of experimental treatment (Fig 2A) in time bins 60 to 120 min [F60min (2, 22) = 4.8, p < 0.02; F90min (2, 22) = 4.7, p < 0.02; F120min (2, 22) = 5.7, p < 0.01]. Though not statistically significant, a statistical trend [F (2,18) = 3.5, p = 0.061] was observed for the first 30-min bin as well. Pairwise mean comparisons for time bins 60 to 120 min with Bonferroni correction showed that only OxoSQ 10 nmol caused a significant reduction in mean cocaine infusions compared to aCSF (p60min = 0.022, p90min = 0.042, p120min = 0.027) (Fig 2A). When all six time bins were included in the analysis, the time by treatment interaction was not significant [F (5, 41) = 0.9, p = 0.49]. However, the number of animals remaining in the final hour was only nine, resulting in markedly reduced power for the analysis across time. In addition, a majority of animals (9 out of 12; Fig 2A) reached a similar number of infusions by the third hour, regardless of treatment. Repeated measures ANOVAs on BPs, which included only the initial BPs for all animals (including those for which sessions were restarted) showed a significant main effect
