OxoSQ infused into the LDTg suppressed lever pressing for cocaine dose-dependently, mainly during the first 2 hours of the sessions. In some sessions after OxoSQ 10nmol (N = 6 rats) and OxoSQ 1nmol (N = 4 rats) treatment, rats reached BPs of 0 (N= 1 after 1nmol and 4 after 10nmol), 1 (N=2 after 1nmol and 1 after 10nmol) and 2 (N=1 after 1nmol and 1 after 10nmol) within 70 min. These sessions were restarted for an additional 180 min to determine whether OxoSQ had effects early after infusion that abated over time, resulting in increased lever pressing later in the session. The number of cocaine infusions, starting at the 90 min time bin on, cumulatively included infusions from the initial sessions. Repeated measures ANOVAs performed for each time bin, with dose as the repeated measure, showed significant main effects of experimental treatment (Fig 2A) in time bins 60 to 120 min [F60min (2, 22) = 4.8, p < 0.02; F90min (2, 22) = 4.7, p < 0.02; F120min (2, 22) = 5.7, p < 0.01]. Though not statistically significant,
