Regarding subjective effects during self-administration, paired-samples t-tests confirmed significantly higher scores on all subjective rating scales (AUQ, BAES stimulation/sedation, DEQ liking/wanting) immediately after priming as compared to baseline (all ps < .01). OPRM1 groups did not differ significantly on any subjective effect subscales (Table 2). This pattern of findings did not change when evaluating partial correlations to control for group differences in peak BrAC. However, results did support significant associations of subjective effects with CASE outcomes (Table 3), the most consistent observation being greater self-administration as a function of lower BAES sedation and higher scores on DEQ liking/wanting scales.
