Partitioned heritability across 28 functional categories identified enrichment in histone markers (H3K9ac peaks: 6.3-fold enrichment, s.e. = 1.12, P = 3.11 × 10−6; H3K4me1: 1.5-fold enrichment, s.e. = 0.14, P = 3.3 × 10−4; Supplementary Table 21), and in evolutionary constrained regions across 29 Eutherians (18.37-fold enrichment, s.e. = 1.18, P = 1.29 × 10−17). This is consistent with findings for multiple other psychiatric disorders, but has not been previously identified in PTSD42.
