictions. | Olsen CM | โ | 2011 | โ |
| Neuroimaging and drug taking in primates. | Murnane KS et al. | โ | 2011 | โ |
| Neuronal mechanisms underlying development of nicotine dependence: implications for novel smoking-cessation treatments. | D'Souza MS et al. | โ | 2011 | โ |
| Playing video games while using or feeling the effects of substances: associations with substance use problems. | Ream GL et al. | โ | 2011 | โ |
| Projection-specific modulation of dopamine neuron synapses by aversive and rewarding stimuli. | Lammel S et al. | โ | 2011 | โ |
| Propensity to 'relapse' following exposure to cocaine cues is associated with the recruitment of specific thalamic and epithalamic nuclei. | James MH et al. | โ | 2011 | โ |
| Regulation of MiR-124, Let-7d, and MiR-181a in the accumbens affects the expression, extinction, and reinstatement of cocaine-induced conditioned place preference. | Chandrasekar V et al. | โ | 2011 | โ |
| Role of actin depolymerizing factor in the development of methamphetamine-induced place preference in mice. | Shibasaki M et al. | โ | 2011 | โ |
| Striatal signal transduction and drug addiction. | Philibin SD et al. | โ | 2011 | โ |
| The interactive effects of environmental enrichment and extinction interventions in attenuating cue-elicited cocaine-seeking behavior in rats. | Thiel KJ et al. | โ | 2011 | โ |
| The mGluR5 Positive Allosteric Modulator CDPPB Does Not Alter Extinction or Contextual Reinstatement of Methamphetamine-Seeking Behavior in Rats. | Widholm JJ et al. | โ | 2011 | โ |
| Understanding and treating opioid addiction in a patient with cancer pain. | Kircher S et al. | โ | 2011 | โ |
| Water-soluble coenzyme Q10 formulation in presbycusis: long-term effects. | Guastini L et al. | โ | 2011 | โ |
| 5-HT1A receptors mediate detrimental effects of cocaine on long-term potentiation and expression of polysialylated neural cell adhesion molecule protein in rat dentate gyrus. | Grzegorzewska M et al. | โ | 2010 | โ |
| Activators of G-protein signaling 3: a drug addiction molecular gateway. | Bowers MS | โ | 2010 | โ |
| Addiction related alteration in resting-state brain connectivity. | Ma N et al. | โ | 2010 | โ |
| Adolescent social defeat alters neural, endocrine and behavioral responses to amphetamine in adult male rats. | Burke AR et al. | โ | 2010 | โ |
| AMPA receptor synaptic plasticity induced by psychostimulants: the past, present, and therapeutic future. | Bowers MS et al. | โ | 2010 | โ |
| A novel substituted piperazine, CM156, attenuates the stimulant and toxic effects of cocaine in mice. | Xu YT et al. | โ | 2010 | โ |
| A placebo-controlled trial of memantine for cocaine dependence with high-value voucher incentives during a pre-randomization lead-in period. | Bisaga A et al. | โ | 2010 | โ |
| beta-Arrestin 2-mediated heterologous desensitization of IGF-IR by prolonged exposure of SH-SY5Y neuroblastoma cells to a mu opioid agonist. | Spartร A et al. | โ | 2010 | โ |
| Brain stimulation in the study and treatment of addiction. | Feil J et al. | โ | 2010 | โ |
| Chronic cigarette smoking: implications for neurocognition and brain neurobiology. | Durazzo TC et al. | โ | 2010 | โ |
| Cocaine deprivation effect: cue abstinence over weekends boosts anticipatory 50-kHz ultrasonic vocalizations in rats. | Maier EY et al. | โ | 2010 | โ |
| Cocaine-induced neuroadaptations in glutamate transmission: potential therapeutic targets for craving and addiction. | Schmidt HD et al. | โ | 2010 | โ |
| Cocaine-mediated synaptic potentiation is absent in VTA neurons from mGlu5-deficient mice. | Bird MK et al. | โ | 2010 | โ |
| Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction. | Olive MF | โ | 2010 | โ |
| Cortical perfusion in alcohol-dependent individuals during short-term abstinence: relationships to resumption of hazardous drinking after treatment. | Durazzo TC et al. | โ | 2010 | โ |
| Craving's place in addiction theory: contributions of the major models. | Skinner MD et al. | โ | 2010 | โ |
| Dopamine D1 and D3 receptors are differentially involved in cue-elicited cocaine seeking. | Chen L et al. | โ | 2010 | โ |
| Dopamine D1 and N-methyl-D-aspartate receptors and extracellular signal-regulated kinase mediate neuronal morphological changes induced by repeated cocaine administration. | Ren Z et al. | โ | 2010 | โ |
| Episodic withdrawal promotes psychomotor sensitization to morphine. | Rothwell PE et al. | โ | 2010 | โ |
| Glutamatergic targets for enhancing extinction learning in drug addiction. | Cleva RM et al. | โ | 2010 | โ |
| Group II metabotropic glutamate receptors (mGlu2/3) in drug addiction. | Moussawi K et al. | โ | 2010 | โ |
| Individual differences in nucleus accumbens dopamine receptors predict development of addiction-like behavior: a computational approach. | Piray P et al. | โ | 2010 | โ |
| Inflexible and indifferent alcohol drinking in male mice. | Lesscher HM et al. | โ | 2010 | โ |
| Matrix-assisted laser desorption/ionization tissue profiling of secretoneurin in the nucleus accumbens shell from cocaine-sensitized rats. | Uys JD et al. | โ | 2010 | โ |
| Measuring addiction propensity and severity: the need for a new instrument. | Conway KP et al. | โ | 2010 | โ |
| Mechanisms of illness progression in the recurrent affective disorders. | Post RM | โ | 2010 | โ |
| Metabolite levels in the brain reward pathway discriminate those who remain abstinent from those who resume hazardous alcohol consumption after treatment for alcohol dependence. | Durazzo TC et al. | โ | 2010 | โ |
| Neurocircuitry of addiction. | Koob GF et al. | โ | 2010 | โ |
| Prefrontal cortical regulation of drug seeking in animal models of drug relapse. | Lasseter HC et al. | โ | 2010 | โ |
| Repeated intravenous cocaine experience: development and escalation of pre-drug anticipatory 50-kHz ultrasonic vocalizations in rats. | Ma ST et al. | โ | 2010 | โ |
| Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances. | Brower KJ et al. | โ | 2010 | โ |
| Striatal microRNA controls cocaine intake through CREB signalling. | Hollander JA et al. | โ | 2010 | โ |
| The brain-specific Neural Zinc Finger transcription factor 2b (NZF-2b/7ZFMyt1) causes suppression of cocaine-induced locomotor activity. | Chandrasekar V et al. | โ | 2010 | โ |
| The Brain-Specific Neural Zinc Finger Transcription Factor 2b (NZF-2b/7ZFMyt1) Suppresses Cocaine Self-Administration in Rats. | Chandrasekar V et al. | โ | 2010 | โ |
| The emergence of gonadal hormone influences on dopaminergic function during puberty. | Kuhn C et al. | โ | 2010 | โ |
| Ventral and dorsal striatal dopamine efflux and behavior in rats with simple vs. co-morbid histories of cocaine sensitization and neonatal ventral hippocampal lesions. | Chambers RA et al. | โ | 2010 | โ |
| Viral-mediated expression of extracellular signal-regulated kinase-2 in the ventral tegmental area modulates behavioral responses to cocaine. | Iรฑiguez SD et al. | โ | 2010 | โ |
| Water-soluble coenzyme Q10 formulation (Q-TER(ยฎ)) in the treatment of presbycusis. | Salami A et al. | โ | 2010 | โ |
| Altered dendritic spine plasticity in cocaine-withdrawn rats. | Shen HW et al. | โ | 2009 | โ |
| A neurocomputational model for cocaine addiction. | Dezfouli A et al. | โ | 2009 | โ |
| Anti-relapse medications: preclinical models for drug addiction treatment. | Yahyavi-Firouz-Abadi N et al. | โ | 2009 | โ |
| Are adolescents more vulnerable to drug addiction than adults? Evidence from animal models. | Schramm-Sapyta NL et al. | โ | 2009 | โ |
| A role for the circadian genes in drug addiction. | Falcรณn E et al. | โ | 2009 | โ |
| Association analysis between polymorphisms in the conserved dopamine neurotrophic factor (CDNF) gene and cocaine dependence. | Lohoff FW et al. | โ | 2009 | โ |
| Association of nicotine addiction and nicotine's actions with separate cingulate cortex functional circuits. | Hong LE et al. | โ | 2009 | โ |
| Attenuated incubation of cocaine seeking in male rats trained to self-administer cocaine during periadolescence. | Li C et al. | โ | 2009 | โ |
| Different effects on dopamine release in nucleus accumbens in mice by the morphine metabolites morphine-6-glucuronide and morphine-3-glucuronide. | Vindenes V et al. | โ | 2009 | โ |
| Dorsal hippocampal regulation of memory reconsolidation processes that facilitate drug context-induced cocaine-seeking behavior in rats. | Ramirez DR et al. | โ | 2009 | โ |
| Drosophila, a genetic model system to study cocaine-related behaviors: a review with focus on LIM-only proteins. | Heberlein U et al. | โ | 2009 | โ |
| Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory. | Koob GF | โ | 2009 | โ |
| Effect of rapamycin on cue-induced drug craving in abstinent heroin addicts. | Shi J et al. | โ | 2009 | โ |
| Effects of N-acetylcysteine on substance use in bipolar disorder: a randomised placebo-controlled clinical trial. | Bernardo M et al. | โ | 2009 | โ |
| Effects of N-acetylcysteine on substance use in bipolar disorder: A randomised placebo-controlled clinical trial. | Bernardo M et al. | โ | 2009 | โ |
| Elevated cortisol and learning and memory deficits in cocaine dependent individuals: relationship to relapse outcomes. | Fox HC et al. | โ | 2009 | โ |
| Epigenetic mechanisms underlying extinction of memory and drug-seeking behavior. | Malvaez M et al. | โ | 2009 | โ |
| Extinction of morphine-dependent conditioned behavior is associated with increased phosphorylation of the GluR1 subunit of AMPA receptors at hippocampal synapses. | Billa SK et al. | โ | 2009 | โ |
| Genetical genomic determinants of alcohol consumption in rats and humans. | Tabakoff B et al. | โ | 2009 | โ |
| Glutamate transmission in addiction. | Kalivas PW et al. | โ | 2009 | โ |
| Memantine blocks sensitization to the rewarding effects of morphine. | Aguilar MA et al. | โ | 2009 | โ |
| Methamphetamine Dysregulates Redox Status in Primary Rat Astrocyte and Mesencephalic Neuronal Cultures. | Ali SF et al. | โ | 2009 | โ |
| Methylphenidate-induced dendritic spine formation and DeltaFosB expression in nucleus accumbens. | Kim Y et al. | โ | 2009 | โ |
| Molecular mechanisms of psychostimulant-induced structural plasticity. | Dietz DM et al. | โ | 2009 | โ |
| N-Acetylcysteine reverses cocaine-induced metaplasticity. | Moussawi K et al. | โ | 2009 | โ |
| Narp deletion blocks extinction of morphine place preference conditioning. | Crombag HS et al. | โ | 2009 | โ |
| Neuronal pentraxins modulate cocaine-induced neuroadaptations. | Pacchioni AM et al. | โ | 2009 | โ |
| Neurotrophic factors and structural plasticity in addiction. | Russo SJ et al. | โ | 2009 | โ |
| Phosphorylation of FADD (Fas-associated death domain protein) at serine 194 is increased in the prefrontal cortex of opiate abusers: relation to mitogen activated protein kinase, phosphoprotein enriched in astrocytes of 15 kDa, and Akt signaling pathways involved in neuroplasticity. | Ramos-Miguel A et al. | โ | 2009 | โ |
| Single session of cocaine intravenous self-administration shapes goal-oriented behaviours and up-regulates Arc mRNA levels in rat medial prefrontal cortex. | Fumagalli F et al. | โ | 2009 | โ |
| Strain differences between Lewis and Fischer 344 rats in the modulation of dopaminergic receptors after morphine self-administration and during extinction. | Sรกnchez-Cardoso P et al. | โ | 2009 | โ |
| Targeting extinction and reconsolidation mechanisms to combat the impact of drug cues on addiction. | Taylor JR et al. | โ | 2009 | โ |
| The glutamate homeostasis hypothesis of addiction. | Kalivas PW | โ | 2009 | โ |
| The neurobiology of addictive disorders. | Ross S et al. | โ | 2009 | โ |
| The promiscuous mGlu5 receptor--a range of partners for therapeutic possibilities? | Bird MK et al. | โ | 2009 | โ |
| The regulation of neuronal gene expression by alcohol. | Pignataro L et al. | โ | 2009 | โ |
| The Role of AMPAR Trafficking Mediated by Neuronal Pentraxins in Cocaine-induced Neuroadaptations. | Pacchioni AM et al. | โ | 2009 | โ |
| The role of glutamate and its receptors in mesocorticolimbic dopaminergic regions in opioid addiction. | Guo Y et al. | โ | 2009 | โ |
| WITHDRAWN: Anti-relapse medications: Preclinical models for drug addiction treatment. | Yahyavi-Firouz-Abadi N et al. | โ | 2009 | โ |
| Addiction as a pathology in prefrontal cortical regulation of corticostriatal habit circuitry. | Kalivas PW | โ | 2008 | โ |
| Affective status in relation to impulsive, motor and motivational symptoms: personality, development and physical exercise. | Palomo T et al. | โ | 2008 | โ |
| Dual dopamine/serotonin releasers: potential treatment agents for stimulant addiction. | Rothman RB et al. | โ | 2008 | โ |
| Elevated synaptophysin I in the prefrontal cortex of human chronic alcoholics. | Henriksson R et al. | โ | 2008 | โ |
| Fos regulates neuronal activity in the nucleus accumbens. | Hu XT et al. | โ | 2008 | โ |
| How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective. | Clapp P et al. | โ | 2008 | โ |
| Infralimbic prefrontal cortex is responsible for inhibiting cocaine seeking in extinguished rats. | Peters J et al. | โ | 2008 | โ |
| Interactive effects of ethanol and nicotine on learning in C57BL/6J mice depend on both dose and duration of treatment. | Gulick D et al. | โ | 2008 | โ |
| Mu-opioid receptor activation induces transcriptional plasticity in the central extended amygdala. | Befort K et al. | โ | 2008 | โ |
| N-acetylcysteine for antioxidant therapy: pharmacology and clinical utility. | Dodd S et al. | โ | 2008 | โ |
| Neuroanatomical specificity of conditioned responses to cocaine versus food in mice. | Zombeck JA et al. | โ | 2008 | โ |
| Neuropharmacology of addiction--setting the scene. | Lawrence AJ et al. | โ | 2008 | โ |
| Neuroplasticity in the mesolimbic dopamine system and cocaine addiction. | Thomas MJ et al. | โ | 2008 | โ |
| Pharmacologic mechanisms of crystal meth. | Kish SJ | โ | 2008 | โ |
| Regulation of the extrinsic and intrinsic apoptotic pathways in the prefrontal cortex of short- and long-term human opiate abusers. | Garcรญa-Fuster MJ et al. | โ | 2008 | โ |
| Reinstatement of ethanol and sucrose seeking by the neurosteroid allopregnanolone in C57BL/6 mice. | Finn DA et al. | โ | 2008 | โ |
| Review. Psychological and neural mechanisms of relapse. | Stewart J | โ | 2008 | โ |
| Review. The incentive sensitization theory of addiction: some current issues. | Robinson TE et al. | โ | 2008 | โ |
| Serotonergic mechanisms in addiction-related memories. | Nic Dhonnchadha BA et al. | โ | 2008 | โ |
| Cocaine and amphetamine-like psychostimulants: neurocircuitry and glutamate neuroplasticity. | Kalivas PW | โ | 2007 | โ |