Compared with the genes enriched in schizophrenia patient-derived iPSC neurons,35 nine were significantly different in bipolar vs control neurons in our study. SOX6 and FGFR3 were downregulated in both, whereas FGF14, LGALS8, PDE4D, RHOBTB3, SLC41A2, UNC5C and ZMAT4 were expressed at higher levels in schizophrenia and BP than in control neurons. Compared with an analysis of neurons differentiated from iPSC from patients with Timothy Syndrome (CACNA1C mutation37), 233 genes were expressed in a similar pattern as in BP neurons, including many transcripts involved in neuronal differentiation. Clearly, it will be important to compare our analyses with those of additional BP tissue, cell and mouse models.
