Chunk #14 — METHODS — QUANTITATIVE TRAIT

Source

A comparison of approaches to account for uncertainty in analysis of imputed genotypes.

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To simulate trait data yi∗ for individual i (1,…,n) at a single SNP, we used the following model: (2)yi∗=μ∗+(−a)I{gi=0}+(d)I{gi=1}+(a)I{gi=2}+εi, where gi is the true genotype for individual i, a and d are chosen according to (1), the indicator variable I{A} is one if A is true and zero otherwise, and εi ~N(0, 1).