In general, the stepwise inclusion of haplotype information progressively strengthened the associations between ND and AD with the models specifying haplotypes 2, 3 and 4 being significantly associated with all three forms of substance uses disorders (SUD). Of note, the associations tended to be stronger for the female subjects than for the male subjects. Interestingly, a significant association with ASPD and MDD using the regression model specifying only haplotype 3 was noted. However, no other significant associations with either MDD or ASPD were noted under any other model.
