Chunk #25 — Results — Biometric Model Fitting: Age of Substance Use Initiation — Multivariate models

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Age at first use and later substance use disorder: Shared genetic and environmental pathways for nicotine, alcohol, and cannabis.

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and specific levels, dropping them simultaneously resulted in a significant decrement in fit. For the women, the best-fitting model (IV) contained common sources of shared environmental and unique environmental influence, as well as specific genetic and unique environmental factors. Table S6 in supplemental materials indicates the proportion of variation in the age of substance use initiation due to common and substance-specific sources of genetic and environmental variance within the full common pathway model.