We measured the genetic overlap between PTSD and other psychiatric disorders using the most recent available datasets32,43–52. We observed moderate to high positive rg between PTSD and other psychiatric disorders (Extended Data Fig. 7a). To gain further insights into this overlap, we used MiXeR to quantify the genetic overlap in causal variation between PTSD and bipolar disorder (BPD), MDD, and schizophrenia (SCZ) (Extended Data Fig. 7b). The strong majority (79–99%) of the variation influencing PTSD risk also influenced these disorders (Extended Data Fig. 7b and Supplementary Tables 22 and 23). Similar to rg, PTSD had the highest fraction of concordant effect directions with MDD (among the shared variation) (87% concordant, s.e. = 2%), significantly higher than the directional concordance with BPD (67%, s.e. = 1%) and SCZ (65%, s.e. = 0.5%).
