For the pooled sample, we identified two interactive models. The first consisted of two SNPs (rs3743078 and rs1317286) in CHRNA3, and the second consisted of SNPs rs621849 in CHRNA5, rs3743078 in CHRNA3, and rs11637890 in CHRNB4. However, neither model remained significant at the experiment-wide level after correction. We performed an identical interaction analysis on the EA sample, but no significant interactive model emerged.
