The neuroticism sum-score was associated with genes expressed in 6 brain tissue types, all of which were also associated to at least one of the individual items. In addition, 2 brain tissue types, amygdala and caudate basal ganglia, were only identified in item-level gene-set analyses. Overall, while some gene-sets were implicated by multiple sources (Fig. 2), the gene-set analyses also confirmed the presence of genetic heterogeneity between the 12 neuroticism items and the sum-score.
