For AGGoverall, a gene-based analysis was done in MAGMA [32]. The gene-based test combines P values from multiple SNPs to obtain a test statistic for each gene, while accounting for LD between the SNPs. From the MAGMA website (see URLs) we obtained (1) a list of 18 087 genes and their start- and end-positions, and (2) pre-formatted European genotypes from 1000 Genomes phase 3 for the reference LD. We applied a Bonferroni correction for multiple testing at α = 0.05/18 087. A lookup for significant results was performed in GWAS Catalog and PhenoScanner (see URLs).
