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Chunk #26 — Results — Associations of self-reported alcohol sensitivity and subjective responses with self-administration

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Associations of OPRM1 A118G and alcohol sensitivity with intravenous alcohol self-administration in young adults.
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Participants classified as low sensitivity on the ASQ stimulation scale (i.e., reporting more drinks to achieve ascending limb effects) achieved significantly higher peak BrAC (M=90.33, SD=22.63) than those classified as high sensitivity (M=73.68, SD=24.74), F (1,38) = 4.84, p = .03). Significant differences were not observed for peak BrAC or drink requests as a function of ASQ sedation score. AUC did not differ a function of ASQ stimulation or sedation scores (ps > .05). However, those classified as low sensitivity on ASQ stimulation were more likely to exceed 80mg% (77.8% of participants) compared to high sensitivity participants (40.9%), (χ2[1]= 5.51, p = .02). This finding was not observed for the ASQ sedation scale, with heavy episodes being as common in of low sensitivity (56.5%) and high sensitivity (58.8%) participants (χ2[1]= 0.02, ns).