Chunk #19 — MATERIALS and METHODS — Bioinformatics Analyses

Source

KAT2B polymorphism identified for drug abuse in African Americans with regulatory links to drug abuse pathways in human prefrontal cortex.

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Linkage disequilibrium patterns were discerned using LocusZoom (Pruim et al., 2010) with populations of EUR or AFR ancestry. Novel genes implicated in our GWAS analyses were input into GeneMANIA (Zuberi et al., 2013) to generate hypotheses about function by building networks of genes that share pathways, physical interactions, protein domains, and other features.