Using this haplotype information, using an additive risk model, we conducted ordinal logistic regression analyses with respect to five major phenotypes found in the IAS. We specified haplotypes 2, 3, 4 and 6 as “risk haplotypes” because these haplotypes (see Figure 2), in at least part, contain some of the risk variants from the SNPs from Table II. For example, haplotypes 2 and 3 each have the “risk alleles” from all of the 32 SNPs significantly associated with AD from Table II, while haplotype 4 has 25 of the “risk alleles”, and haplotype 6 has 12 of the “risk alleles” from Table II. Because the rates of each of these disorders differ by sex, we conducted each of these analyses using all subjects combined, then separately by sex. Table IV delineates the classification scheme, the number of “risk” haplotypes included under each model.
