a refined phenotype versus a loss in power due to smaller sample size. For these secondary analyses, we observed one nominally significant interaction in the opposite direction from the hypothesis (Supplemental Table S13, depression diagnosis restricted to DSM or ICD, broad stress, current depression, OR = 0.74, p = 0.01), and one nominally significant interaction in the hypothesized direction (Supplemental Table S15b), S allele coded as recessive, broad stress, lifetime depression, OR 1.25, p = 0.02). In all other analyses, the interaction term was not even nominally significant.
