In this study, we examined our ability to develop a profile of FASD based on neuropsychological variables. In comparison to our previous study (Mattson et al., 2010b), we used a larger dataset (N = 468) collected from five sites in the U.S. and one site in South Africa and included a clinical contrast group of non-exposed children with ADHD. Our aim was to improve our classification of AE children with and without FAS and to test the specificity of our profile. The addition of this clinical contrast group is critical in that it lends additional clinical significance and utility to our results. As in our previous study, our ability to accurately classify subjects with AE was statistically significant. Our classification accuracy for FAS subjects was somewhat reduced from our previous study, while classification accuracy for the AE subjects without FAS was slightly improved. In the first study, we accurately classified 88% of FAS and 68% of AE/Non-FAS subjects. In the current study, these classification rates were 77% and 70%, respectively. There were several significant differences between the two studies that